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中文摘要
翻译
拟议的UCSF多学科临床研究中心(MCRC)的方法论核心将作为所有MCRC项目和活动的中心,并允许该中心继续其关于风湿性疾病健康差异的研究计划。该方法核心的主要目标是推进在UCSF风湿性疾病的结果的临床研究,建立在现有的结构在当前MCRC期间开发,并通过额外的校外资金扩大。MCRC的一个关键组成部分是提供共享数据源,允许跨学科合作和MCRC教师和学员的生产性研究计划。方法核心的具体目标是:为多学科项目资源中心项目和使用多学科项目资源中心数据源的非多学科项目提供方法和生物统计支持和监督;处理所有数据收集工作,包括培训和监督数据收集工作人员;管理和分发数据;为核心单元数据的适当分析战略提供指导;并为学员和初级教师提供指导,以发展和完成研究项目。 方法学核心单元内共享的主要数据来源是狼疮结局研究和风湿性关节炎结局研究。这两项研究都是纵向的,结合了调查访谈、病历审查、实验室测定、亲自评估和基因分型等不同的数据收集方式。队列在种族/民族、社会经济地位和主要语言方面是多样的。用西班牙语进行调查的能力扩大了MCRC了解系统性红斑狼疮和类风湿性关节炎发病、进展、医疗保健和结局差异原因的能力。 方法学核心将通过广泛的活动履行其培训使命,包括个人指导,应用方法的定期研讨会,以及致力于流变学临床研究的会议。方法论核心领导层在促进高质量研究以及吸引和推动有才华的初级研究人员方面有着成功的记录。拟议的方法核心的教育部分将继续支持我们的学员严格的研究方法,并促进寻求推进风湿病学临床研究的研究者之间的跨学科合作。
英文摘要
The Methodology Core of the proposed UCSF Multidisciplinary Clinical Research Center (MCRC) will serve as the hub for all MCRC projects and activities and allow the Center to pursue its program of research on health disparities in the rheumatic diseases. The primary goal of the Methodology Core is to advance clinical research at UCSF in outcomes of rheumatic conditions, building upon the existing structure developed during the current MCRC and expanded through additional extramural funding. A key component of the MCRC is the provision of shared data sources, allowing for cross-disciplinary collaborations and productive research programs of MCRC faculty and trainees. The specific aims of the Methodology Core are to: provide methodological and biostatistical support and oversight to MCRC projects and non-MCRC projects that use MCRC data sources; handle all data collection, including training and supervision of data collection staff; manage and distribute the data; provide guidance in appropriate analysis strategies for Core Unit data; and provide mentorship to trainees and junior faculty in developing and completing research projects. The shared primary data sources within the Methodology Core Unit are the Lupus Outcomes Study and the Rheumatoid Arthritis Outcomes Study. Both studies are longitudinal, incorporating such varied modalities of data collection as survey interviews, medical chart reviews, laboratory assays, in-person assessments, and genotyping. The cohorts are diverse in terms of race/ethnicity, socioeconomic status, and primary language The capacity to administer surveys in Spanish expands the MCRCs ability to understand the causes of disparities in onset, progression, health care, and outcomes of systemic lupus erythematosus and rheumatoid arthritis. The Methodology Core will fulfill its training mission through a broad range of activities, including individual mentorship, regular seminars in applied methods, and conferences devoted to clinical research in rheumatology. The Methodology Core leadership has a successful track record of fostering high quality research and attracting and advancing talented junior investigators. The educational component of the proposed Methodology Core will continue to support rigorous research methods in our trainees and foster collaborations across disciplines among investigators seeking to advance clinical research in rheumatology.
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会议论文
Sleep Disturbance in Rheumatoid Arthritis: Phenotypes, Causes, and Impact
Sleep Disturbance in Rheumatoid Arthritis: Phenotypes, Causes, and Impact
Sleep Disturbance in Rheumatoid Arthritis: Phenotypes, Causes, and Impact
Human Subjects and Clinical Phenotyping Core
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海外基金
Molecular Interaction Reconstruction of Rheumatoid Arthritis Therapies Using Clinical Data