Summers in Childrens Research for Diverse High School Students

描述（由申请人提供）：亚利桑那大学健康科学中心、斯蒂尔儿童研究中心和钻石儿童医学中心的“夏季儿童研究”（SCR）每年将为来自亚利桑那州的8名不同的初中/高中学生和4名继续就读的本科生提供为期8-12周的令人兴奋的暑期教育体验，“动手，动脑”基础和临床研究，广泛针对儿童和发育障碍、孕产妇健康和健康差异。多学科项目领导团队包括一位国际知名的儿科医生，专门研究儿童胃肠道疾病（分子机制和临床管理），一位专注于社区/公共卫生/健康差异的妇产科医生，以及一位儿童和发育性淋巴疾病、多样性管道研究培训和探究课程创新方面的专家。他们将共同与影响儿童和孕产妇健康的充满活力的临床和基础研究项目互动。基于医学院长期以来非常成功的联邦资助的多学科弱势高中生研究项目，吸引了来自亚利桑那州各地的大量合格申请者，以及当地支持的儿科高中学生暑期项目，该项目将逐步开发一个独特的SCR课程，包括在线部分和扩展的研究经验，包括NICHD的使命。研究课题和全日制暑期研究经验将包括炎症性肠病和婴儿腹泻疾病中钙/磷酸盐吸收的分子机制，尼曼-皮克C病的基因组学和蛋白质组学，儿科头部创伤和药物滥用的流行病学，以及孕产妇保健和性传播疾病的实地工作。SCR将包括经验丰富、热情的教师和同行导师，不仅在儿科，而且广泛代表影响儿童和生殖的基础和临床研究，并跨越NICHD的研究方向。专门的SCR暑期课程将被纳入面向高中生的创新的面对面和基于在线探究的医学无知暑期研究所（突出未回答的问题和未提出的答案，并强化核心内容）（与pi的医学生研究员提供的课程平行），并具有高度互动的元素和pi独特的虚拟临床研究中心/问卷调查。VCRC/Q是一个基于网络的网格软件平台，旨在将NIH-CTSAs和gcrc与K-12社区连接起来，使用青少年和更年幼的儿童熟悉的先进多媒体技术。pi将使用同伴和近同伴指导策略和生存/繁荣技能课程来培养在职业道路上的协作团队中工作的富有成果、好奇和道德的科学家的态度、技能和行为。将根据正在进行的进程和程序进行广泛的短期/长期形成性和总结性参与者和项目评价，并在全国传播成功的模式和产品，以便在其他情况下复制。

DESCRIPTION (provided by applicant): "Summers in Children's Research" (SCR) at The University of Arizona Health Sciences Center, Steele Children's Research Center, and Diamond Children's Medical Center will offer annually 8 diverse junior/senior high school students and 4 continuing undergraduates from Arizona an exciting educational 8-12 week summer experience in "hands on, brain on" basic and clinical research broadly targeting childhood and developmental disorders and maternal health and health disparities. The multidisciplinary project leadership team includes an internationally renowned pediatrician specialized in children's gastrointestinal disorders (molecular mechanisms and clinical management) joined by an obstetrician-gynecologist focused on community/public health/health disparities, along with an expert in childhood and developmental lymphatic disorders, diversity pipeline research training, and inquiry curriculum innovation. They will together interact with vibrant clinical and basic research programs impacting children's and maternal health. Based on the College of Medicine's highly successful longstanding federally funded multidisciplinary disadvantaged high school student research program drawing large numbers of qualified applicants from around Arizona and also a locally supported Department of Pediatrics high school student summer program, this project will stepwise develop a distinctive SCR curriculum including online components and expanded research experiences encompassing the NICHD mission. Research topics and full-time summer research experiences will range from molecular mechanisms of calcium/phosphate absorption in inflammatory bowel disease and infant diarrheal disorders to genomics and proteomics of Niemann-Pick C disease, epidemiology of pediatric head trauma and substance abuse, and field work in maternal health and sexually transmitted diseases. SCR will involve experienced, enthusiastic faculty and near-peer mentors not only in Pediatrics but broadly representing basic and clinical research impacting children and reproduction and spanning NICHD research directions. The specialized SCR summer curriculum will be incorporated into an innovative face-to-face and online inquiry-based Summer Institute on Medical Ignorance (highlighting Unanswered Questions and Unquestioned Answers and reinforcing core content) for high school students (paralleling the PIs' medical student researcher offering) and features highly interactive elements and the PIs' unique Virtual Clinical Research Center/Questionarium. VCRC/Q is a web-based gridware platform designed to link NIH-CTSAs and GCRCs to the K-12 community, using advanced multimedia technology familiar to teenagers and younger children. The PIs will use peer and near-peer mentoring strategies and surviving/thriving skill sessions to develop attitudes, skills, and behaviors of fruitful, inquiring, and ethical scientists working in collaborative teams along career pathways. Extensive short-term/long-term formative and summative participant and project evaluation, based on ongoing processes and procedures, will be carried out, and successful models and products disseminated nationally for replication in other settings.