Developmental Research (Ingle)

马约诊所乳腺癌SPORE将最大限度地提高发展研究计划中创新和高质量项目的数量。该计划的目标是支持创新的，科学上有价值的研究项目，这些研究结果可以转化为临床上重要的应用，这些应用将影响乳腺癌的诊断和管理，以减少这种疾病的负担和死亡率。该方案将：1）鼓励和征求创新的转化实验室，人口和临床研究建议; 2）鼓励和支持乳腺癌转化研究的跨学科合作; 3）产生新的假设，可以在大规模的研究项目或临床试验中进行测试，可以影响乳腺癌。这种支持的可用性为研究界的创造力提供了刺激，为鼓励基础科学家和翻译研究人员的互动提供了一种工具，并为扩大SPORE的研究范围提供了一个机会，即根据发现和/或出现的机会寻求新的线索。发展研究计划将为六个项目中的每一个项目提供为期一年的5万美元（25,000美元来自SPORE基金，25,000美元来自马约诊所癌症中心）。如果取得足够的进展，将有可能提供第二年的支助。在马约诊所乳腺癌孢子的初始拨款期间建立了一个过程，包括每年一次的申请呼吁和利用内部科学咨询委员会和其他经验丰富的研究人员的专业知识进行正式的同行评审。由于这一进程取得了成功，将继续这一进程。选择资助项目的标准是基于科学价值，原创性，申请人的资格和翻译潜力。预计对发展研究项目的支持将产生数据，这些数据将作为SPORE赞助的其他项目或通过同行审查的外部赠款支持提供支持的基础。SPORE领导层的目的是鼓励和帮助研究人员使用这些项目产生的数据来建立乳腺癌的临床前或临床试验。此外，SPORE领导层将与调查人员合作，以确保独立的R 01级资金。在本次SPORE更新的四个完整项目中，有两个项目的共同负责人是发展研究计划的获奖者，这表明发展研究计划在上一个资助期内在这方面取得了成功。

The Mayo Clinic Breast Cancer SPORE will maximize the number of innovative and high-quality projects in the Developmental Research Program. The goal of this program is to support innovative, scientifically meritorious research projects from which findings can be translated into clinically important applications that will impact diagnosis and management of breast cancer in order to decrease the burden and mortality from this disease. This program will: 1) encourage and solicit innovative translational laboratory, population, and clinical study proposals; 2) encourage and support interdisciplinary collaboration in translational research in breast cancer; and 3) generate new hypotheses that can be tested in larger-scale research projects or clinical trials that can impact breast cancer. The availability of this support provides a stimulus for creativity in the research community, a vehicle for encouraging the interaction of basic scientists and translational investigators, and an opportunity for expanding the research spectrum of the SPORE by pursuing new leads based on discoveries and/or opportunities that arise. The Developmental Research Program will provide $50,000 for one year ($25,000 from SPORE funds and a matching $25,000 from Mayo Clinic Cancer Center) to each of six projects. There will be the possibility of a second year of support based on demonstration of sufficient progress. A process was established during the initial grant for the Mayo Clinic Breast Cancer SPORE involving a call for applications on an annual basis and a formal peer review utilizing the expertise of the Internal Scientific Advisory Committee and other experienced investigators. Because of the success of this process, it will be continued. Criteria for selection of projects for funding are based upon scientific merit, originality, qualifications of the applicant, and translational potential. It is expected that support of developmental research projects will result in generation of data that will serve as the basis for additional SPORE-sponsored projects or support through peer reviewed external grant support. It is the intent of the SPORE leadership to encourage and help the investigators to use the data generated by these projects to establish preclinical or clinical trials in breast cancer. In addition the SPORE leadership will work with the investigators to secure independent R01-level funding. Two of the four full Projects in this SPORE renewal have a co-leader who was a Developmental Research Program awardee, which indicates that the Developmental Research Program has been successful in this regard during the previous funding period.