MOLECULAR MECHANISM OF CANCER

癌症的分子机制

• 批准号: 8486598
• 负责人: MICHELLE M LE BEAU
• 金额: $ 2.33万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8486598
• 关键词: Adult; Animal Model; Apoptotic; Area; Autophagocytosis; Basic Science; Bioinformatics; Biological; Biological Markers; Biology; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancerous; Cell Differentiation process; Cell Proliferation; Cell Survival; Cell-Cell Adhesion; Cells; Cessation of life; Chemistry; Chicago; Clinical; Collaborations; Comprehensive Cancer Center; Core Facility; Development; Developmental Biology; Distant; Ecology; Epigenetic Process; Evolution; Faculty; Funding; Gene Expression; Gene Expression Regulation; Gene Proteins; Genetic; Genome; Genomics; Goals; Growth Factor; Growth Factor Receptors; In Vitro; Instruction; Journals; Laboratories; Leadership; Malignant Neoplasms; Mediating; Mentors; Metabolism; Methodology; Modeling; Molecular; Molecular Biology; Nature; Neoplasm Metastasis; Nuclear Receptors; Organ; Outcome; Pathway interactions; Patients; Peer Review; Pilot Projects; Play; Post-Translational Protein Processing; Property; Proteome; Publications; Publishing; Radiation therapy; Receptor Signaling; Regulation; Research; Research Infrastructure; Research Personnel; Resistance; Risk; Science; Scientist; Series; Signal Pathway; Signal Transduction; Site; Stress Response Signaling; Structure; System; Systems Biology; Therapeutic; Tissues; Training Programs; Transcriptional Regulation; Translational Research; Translations; Tumor Biology; Tumor Subtype; Universities; Update; Ursidae Family; Work; anticancer research; cancer cell; cancer therapy; cell growth; cell transformation; cell type; chemotherapy; clinical care; computer science; drug discovery; improved; in vivo Model; innovation; interest; meetings; member; neoplastic cell; novel; programs; technology/technique development; transcription factor; tumor; tumor microenvironment; tumor progression

The Molecular Mechanisms of Cancer Program (MMC) brings together basic and translational investigators dedicated to the study of cancer through research in cell signaling, molecular biology, systems biology, developmental biology, and chemistry/drug discovery. The Program has refined its membership from 46 to 36 to reflect increased cancer focus. Peer-reviewed funding of $14,681,074 (annual DC), with $5,863,767 from the NCI, has remained steady despite fewer members. Program members are highly-productive, with 416 peer-reviewed publications, including 12% that were intraprogrammatic, and 26% interprogrammatic publications during the past funding period. Moreover, 38% of these articles were published in high impact (impact factor >10) journals. Although our members' interests are varied, several common themes have emerged. Overall, the basic research objectives of our scientists can be divided into the following five themes: 1) to elucidate the molecular mechanisms of tissue-specific and cell type-specific gene expression; 2) to elucidate the cellular mechanisms underlying cell growth/division and cell survival/death; 3) to understand the multi-faceted mechanisms leading to cancer metastases; 4) to use large-scale, high-throughput systems biology approaches and genetic evolutionary approaches to understand cancer biology; and 5) to discover novel developmental pathways relevant to cancer cell signaling. MMC members' fundamental scientific discoveries in these areas are further encouraged by Program 1 leadership to fuel hypothesis-driven clinical and translational cancer research and to contribute to the broader UCCCC initiative of personalized cancer treatment. Significantly, our membership has developed numerous collaborations with clinician-scientists both within the MMC Program and interprogramatically, reflecting the cross-disciplinary and translational nature of our research program. The MMC Program provides support and the structure for these collaborations among the Program's basic cancer biologists, while primarily representing the broad cancer relevant basic science strengths of the University of Chicago (UChicago). Through pilot funding, quarterly membership meetings, a seminar series, an annual retreat, and a strong basic science training program in cancer biology, the MMC Program is poised to continue its successful in-depth and basic research focus on cancer biology, while nurturing collaborative science that will enhance the clinical care of patients at risk or with cancer.

癌症的分子机制计划（MMC）汇集了基础和翻译 研究人员致力于通过研究细胞信号传导，分子生物学，系统生物学，发育生物学和化学/药物发现来研究癌症。该计划已将其成员从46个调整到36个，以反映对癌症关注的增加。同行审议的资金为14，681，074美元（年度DC），其中5，863，767美元来自NCI，尽管成员减少，但仍然保持稳定。项目成员的工作效率很高，有416篇同行评审的出版物，其中12%是项目内出版物，26%是项目间出版物。此外，38%的文章发表在高影响力（影响因子>10）期刊上。 虽然我们成员的兴趣各不相同，但出现了几个共同的主题。总体而言，我们的科学家的基本研究目标可以分为以下五个主题：1）阐明组织特异性和细胞类型特异性基因表达的分子机制; 2）阐明细胞生长/分裂和细胞存活/死亡的细胞机制; 3）了解导致癌症转移的多方面机制; 4）了解癌症转移的分子机制。4）使用大规模，高通量系统生物学方法和遗传进化方法来理解癌症生物学; 5）发现与癌细胞信号传导相关的新的发育途径。MMC成员在这些领域的基础科学发现得到了计划1领导的进一步鼓励，以推动假设驱动的临床和转化癌症研究，并为更广泛的UCCCC个性化癌症倡议做出贡献 治疗值得注意的是，我们的成员已经与临床科学家在MMC计划内和跨学科地开展了许多合作，反映了我们研究计划的跨学科和转化性质。MMC计划为该计划的基础癌症生物学家之间的这些合作提供支持和结构，同时主要代表芝加哥大学（U芝加哥）广泛的癌症相关基础科学优势。通过试点资金，季度会员会议，研讨会系列，年度务虚会和癌症生物学的强大基础科学培训计划，MMC计划准备继续其成功的深入和基础研究重点癌症生物学，同时培养合作科学，这将提高风险或风险患者的临床护理。 得了癌症