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A multiplex panel for simultaneously profiling toxicant levels and biological res

A multiplex panel for simultaneously profiling toxicant levels and biological res
用于同时分析毒物水平和生物研究的多重面板
批准号:
8433150
负责人:
Christopher Striemer
金额:
$24.59万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-02-18 至 2014-07-31

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中文摘要
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英文摘要
DESCRIPTION (provided by applicant): There is increasing interest in the exposure science field in top-down approaches to studying human environmental exposures (the exposome), where toxicants of interest are profiled within the body through blood and/or other biological samples. Such studies would complement more traditional bottom-up approaches where the environment in which an individual lives is sampled and studied to identify potential causes of disease. The long-term goal of the work proposed in this application is to create highly multiplex sensors to facilitate not only the detection of environmental toxicants in serum samples, but to also profile the immune or other biological response induced by these potential exposures. Through previous work funded by the NIEHS, Adarza BioSystems has developed a portable, multiplex protein detection system designed to profile biological response to toxic exposures from a finger-stick volume of blood. By measuring the levels of cytokines and other protein biomarkers, health status information related to inflammation, oxidative stress, and coagulation can be quickly assessed in the field using this tool, without the need for centralized laboratory facilities. In this application we seek to apply this core detection technology for the first time,to the direct detection of environmental toxicants linked to human disease. Specifically, a 5-plex array will be developed in Phase I that will target Bisphenol A, Triclosan, Benzo[a]pyrene, Napthalene, and Chlordane. Aim 1 will develop the required functional array probes that will be used to optimize the assay protocol in Aim 2. The detection sensitivity for all target compounds will then be measured in Aim 3. In a future Phase II effort, this demonstration array will be expanded with additional toxicant content and added to Adarza's existing environmental response biomarkers, creating a single detection platform that will simultaneously profile known toxicants and their biological response from a single drop of blood.
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A Rapid Label-free Sensor for Immune Markers of Environmental Exposure
  • 批准号:
    7797822
  • 项目类别:
  • 资助金额:
    $19.2万
  • 财政年份:
    2007
  • 负责人:
    Christopher Striemer
  • 依托单位:
A Rapid Label-free Sensor for Immune Markers of Environmental Exposure
  • 批准号:
    7363511
  • 项目类别:
  • 资助金额:
    $19.2万
  • 财政年份:
    2007
  • 负责人:
    Christopher Striemer
  • 依托单位:
A Rapid Label-free Sensor for Immune Markers of Environmental Exposure
  • 批准号:
    7676433
  • 项目类别:
  • 资助金额:
    $17.02万
  • 财政年份:
    2007
  • 负责人:
    Christopher Striemer
  • 依托单位:
A rapid label-free sensor for immune markers of environmental exposure for applic
  • 批准号:
    8391026
  • 项目类别:
  • 资助金额:
    $2.75万
  • 财政年份:
    2007
  • 负责人:
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国内基金
海外基金
Neo-antigens暴露对肾移植术后体液性排斥反应的影响及其机制研究
  • 批准号:
    2022J011295
  • 项目类别:
    省市级项目
  • 资助金额:
    10.0万元
  • 批准年份:
    2022
  • 负责人:
    王亚伟
  • 依托单位:
结核分枝杆菌持续感染期抗原(latency antigens)的重组BCG疫苗研究