Knockout Mouse Facility

敲除小鼠设施

• 批准号: 8241822
• 负责人: DAVID HEIMBROOK
• 金额: $ 25.9万
• 依托单位: LEIDOS BIOMEDICAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2018-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8241822
• 关键词: Aging; Anxiety; Arthritis; Biological; Diabetes Mellitus; Genes; Genetic; Genetically Engineered Mouse; Heart Diseases; Human; Knock-out; Knockout Mice; Laboratory Animals; Malignant Neoplasms; Mus; National Cancer Institute; Obesity; Parkinson Disease; Pharmaceutical Preparations; Production; Research; Research Personnel; Services; Study models; Substance abuse problem; Techniques; Testing; homologous recombination; loss of function mutation; mouse model; research study

Mice are the laboratory animal species most closely related to humans in which the knockout technique can be easily performed, so they are a favorite subject for knockout experiments, especially with regard to genetic questions that relate to human The Knockout Mouse facility at the National Cancer Institute - Frederick provides services with the production of genetically engineered mouse models with loss-of-function mutation through homologous recombination. By removing a certain gene and studying the mouse for any resulting differences, researchers can infer the probable function of that particular gene. Examples of research in which knockout mice have been useful include studying and modeling different kinds of cancer, obesity, heart disease, diabetes, arthritis, substance abuse, anxiety, aging and Parkinson's disease. Knockout mice also offer a biological and scientific context in which drugs and other therapies can be developed and tested.

小鼠是与人类关系最密切的实验动物物种，敲除技术很容易进行，因此它们是敲除实验最喜欢的对象，特别是在与人类相关的遗传问题方面。国家癌症研究所的敲除小鼠设施 - Frederick 提供通过同源重组生产具有功能丧失突变的基因工程小鼠模型的服务。通过去除某个基因并研究小鼠的任何由此产生的差异，研究人员可以推断该特定基因的可能功能。基因敲除小鼠的有用研究例子包括研究和建模不同种类的癌症、肥胖症、心脏病、糖尿病、关节炎、药物滥用、焦虑、衰老和帕金森病。基因敲除小鼠还提供了可以开发和测试药物和其他疗法的生物学和科学背景。