Training in Schizophrenia and Psychotic Disorders: From Animal Models to Patients

 产品说明：这是一份申请书，要求更新资助T32-MH018870，“精神分裂症和精神病障碍的培训：从动物模型到患者”（自1988年以来持续资助）。在过去的10年里，28名研究员被选中进入培训计划：39%的医学博士，21%的医学博士/博士，11%的临床心理学家和29%的基础科学博士。43%的研究员是从哥伦比亚精神病学住院医师项目招募的，43%是女性，7%是代表性不足的少数民族或残疾人实习生。在过去10年中，该研究金的毕业率为95%（19/20）。目前，有6名研究员：2名三年级研究员、3名二年级研究员和1名一年级研究员; 2名新研究员已被接受，将于2014年底前开始工作-均为精神科医生，一名为医学博士/博士。在过去10年中毕业的19名研究员中，有12名（63%）获得了K奖，目前正在准备或正在审查现有研究员或最近的毕业生提交的4 K奖。3名毕业生（16%）已经获得R01，另外2名被列为R01的关键人员（包括1名作为R01的主要人员）。2名毕业生获得了R21，其他几名毕业生的申请正在等待中。总的来说，所有19名毕业生都获得了大量的独立资助，包括R01，K奖，R21奖，NARSAD奖，以及来自纽约干细胞科学和其他资助机构的资助。在19名毕业生中，有14名（74%）从事全职学术研究工作：其他人则从事工业研究或临床管理。 在2009年11月16日审查的T32的最后一次提交中，委员会得出结论："总体而言，这一杰出申请的优势明显超过了小问题[新项目负责人]，审查人员认为该培训项目在精神分裂症研究领域成功地培训了翻译和跨学科研究人员。"最后提交的材料描述了一个培训计划，通过加强教学计划，并通过在这一领域战略性地增加教师导师，加强了翻译研究的机会。自续约以来，我们已采取实质性措施，进一步改善我们的培训计划。重要的是，我们还制定了一个计划，以招募精神病住院医师在哥伦比亚医学博士/博士，其重点是神经科学研究。该计划提供了大量的研究时间和资金在居住期间。该计划一直是一个非常有效的招聘工具，为居民，也提供了一个非常强大的管道MD/博士医生科学家的奖学金。另一个将加强T32和住院医师招聘的发展是哥伦比亚将于2016年开放的新神经科学大楼。这座大楼将容纳大约65个神经科学研究实验室，其中20个将是新员工。因此，研究员毕业后的培训和工作机会在不久的将来将大大增加。教学计划取得了实质性进展，计划主任现在有7年的工作经验。

 DESCRIPTION: This is an application for renewal of grant T32-MH018870, "Training in Schizophrenia and Psychotic Disorders: From Animal Models to Patients" (continuously funded since 1988). In the past 10 years, 28 fellows have been selected to enter the training program: 39% MDs, 21% MD/PhDs, 11% Clinical Psychologists, and 29% Basic Science PhDs. 43% of fellows have been recruited from the Columbia Psychiatry Residency program, 43% have been women, and 7% have been either an Underrepresented Minority or Disadvantaged trainee. The graduation rate of the fellowship has been 95% over the last 10 years (19/20). Currently, there are 6 fellows: 2 third-year, 3 second-year and 1 in the first year of training; 2 new fellows have been accepted to begin before the end of 2014-both psychiatrists and one an MD/PhD. Of the 19 fellows who have graduated the program in the past 10 years, 12 (63%) have been awarded K awards and 4 K award submissions are currently in preparation or under review from current fellows or very recent graduates. 3 graduates (16%) have already received R01s with another 2 listed as key personnel on R01s (including 1 role as a subcontract PI). 2 graduates have received R21s, and several others have applications pending. In total, all 19 graduates have received substantial independent funding including R01s, K awards, R21 awards, NARSAD awards, and grants from New York Stem Cell Science and other funding agencies. Of the 19 graduates, 14 (74%) are in full-time academic research positions: others are involved in research in industry or in clinical administration. In the last submission of this T32, reviewed o 11/16/2009, the committee concluded: "Overall, the strengths of this outstanding application significantly outweighed the minor concern [new Program Directors], and the reviewers felt the training program was succeeding in training translational and interdisciplinary researchers within the field of schizophrenia research." The last submission described a training plan that strengthened the opportunities in translational research by enhancement of the didactic teaching program, and through the strategic addition of faculty mentors in this area. Since its renewal, we have taken substantive steps to further improve our training program. Importantly, we have also developed a program to recruit to the Psychiatric Residency at Columbia MD/PhDs whose focus is neuroscience research. This program provides substantial research time and funding during the residency. This program has been a very effective recruitment tool for the residency and also provides a very strong pipeline of MD/PhD physician-scientists for the fellowship. Another development that will enhance recruitment for this T32 and the residency is Columbia's new neuroscience building to be opened in 2016. This building will house approximately 65 neuroscience research labs, 20 of which will be new hires. Thus the training and job opportunities after graduation for fellows will be significantly increased in the near future. There have been substantial advances in the didactic program, and the Program Directors now have 7 years of experience in their positions.