CANCER PREVENTION AND CONTROL

癌症预防和控制

• 批准号: 8486618
• 负责人: MICHELLE M LE BEAU
• 金额: $ 2.29万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8486618
• 关键词: Alcohol consumption; Alcohols; Area; Behavioral; Biological; Cancer Center Support Grant; Cancer Control; Cancer Survivorship; Chicago; Clinical; Clinical Investigator; Collaborations; Communities; Development; Diagnosis; Dimensions; Direct Costs; Early Diagnosis; Economic Factors; Economics; Environmental Epidemiology; Etiology; Funding; Gender; Genetic; Goals; Growth; Health; Human; Instruction; Interdisciplinary Study; Knowledge; Laboratory Study; Life Style; Malignant Neoplasms; Molecular Epidemiology; Nutritional; Outcome; Peer Review; Population Research; Population Sciences; Prevention; Prevention Research; Prevention program; Preventive; Public Health Practice; Publications; Race; Research; Research Activity; Risk; Science; Social Sciences; Tobacco; Tobacco use; Translating; Universities; addiction; base; biobehavior; cancer diagnosis; cancer prevention; cancer risk; cost effectiveness; economic outcome; genetic epidemiology; global health; health disparity; member; novel; nutritional genomics; outcome forecast; outreach; preclinical study; programs; psychologic; psychosocial; screening; survivorship; treatment strategy

The Cancer Prevention and Control (CPC) Program has undergone substantial growth and reorganization. It is an extremely interdisciplinary program involving 40 members from 12 Departments representing basic, translational, prevention and clinical investigators. Members have a total of $1 IM (annual direct costs) in peer-reviewed funding, including $4M from the NCI. During 2008-2011, CPC Program members generated a total of 473 peer-reviewed publications, including 16% intraprogrammatic, and 25% interprogrammatic publications. The overall goal of the Program is to promote novel cancer population science discoveries through interdisciplinary research, and to translate the knowledge into clinical and public health practice. The Program research spectrum is centered on understanding the determinants of major transition steps along the human health continuum, i.e., from the healthy state to the development of cancer, and then to cancer outcomes, as well as studying potential avenues of prevention. Thematically, the research themes are organized under two major themes: Theme 1) cancer risk and prevention; and Theme 2) cancer outcomes. The specific scientific objectives in Theme 1 are to: la) identify novel genomic, nutritional, and environmental determinants and their interactions in cancer risk; lb) identify the biological and behavioral basis for tobacco and alcohol use, and apply this knowledge to develop prevention and cessation-related treatment strategies; and Ic) examine biological and behavioral factors related to screening, early detection and prevention of cancer. The specific scientific objectives in Theme 2 are to: 2a) investigate the bio-behavioral, psychosocial and environmental determinants of cancer-related health outcomes, including survivorship; and 2b) examine cost-effectiveness and economic factors related to cancer diagnosis, treatment, and survivorship. As a cross-cutting theme, the majority of our Program members are focused on health disparities research in both local and global contexts. The CPC Program has well-established strengths in molecular, genetic and environmental epidemiology, biobehavioral and addiction research, as well as laboratory and preclinical studies in prevention sciences. A sub-theme on cancer outcomes, economics and survivorship research adds a new dimension to Program research by taking advantage of University of Chicago renowned strengths in economics and social sciences. Overall, the Program encompasses substantial transdisciplinary interactions and collaborations within and across programs.

癌症预防和控制方案经历了实质性的增长和重组。这是一个非常跨学科的计划，涉及来自12个部门的40名成员，代表基础，翻译，预防和临床研究人员。成员们共有1美元的IM（年度直接费用）同行评审资金，包括来自NCI的400万美元。在2008-2011年期间，CPC方案成员共产生了473份同行评审出版物，其中包括16%的方案内出版物和25%的方案间出版物。 该计划的总体目标是通过跨学科研究促进新的癌症人群科学发现，并将知识转化为临床和公共卫生实践。该计划的研究范围集中在理解人类健康连续体沿着主要过渡步骤的决定因素，即，从健康状态到癌症的发展，再到癌症的结果，以及研究潜在的预防途径。在主题上，研究主题分为两大主题：主题1）癌症风险和预防;主题2）癌症结果。主题1的具体科学目标是：a）确定新的基因组，营养和环境决定因素及其在癌症风险中的相互作用; b）确定烟草和酒精使用的生物学和行为基础，并应用这些知识制定预防和戒烟相关的治疗策略;和Ic）检查与癌症筛查，早期发现和预防相关的生物学和行为因素。主题2的具体科学目标是：2a）调查癌症相关健康结果（包括生存率）的生物行为、心理社会和环境决定因素; 2b）检查与癌症诊断、治疗和生存率相关的成本效益和经济因素。作为一个跨领域的主题，我们的大多数计划成员都专注于在当地和全球范围内的健康差距研究。 CPC计划在分子，遗传和环境流行病学，生物行为和成瘾研究以及预防科学的实验室和临床前研究方面具有良好的优势。关于癌症结果，经济学和生存研究的子主题通过利用芝加哥大学在经济学和社会科学方面的着名优势，为计划研究增加了一个新的维度。总的来说，该计划包括大量的跨学科的互动和合作内和跨程序。