Translating Translation and Scientific Questioning in the Global K-12 Community

描述(由申请者提供)：NIH最近的倡议旨在重新设计临床研究，促进多样化的劳动力，并提高健康/科学素养，以加快发现的“转化”，从“长凳到床边到社区”。“翻译”的关键是向K-12社区和公众介绍“医学语言”；提高人们对生物医学“知识”的暂时性、科学事业的社会方面以及决策中的不确定性的认识，即使学生为不可预测的未来做好准备。随着宽带互联网连接的普及，NIH-SEPA的这项提案由经验丰富的翻译科学家团队提出，致力于为弱势学生提供注重结果的教育干预，利用了广泛的项目、人员和合作伙伴基础设施。独特的核心是虚拟临床研究中心/问答中心(VCRC/Q)基于网络的平台，经过5年的开发，旨在扩大现实生活中的“基于地点的座位计时”K-12学校体验。为了开发VCRC/Q作为一个可定制的双向“学习网格”的潜力，我们的具体目标(SA)是：1)实施、扩大和联网VCRC/Q平台，以促进临床翻译科学奖/临床研究中心、国家环保总局项目、K-12学校和公众之间的沟通；2)通过VCRC/Q或由训练有素的教师在课堂/实验室中面对面地培训高中生，组装、整合和测试可定制的基于探究的“翻译”核心课程，以激发、激励和教育年轻人对生物医学研究的冒险和机会的认识。《翻译》将介绍医学语言，展示NIH的研究和不同的专家/近距离同行的榜样，这是一种范式转变，强调了医学“知识”--“已知”(无疑问的答案)和医学“无知”(未回答的问题：我们知道我们不知道的，不知道我们不知道的，认为我们知道但不知道的)--之间的动态不平衡；3)将平台和课程整合到一个强大的自我更新的职业管道中，并有多个切入点，通过将不断进步的夏季和全年的“面对面”研究经验联系起来，培养日益增长的多样化的年轻科学家和领导者队伍。我们的夏季医学无知介绍性研究所(约500名弱势高中学生校友)是我们的典范。SA3将为入门级学生科学家提供“高辛烷值”途径，并在以团队为导向的实验室/临床研究和领导能力方面得到密切指导，并为家庭和公众提供较小剂量的“低辛烷值”和“自助式”选择。全面的形成性和总结性评价包括一个三阶段模式(设计；测试；改进；实施；测试；改进；传播；测试；改进)，重点关注态度、技能和知识的变化以及长期结果/影响，包括能力建设、职业轨迹、可运输性和网络扩展。在VCRC/Q的传播中心利用多媒体、多机构伙伴关系，以加强外联和影响。

DESCRIPTION (provided by applicant): Recent NIH initiatives target reengineering clinical research, fueling a diverse workforce, and improving health/ science literacy, to accelerate "translation" of discoveries from "bench to bedside to community." Key to "translating translation" is introducing the "language of medicine" to the K-12 community and public; and raising awareness of the transiency of biomedical "knowledge", social aspects of the scientific enterprise; and uncertainty in decision-making, i.e., preparing students for an unpredictable future. With broadband Internet connectivity widely available, this NIH-SEPA proposal, from an experienced team of translational scientists devoted to outcomes-oriented educational interventions for disadvantaged students, leverages a broad infrastructure of programs, people, and partnerships. The unique centerpiece is the Virtual Clinical Research Center/Questionarium (VCRC/Q) web-based platform, 5 years in development, designed to expand real-life "place-based seat-timed" K-12 school experiences. To exploit VCRC/Q's potential as a customizable bi- directional "learning grid" linking scientists with K-12 students/ teachers in a global "learnig community", our specific aims (SA) are; 1) implement, scale and network the VCRC/Q Platform to facilitate communication among Clinical Translational Science Awards/Clinical Research Centers, SEPA projects, K-12 schools, and the public; 2) assemble, integrate and test a customizable inquiry-based "Translating Translation" core curriculum targeting high school students on VCRC/Q or face-to-face in classrooms/labs by trained teachers to excite, motivate, and educate young minds about the adventure and opportunities in biomedical research. "Translating Translation" will introduce medical language and showcase NIH research and diverse experts/ peer-near peer role models in a paradigm shift emphasizing the dynamic imbalance between medical "knowledge" - the "known" (unquestioned answers) and medical "ignorance" (unanswered questions: what we know we don't know, don't know we don't know, and think we know but don't) - the "unknown"; and 3) incorporate platform and curriculum into a robust self-renewing career pipeline with multiple entry points to nurture a growing cadre of diverse young scientist-leaders by bridging progressive summer and year-round "hands on-brain on" research experiences modeled after our long-standing introductory Summer Institute on Medical Ignorance (~500 disadvantaged high school student alumni). SA3 will feature a "high octane" pathway for entry-level student scientists closely mentored in team-oriented laboratory/ clinical research and leadership and "low octane" and "self-serve" options in smaller doses for home use and the public. A comprehensive formative and summative evaluation includes a 3-phase model (design>test>refine; implement>test>refine; disseminate>test>refine) focusing on changes in attitudes, skills, and knowledge and long-term outcomes/ impact including capacity building, career tracks, transportability, and network expansion. Dissemination centers in VCRC/Q with multimedia, multi-institutional partnerships to enhance outreach, and impact.