Developmental Research (Ingle)

梅奥诊所乳腺癌孢子将在发展研究计划中最大限度地增加创新和高质量项目的数量。该计划的目标是支持创新的、科学上有价值的研究项目，这些项目的研究成果可以转化为重要的临床应用，影响乳腺癌的诊断和管理，以减少这种疾病的负担和死亡率。该计划将：1)鼓励和征求创新的转化实验室，人口和临床研究提案；2)鼓励和支持乳腺癌转化研究的跨学科合作；3)产生新的假设，可以在影响乳腺癌的大规模研究项目或临床试验中进行测试。这种支持的可用性为研究界的创造力提供了刺激，鼓励基础科学家和转化研究人员之间的互动，并通过基于发现和/或出现的机会追求新的线索来扩大SPORE的研究范围。发展研究计划将为六个项目中的每一个提供5万美元，为期一年（其中2.5万美元来自《孢子》基金，另外2.5万美元来自梅奥诊所癌症中心）。有可能在取得足够进展的情况下提供第二年的支持。在梅奥诊所乳腺癌孢子项目的初始拨款期间，建立了一个程序，包括每年一次的申请，以及利用内部科学咨询委员会和其他经验丰富的研究人员的专业知识进行正式的同行评审。由于这一进程的成功，它将继续下去。资助项目的选择标准是基于科学价值、独创性、申请人的资格和转化潜力。预期对发展研究项目的支持将产生数据，这些数据将作为额外的spore赞助项目或通过同行审查的外部赠款支持提供支持的基础。SPORE领导层的目的是鼓励和帮助研究人员使用这些项目产生的数据来建立乳腺癌的临床前或临床试验。此外，SPORE领导层将与调查人员合作，以确保独立的r01级资金。在《孢子》续期的四个完整项目中，有两个项目的共同负责人是发展研究计划的获得者，这表明在之前的资助期间，发展研究计划在这方面取得了成功。

The Mayo Clinic Breast Cancer SPORE will maximize the number of innovative and high-quality projects in the Developmental Research Program. The goal of this program is to support innovative, scientifically meritorious research projects from which findings can be translated into clinically important applications that will impact diagnosis and management of breast cancer in order to decrease the burden and mortality from this disease. This program will: 1) encourage and solicit innovative translational laboratory, population, and clinical study proposals; 2) encourage and support interdisciplinary collaboration in translational research in breast cancer; and 3) generate new hypotheses that can be tested in larger-scale research projects or clinical trials that can impact breast cancer. The availability of this support provides a stimulus for creativity in the research community, a vehicle for encouraging the interaction of basic scientists and translational investigators, and an opportunity for expanding the research spectrum of the SPORE by pursuing new leads based on discoveries and/or opportunities that arise. The Developmental Research Program will provide $50,000 for one year ($25,000 from SPORE funds and a matching $25,000 from Mayo Clinic Cancer Center) to each of six projects. There will be the possibility of a second year of support based on demonstration of sufficient progress. A process was established during the initial grant for the Mayo Clinic Breast Cancer SPORE involving a call for applications on an annual basis and a formal peer review utilizing the expertise of the Internal Scientific Advisory Committee and other experienced investigators. Because of the success of this process, it will be continued. Criteria for selection of projects for funding are based upon scientific merit, originality, qualifications of the applicant, and translational potential. It is expected that support of developmental research projects will result in generation of data that will serve as the basis for additional SPORE-sponsored projects or support through peer reviewed external grant support. It is the intent of the SPORE leadership to encourage and help the investigators to use the data generated by these projects to establish preclinical or clinical trials in breast cancer. In addition the SPORE leadership will work with the investigators to secure independent R01-level funding. Two of the four full Projects in this SPORE renewal have a co-leader who was a Developmental Research Program awardee, which indicates that the Developmental Research Program has been successful in this regard during the previous funding period.