Methodology Core

拟建的加州大学旧金山分校多学科临床研究中心(MCRC)的方法学核心将作为MCRC所有项目和活动的枢纽，并使该中心能够继续其关于风湿病健康差异的研究计划。方法学核心的主要目标是推进加州大学旧金山分校风湿性疾病结果的临床研究，建立在当前MCRC期间开发的现有结构基础上，并通过额外的外部资金扩大。MCRC的一个关键组成部分是提供共享数据源，允许MCRC教职员工和受训人员进行跨学科合作和富有成效的研究计划。方法学核心的具体目标是：向使用多学科研究中心数据源的多学科研究中心项目和非多学科研究中心项目提供方法学和生物统计学方面的支持和监督；处理所有数据收集，包括培训和监督数据收集工作人员；管理和分发数据；就核心单位数据的适当分析战略提供指导；并在开发和完成研究项目方面为受训者和初级教师提供指导。 方法学核心单元内共享的主要数据来源是狼疮结果研究和类风湿性关节炎结果研究。这两项研究都是纵向的，纳入了调查访谈、病历审查、实验室分析、面对面评估和基因分型等不同的数据收集方式。这些队列在种族/民族、社会经济地位和主要语言方面是不同的。用西班牙语管理调查的能力扩大了MCRC了解系统性红斑狼疮和类风湿性关节炎发病、进展、医疗保健和结果差异的原因的能力。 方法学核心将通过广泛的活动来完成其培训使命，包括个人指导、应用方法的定期研讨会以及致力于风湿病临床研究的会议。方法论核心领导层在培养高质量的研究以及吸引和提升有才华的初级调查人员方面有着成功的记录。拟议的方法学核心的教育部分将继续支持我们的受训人员采用严格的研究方法，并促进寻求推进风湿病临床研究的研究人员之间的跨学科合作。

The Methodology Core of the proposed UCSF Multidisciplinary Clinical Research Center (MCRC) will serve as the hub for all MCRC projects and activities and allow the Center to pursue its program of research on health disparities in the rheumatic diseases. The primary goal of the Methodology Core is to advance clinical research at UCSF in outcomes of rheumatic conditions, building upon the existing structure developed during the current MCRC and expanded through additional extramural funding. A key component of the MCRC is the provision of shared data sources, allowing for cross-disciplinary collaborations and productive research programs of MCRC faculty and trainees. The specific aims of the Methodology Core are to: provide methodological and biostatistical support and oversight to MCRC projects and non-MCRC projects that use MCRC data sources; handle all data collection, including training and supervision of data collection staff; manage and distribute the data; provide guidance in appropriate analysis strategies for Core Unit data; and provide mentorship to trainees and junior faculty in developing and completing research projects. The shared primary data sources within the Methodology Core Unit are the Lupus Outcomes Study and the Rheumatoid Arthritis Outcomes Study. Both studies are longitudinal, incorporating such varied modalities of data collection as survey interviews, medical chart reviews, laboratory assays, in-person assessments, and genotyping. The cohorts are diverse in terms of race/ethnicity, socioeconomic status, and primary language The capacity to administer surveys in Spanish expands the MCRCs ability to understand the causes of disparities in onset, progression, health care, and outcomes of systemic lupus erythematosus and rheumatoid arthritis. The Methodology Core will fulfill its training mission through a broad range of activities, including individual mentorship, regular seminars in applied methods, and conferences devoted to clinical research in rheumatology. The Methodology Core leadership has a successful track record of fostering high quality research and attracting and advancing talented junior investigators. The educational component of the proposed Methodology Core will continue to support rigorous research methods in our trainees and foster collaborations across disciplines among investigators seeking to advance clinical research in rheumatology.