Research Training in Environmental Toxicology

描述(由申请人提供) 在这份新的Ruth L.Kirschstein NRSA机构研究培训补助金申请中，研究人员申请资金支持加州大学河滨分校的环境毒理学研究培训。拟议的跨学科研究培训计划是基于环境毒理学研究生计划的现有课程结构。这12名导师来自化学、生物化学、环境和化学工程以及环境科学系。他们非常积极地参与了对环境毒理学博士后和博士后的培训，他们的研究项目得到了充足的资金。这些教员的研究项目包括遗传毒理学和环境致癌(Eastmond，Liu，Wang和朱)，空气污染研究，涉及检测和调查空气污染物和空气传播毒素的生物后果(程，Eastmond，Hille，Mulchandani，Wang和Ziemann)，以及受体介导的毒性(Adams，Gill，Schlenk和Sladek)。博士前实习生将从四个研究生课程中挑选出来，包括环境毒理学、生物化学和分子生物学、化学以及细胞、分子和发育生物学。设立了一个内部指导委员会，负责挑选受训人员并监测受训人员的进展情况。要求的培训名额不多，包括第一年的3名实习生(2名博士后，1名博士后)，第二年的5名实习生(3名博士前，2名博士后)，以及随后三年每年的6名实习生(4名博士后，2名博士后)。学员将接触到各种最先进的技术，包括纳米制造、基因组学、蛋白质组学等。申请这项研究培训拨款的理由是，拟议的研究培训与环境健康相关，良好的培训环境，导师在培训博士前和博士后方面的卓越经验，之前的学员的成功，强大的机构承诺，以及大学多样化的研究生群体。 相关性：这笔T32研究培训赠款的资金将用于培训在环境健康和毒理学领域工作的下一代科学家。

DESCRIPTION (provided by applicant) In this new Ruth L. Kirschstein NRSA Institutional Research Training Grant Application, the investigators request funds to support the research training in environmental toxicology at the University of California Riverside. The proposed interdisciplinary research training program is based on the existing curriculum structure of the environmental toxicology graduate program. The twelve preceptors are from the Departments of Chemistry, Biochemistry, Environmental and Chemical Engineering, as well as Environmental Sciences. They have been very actively involved with the training of pre- and postdoctoral individuals in environmental toxicology and their research projects have been well funded. The research programs of these faculty members include genetic toxicology and environmental carcinogenesis (Eastmond, Liu, Wang, and Zhu), air pollution research involving the detection and the investigation of the biological consequences of air pollutants and air-borne toxins (Cheng, Eastmond, Hille, Mulchandani, Wang, and Ziemann), and receptor-mediated toxicity (Adams, Gill, Schlenk, and Sladek). Pre-doctoral trainees will be selected from four graduate programs including Environmental Toxicology, Biochemistry and Molecular Biology, Chemistry, as well as Cellular, Molecular, and Developmental Biology. An Internal Steering Committee is established to select the trainees and to monitor the progress of the trainees. A modest number of training slots are requested, which include 3 trainees in the 1st year (2 pre-doctorates + 1 postdoctorate), 5 trainees in the 2nd year (3 pre-doctorates + 2 postdoctorates), and 6 trainees (4 pre-doctorates + 2 postdoctorates) in each of the following three years. The trainees will be exposed to a variety of state-of-the-art technologies including nanofabrication, genomics, proteomics, etc. The request for funding of this research training grant is justified by the relevance of the proposed research training to environmental health, the excellent training environment, the superb experience of the preceptors in training pre- and postdoctoral individuals, the success of the previous trainees, the strong institutional commitment, and the diverse graduate student body at the University. Relevance: The funding of this T32 research training grant will allow for the training of next-generation scientists working in the area of environmental health and toxicology.