Translating Translation and Scientific Questioning in the Global K-12 Community

描述（由申请人提供）：美国国立卫生研究院最近的举措旨在重新设计临床研究，促进多样化的劳动力，提高健康/科学素养，加速发现从“实验室到床边到社区”的“转化”。“翻译翻译”的关键是将“医学语言”引入K-12社区和公众；并提高人们对生物医学“知识”的短暂性、科学事业的社会方面的认识；以及决策的不确定性，即让学生为不可预测的未来做好准备。随着宽带互联网的广泛使用，美国国家卫生研究院和国家环境保护署的这项建议，来自一个经验丰富的转化科学家团队，致力于为弱势学生提供以结果为导向的教育干预，利用了广泛的项目基础设施，人员和合作伙伴关系。独特的核心是虚拟临床研究中心/问卷调查（VCRC/Q）基于网络的平台，开发了5年，旨在扩展现实生活中的“基于地点的座位计时”K-12学校体验。为了开发VCRC/Q作为一个可定制的双向“学习网格”的潜力，将科学家与全球“学习社区”中的K-12学生/教师联系起来，我们的具体目标（SA）是：1)实施、扩大和网络化临床转化科学奖/临床研究中心、国家环保总局项目、K-12学校和公众之间的交流；2)由训练有素的教师在VCRC/Q上或在教室/实验室面对面地针对高中学生，组装、整合和测试可定制的探究式“翻译翻译”核心课程，以激发、激励和教育年轻人关于生物医学研究的冒险和机会。“翻译翻译”将介绍医学语言，展示NIH的研究和不同的专家/同行的榜样，在范式转变中强调医学“知识”-“已知”（毋庸置疑的答案）和医学“无知”（未回答的问题：我们知道我们不知道，不知道我们不知道，认为我们知道但不知道）-“未知”之间的动态不平衡；3)将平台和课程整合到一个强大的自我更新的职业管道中，有多个切入点，通过连接渐进的夏季和全年的“动手-大脑”研究经验，培养越来越多的多样化的年轻科学家领导干部，这是我们长期以来引入的医学无知暑期研究所（约500名弱势高中校友）。SA3将为入门级学生科学家提供“高辛烷值”途径，在以团队为导向的实验室/临床研究和领导方面受到密切指导，并为家庭和公众提供小剂量的“低辛烷值”和“自助”选择。一个全面的形成性和总结性评估包括一个3阶段模型（设计>测试>改进；实施>测试>改进；传播>测试>改进），重点关注态度、技能和知识的变化以及长期结果/影响，包括能力建设、职业轨迹、可移植性和网络扩展。VCRC/Q的传播中心与多媒体、多机构伙伴关系加强外联和影响。

DESCRIPTION (provided by applicant): Recent NIH initiatives target reengineering clinical research, fueling a diverse workforce, and improving health/ science literacy, to accelerate "translation" of discoveries from "bench to bedside to community." Key to "translating translation" is introducing the "language of medicine" to the K-12 community and public; and raising awareness of the transiency of biomedical "knowledge", social aspects of the scientific enterprise; and uncertainty in decision-making, i.e., preparing students for an unpredictable future. With broadband Internet connectivity widely available, this NIH-SEPA proposal, from an experienced team of translational scientists devoted to outcomes-oriented educational interventions for disadvantaged students, leverages a broad infrastructure of programs, people, and partnerships. The unique centerpiece is the Virtual Clinical Research Center/Questionarium (VCRC/Q) web-based platform, 5 years in development, designed to expand real-life "place-based seat-timed" K-12 school experiences. To exploit VCRC/Q's potential as a customizable bi- directional "learning grid" linking scientists with K-12 students/ teachers in a global "learnig community", our specific aims (SA) are; 1) implement, scale and network the VCRC/Q Platform to facilitate communication among Clinical Translational Science Awards/Clinical Research Centers, SEPA projects, K-12 schools, and the public; 2) assemble, integrate and test a customizable inquiry-based "Translating Translation" core curriculum targeting high school students on VCRC/Q or face-to-face in classrooms/labs by trained teachers to excite, motivate, and educate young minds about the adventure and opportunities in biomedical research. "Translating Translation" will introduce medical language and showcase NIH research and diverse experts/ peer-near peer role models in a paradigm shift emphasizing the dynamic imbalance between medical "knowledge" - the "known" (unquestioned answers) and medical "ignorance" (unanswered questions: what we know we don't know, don't know we don't know, and think we know but don't) - the "unknown"; and 3) incorporate platform and curriculum into a robust self-renewing career pipeline with multiple entry points to nurture a growing cadre of diverse young scientist-leaders by bridging progressive summer and year-round "hands on-brain on" research experiences modeled after our long-standing introductory Summer Institute on Medical Ignorance (~500 disadvantaged high school student alumni). SA3 will feature a "high octane" pathway for entry-level student scientists closely mentored in team-oriented laboratory/ clinical research and leadership and "low octane" and "self-serve" options in smaller doses for home use and the public. A comprehensive formative and summative evaluation includes a 3-phase model (design>test>refine; implement>test>refine; disseminate>test>refine) focusing on changes in attitudes, skills, and knowledge and long-term outcomes/ impact including capacity building, career tracks, transportability, and network expansion. Dissemination centers in VCRC/Q with multimedia, multi-institutional partnerships to enhance outreach, and impact.