Therapeutically Applicable Research to Generate Effective Treatments (TARGET)

产生有效治疗方法的治疗应用研究（目标）

• 批准号: 8654778
• 负责人: DAVID HEIMBROOK
• 金额: $ 35万
• 依托单位: LEIDOS BIOMEDICAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2018-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8654778
• 关键词: Adult; Adverse effects; Cancer Therapy Evaluation Program; Child; Children' s Oncology Group; Chromosomes; Collaborations; DNA Resequencing; DNA Sequence; Data; Development; Gene Expression; Gene Expression Profile; Genes; Genetic; Genome; Genomics; Goals; Health; Malignant Childhood Neoplasm; Malignant Neoplasms; Methods; Molecular Target; Mutation; Office of Cancer Genomics; Outcome; RNA Interference; Reading; Research; Resolution; Sampling; Services; Structure; System; Techniques; The Cancer Genome Atlas; Translations; Ursidae Family; base; cancer genomics; cancer therapy; clinical application; effective therapy; novel; programs; structural genomics; therapeutic target

The goal of NCI's Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Initiative is to identify valid therapeutic targets in childhood cancers so that new, more effective treatments can be rapidly developed. TARGET is coordinated by the Office of Cancer Genomics (OCG) and the Cancer Therapy Evaluation Program (CTEP). There is an overwhelming need for new treatment approaches to childhood cancers. The early victories in health outcomes of the last several decades for children with cancer have slowed. Furthermore, the current treatments for childhood cancers can have serious short- and long-term side effects, and recent molecularly targeted therapy advances have been largely limited to the treatment of adult cancers. The TARGET Initiative seeks to help bring the new era of targeted cancer therapy to bear on the cancers that afflict children. In pursuing its goals, TARGET leverages the strengths of other NCI programs, including the Children's Oncology Group (COG), The Cancer Genome Atlas (TCGA), and the Strategic Partnership to Evaluate Cancer Signatures (SPECS). These collaborations should expedite the discovery of therapeutic targets and catalyze the translation of these findings for clinical application with the ultimate goal of reducing the burden of childhood cancer. SAIC obtains nextgen sequencing capabilities and procures data coordination services.

NCI的治疗应用研究产生有效治疗（TARGET）计划的目标是确定儿童癌症的有效治疗靶点，以便快速开发新的、更有效的治疗方法。TARGET由癌症基因组学办公室（OCG）和癌症治疗评估项目（CTEP）协调。