Research Training in Environmental Toxicology

 描述（由申请人提供） 在 Ruth L. Kirschstein NRSA 机构研究培训拨款申请的竞争性更新中，我们请求资金支持加州大学河滨分校的环境毒理学研究培训。拟议的跨学科研究培训计划建立在环境毒理学研究生课程现有课程结构的坚实基础上。这十四位导师分别来自生物医学科学部以及化学系、生物化学系、植物学与植物科学系、化学与环境工程系、环境科学系。他们非常积极地参与环境毒理学博士前和博士后人员的培训，并且他们的研究项目得到了充足的资助。这些教师的研究项目包括遗传毒理学和表观遗传学（Chen、Eastmond、Song 和 Wang）、分析化学和蛋白质组学（Ai、Cheng、Gan、Mulchandani 和 Wang）、氧化应激（Ai、Julian 和 Wang）以及内分泌干扰和代谢（Gill、Messaoudi、Schlenk、Sladek 和 Walker）。博士前培训生将从参与的化学和环境毒理学研究生项目中选拔。成立了一个内部指导委员会来选择受训者并监督受训者的进度，还任命了一个外部顾问委员会来协助培训计划的管理。每年共招收 6 名学员（4 名博士前，2 名博士后）。学员将接触到纳米制造、基因组学、蛋白质组学等领域的各种尖端技术。 拟议的研究培训与环境健康的相关性、优良的培训环境、导师在培训博士前和博士后人员方面的精湛经验、强有力的机构承诺、大学多元化的研究生群体，以及我们在上一个资助周期中成功招募、任命和培养学员的成功，证明了继续资助这项研究培训补助金的合理性。

 DESCRIPTION (provided by applicant) In this competitive renewal of the Ruth L. Kirschstein NRSA Institutional Research Training Grant Application, we request funds to support the research training in environmental toxicology at the University of California, Riverside. The proposed interdisciplinary research training program is built upon the solid foundation of the existing curriculum structure of the environmental toxicology graduate program. The fourteen preceptors are from the Division of Biomedical Sciences as well as the Departments of Chemistry, Biochemistry, Botany and Plant Science, Chemical and Environmental Engineering, and Environmental Sciences. They have been very actively involved with the training of pre- and postdoctoral individuals in environmental toxicology and their research projects have been well funded. The research programs of these faculty members include genetic toxicology and epigenetics (Chen, Eastmond, Song, and Wang), analytical chemistry and proteomics (Ai, Cheng, Gan, Mulchandani, and Wang), oxidative stress (Ai, Julian and Wang), and endocrine disruption and metabolism (Gill, Messaoudi, Schlenk, Sladek, and Walker). Pre-doctoral trainees will be selected from the participating Chemistry and Environmental Toxicology graduate programs. An Internal Steering Committee is established to select the trainees and to monitor the progress of the trainees, and an External Advisory Board is also named to assist the management of the training program. A total of 6 trainees per year (4 pre-doctorates plus 2 post-doctorates) are requested. The trainees will be exposed to a variety of cutting-edge technologies in nanofabrication, genomics, proteomics, etc. The request for continuing funding of this research training grant is justified by the relevance of the proposed research training to environmental health, the excellent training environment, the superb experience of the preceptors in training pre- and postdoctoral individuals, the strong institutional commitment, the diverse graduate student body at the University, as well as our success in recruiting, appointing and nurturing the success of trainees in the last funding cycle.