Summers in Childrens Research for Diverse High School Students

描述（申请人提供）：亚利桑那大学健康科学中心、斯蒂尔儿童研究中心和钻石儿童医疗中心的“儿童研究夏季”（SCR）将每年为来自亚利桑那州的8名不同的初/高中学生和4名继续就读的本科生提供一个令人兴奋的8-12周的暑期教育体验，脑”的基础和临床研究，广泛针对儿童和发育障碍以及孕产妇健康和健康差距。多学科项目领导团队包括一位专门研究儿童胃肠疾病（分子机制和临床管理）的国际知名儿科医生，一位专注于社区/公共卫生/健康差异的妇产科医生，沿着一位儿童和发育淋巴疾病专家，多样性管道研究培训和探究课程创新。他们将与影响儿童和孕产妇健康的充满活力的临床和基础研究项目互动。基于医学院非常成功的长期联邦资助的多学科弱势高中生研究计划，吸引了大量来自亚利桑那州各地的合格申请人，以及当地支持的儿科系高中生暑期计划，该项目将逐步开发一个独特的SCR课程，包括在线组件和扩展的研究经验，包括NICHD使命。研究主题和全职夏季研究经验将从炎症性肠病和婴儿腹泻疾病中钙/磷酸盐吸收的分子机制到尼曼-皮克C病的基因组学和蛋白质组学，儿科头部创伤和药物滥用的流行病学，以及孕产妇健康和性传播疾病的实地工作。SCR将涉及经验丰富，热情的教师和近同行导师不仅在儿科，但广泛代表基础和临床研究影响儿童和生殖，并跨越NICHD研究方向。专门的SCR暑期课程将被纳入一个创新的面对面和在线调查为基础的医学无知暑期研究所（突出未回答的问题和无疑问的答案，并加强核心内容）为高中生（平行PI的医学生研究员提供），并具有高度互动的元素和PI独特的虚拟临床研究中心/虚拟现实。VCRC/Q是一个基于网络的网格平台，旨在将NIH-CTSA和GCRC与K-12社区联系起来，使用青少年和幼儿熟悉的先进多媒体技术。PI将使用同行和近同行的指导策略和生存/蓬勃发展的技能会议，以发展的态度，技能和行为的富有成效的，询问，和道德的科学家在合作团队沿着职业道路工作。将根据正在进行的进程和程序，对参与者和项目进行广泛的短期/长期形成性和总结性评价，并在全国范围内传播成功的模式和产品，以便在其他环境中推广。

DESCRIPTION (provided by applicant): "Summers in Children's Research" (SCR) at The University of Arizona Health Sciences Center, Steele Children's Research Center, and Diamond Children's Medical Center will offer annually 8 diverse junior/senior high school students and 4 continuing undergraduates from Arizona an exciting educational 8-12 week summer experience in "hands on, brain on" basic and clinical research broadly targeting childhood and developmental disorders and maternal health and health disparities. The multidisciplinary project leadership team includes an internationally renowned pediatrician specialized in children's gastrointestinal disorders (molecular mechanisms and clinical management) joined by an obstetrician-gynecologist focused on community/public health/health disparities, along with an expert in childhood and developmental lymphatic disorders, diversity pipeline research training, and inquiry curriculum innovation. They will together interact with vibrant clinical and basic research programs impacting children's and maternal health. Based on the College of Medicine's highly successful longstanding federally funded multidisciplinary disadvantaged high school student research program drawing large numbers of qualified applicants from around Arizona and also a locally supported Department of Pediatrics high school student summer program, this project will stepwise develop a distinctive SCR curriculum including online components and expanded research experiences encompassing the NICHD mission. Research topics and full-time summer research experiences will range from molecular mechanisms of calcium/phosphate absorption in inflammatory bowel disease and infant diarrheal disorders to genomics and proteomics of Niemann-Pick C disease, epidemiology of pediatric head trauma and substance abuse, and field work in maternal health and sexually transmitted diseases. SCR will involve experienced, enthusiastic faculty and near-peer mentors not only in Pediatrics but broadly representing basic and clinical research impacting children and reproduction and spanning NICHD research directions. The specialized SCR summer curriculum will be incorporated into an innovative face-to-face and online inquiry-based Summer Institute on Medical Ignorance (highlighting Unanswered Questions and Unquestioned Answers and reinforcing core content) for high school students (paralleling the PIs' medical student researcher offering) and features highly interactive elements and the PIs' unique Virtual Clinical Research Center/Questionarium. VCRC/Q is a web-based gridware platform designed to link NIH-CTSAs and GCRCs to the K-12 community, using advanced multimedia technology familiar to teenagers and younger children. The PIs will use peer and near-peer mentoring strategies and surviving/thriving skill sessions to develop attitudes, skills, and behaviors of fruitful, inquiring, and ethical scientists working in collaborative teams along career pathways. Extensive short-term/long-term formative and summative participant and project evaluation, based on ongoing processes and procedures, will be carried out, and successful models and products disseminated nationally for replication in other settings.