Training in Schizophrenia and Psychotic Disorders: From Animal Models to Patients

项目摘要 本申请书旨在续期第5T32MH018870号补助金，“精神分裂症及精神障碍训练： 从动物模型到患者“，该项目自1988年以来一直得到资助。目标是培养博士后(医学博士、 博士和博士)作为独立研究人员的职业生涯。我们的目标的实现程度是以 有多少研究员继续处于研究密集的轨道上，无论是得到K奖还是其他来源的支持 资金的问题。在一个密集的三年计划中，研究员学习确定关键的研究问题，制定 假设，并设计和执行测试这些假设的实验。研究员所需的其他技能 要成为一名独立的研究人员，包括了解成功研究的管理 企业、有效协作和写作资助。关于负责任的行为的全面培训 研究在团契早期就开始了。一名研究员必须保持最高标准的科学诚信和 了解与人类和动物研究相关的伦理问题。 培训方案的成功既体现在受训者的成就上，也体现在 研究人员的多样性。在过去的15年里，42名研究员被选中参加培训计划；33% 女性，10%的少数民族，33%的医学博士，29%的医学博士和38%的博士，29%的人来自哥伦比亚精神病学 住院医师计划，71%来自外部。在过去的10年里，由于我们加强了少数族裔的招聘 利维奖学金的努力和对我们招募学员能力的影响，我们招募了15%的少数族裔 38%的非白人和/或非欧洲后裔，以及从哥伦比亚居住地招募的那部分人 攀升至42%。此外，在过去的10年里，我们的医学博士/博士的比例增加到了31%。这个 奖学金毕业率在过去15年中为97%(31/32)；没有毕业的研究员离开了 经过一年的研究，将研究成果转化为心理健康政策和实践，以追求 纽约心理健康办公室的临床管理职位，实施他的研究，我们还 考虑一下成功吧。在这些毕业生中，94%的人留在了研究领域，70%的人在研究密集型领域 与研究相关的职位占比为24%。在上一届毕业的31名研究员中 15年来，69%的人获得了K奖。在毕业5年以上的学生中，62%的人获得了 R-Level资金来自NIH，72%接受了主要的联邦资金(NIH或国防部)，以及 95%的学生获得了一项或多项研究资助(包括基金资助)。目前，有 8名研究员：2名三年级，2名二年级，4名一年级；一名研究员已被录取 2019年7月开始。

Project Summary This application is for renewal of grant 5T32MH018870, “Training in Schizophrenia and Psychotic Disorders: From Animal Models to Patients”, that has been funded since 1988. The goal is to train postdoctoral (MD, MD/PhD, and PhD) fellows for careers as independent researchers. Achievement of our goal is measured by how many fellows continue in a research-intensive trajectory whether supported by a K award or other sources of funding. During an intensive three-year program, fellows learn to identify key research questions, formulate hypotheses, and design and execute experiments that test those hypotheses. Other skills required for a fellow to become an independent researcher include understanding the administration of a successful research enterprise, effective collaboration and writing grants. Comprehensive training in the Responsible Conduct of Research begins early in the fellowship. A fellow must maintain the highest standards of scientific integrity and understand the ethical issues relevant to human and animal research. The success of the training program is reflected in both the accomplishments of the trainees and in the diversity of the fellows. In the past 15 years, 42 fellows have been selected to enter the training program; 33% female, 10% minorities, 33% MDs, 29% MD/PhDs and 38% PhDs, with 29% from the Columbia Psychiatric Residency program and 71% from outside. Over the past 10 years, due to our enhanced minority recruitment efforts and the impact of the Levy Fellowship on our ability to recruit trainees, we have recruited 15% minorities and 38% of non-white and/or non-European descent, and the fraction recruited from the Columbia residency has climbed to 42%. Furthermore, our fraction of MD/PhDs has increased to 31% over the past 10 years. The graduation rate of the fellowship is 97% over the last 15 years (31/32); the one fellow who did not graduate left after 1 year of research on the translation of research findings into mental health policy and practice to pursue a clinical administration position in the New York Office of Mental Health implementing his research, which we also consider a success. Of these graduates, 94% have remained in research, with 70% in research-intensive positions and 24% in research-related positions. Of the 31 fellows who have graduated the program in the last 15 years, 69% have been awarded K awards. Of those who graduated more than 5 years ago, 62% have received R-level funding from the NIH, 72% have received major federal funding (NIH or Department of Defense), and 95% have received one or more research grants of some kind (including foundation support). Currently, there are 8 fellows: 2 third-year, 2 second-year, and 4 in the first year of training; one fellow has been accepted to begin in July 2019.