MOLECULAR MECHANISM OF CANCER

癌症分子机制计划(MMC)结合了基本的和翻译的 研究人员致力于通过细胞信号、分子生物学、系统生物学、发育生物学和化学/药物发现等方面的研究来研究癌症。该计划已将其成员从46人细化到36人，以反映癌症焦点的增加。同行审查的资金为14,681,074美元(每年DC)，其中5,863,767美元来自NCI，尽管成员较少，但仍保持稳定。方案成员的工作效率很高，在过去的供资期间，有416份经同行审查的出版物，其中12%是方案内出版物，26%是方案间出版物。此外，38%的文章发表在高影响力(影响因子)期刊上。 尽管我们成员的兴趣各不相同，但出现了几个共同的主题。总体而言，我们的科学家的基本研究目标可以分为以下五个主题：1)阐明组织特异性和细胞类型特异性基因表达的分子机制；2)阐明细胞生长/分裂和细胞生存/死亡的细胞机制；3)了解导致癌症转移的多方面机制；4)使用大规模、高通量的系统生物学方法和遗传进化方法来了解癌症生物学；以及5)发现与癌细胞信号相关的新的发展途径。MMC成员在这些领域的基础科学发现受到计划1领导力的进一步鼓励，以支持假说驱动的临床和转化性癌症研究，并为更广泛的UCCCC个性化癌症倡议做出贡献 治疗。值得注意的是，我们的成员在MMC计划内和计划间都与临床医生和科学家发展了大量的合作，反映了我们研究计划的跨学科和翻译性质。MMC计划为该计划的基础癌症生物学家之间的这些合作提供支持和结构，同时主要代表芝加哥大学(UChicago)与癌症相关的广泛基础科学优势。通过试点资助、季度会员会议、系列研讨会、年度务虚会和强大的癌症生物学基础科学培训计划，MMC计划准备继续其在癌症生物学方面成功的深入和基础研究重点，同时培育协作性科学，以加强高危患者的临床护理。 得了癌症。

The Molecular Mechanisms of Cancer Program (MMC) brings together basic and translational investigators dedicated to the study of cancer through research in cell signaling, molecular biology, systems biology, developmental biology, and chemistry/drug discovery. The Program has refined its membership from 46 to 36 to reflect increased cancer focus. Peer-reviewed funding of $14,681,074 (annual DC), with $5,863,767 from the NCI, has remained steady despite fewer members. Program members are highly-productive, with 416 peer-reviewed publications, including 12% that were intraprogrammatic, and 26% interprogrammatic publications during the past funding period. Moreover, 38% of these articles were published in high impact (impact factor >10) journals. Although our members' interests are varied, several common themes have emerged. Overall, the basic research objectives of our scientists can be divided into the following five themes: 1) to elucidate the molecular mechanisms of tissue-specific and cell type-specific gene expression; 2) to elucidate the cellular mechanisms underlying cell growth/division and cell survival/death; 3) to understand the multi-faceted mechanisms leading to cancer metastases; 4) to use large-scale, high-throughput systems biology approaches and genetic evolutionary approaches to understand cancer biology; and 5) to discover novel developmental pathways relevant to cancer cell signaling. MMC members' fundamental scientific discoveries in these areas are further encouraged by Program 1 leadership to fuel hypothesis-driven clinical and translational cancer research and to contribute to the broader UCCCC initiative of personalized cancer treatment. Significantly, our membership has developed numerous collaborations with clinician-scientists both within the MMC Program and interprogramatically, reflecting the cross-disciplinary and translational nature of our research program. The MMC Program provides support and the structure for these collaborations among the Program's basic cancer biologists, while primarily representing the broad cancer relevant basic science strengths of the University of Chicago (UChicago). Through pilot funding, quarterly membership meetings, a seminar series, an annual retreat, and a strong basic science training program in cancer biology, the MMC Program is poised to continue its successful in-depth and basic research focus on cancer biology, while nurturing collaborative science that will enhance the clinical care of patients at risk or with cancer.