NIEHS Nanomaterials characterization and informatics

NIEHS 纳米材料表征和信息学

• 批准号: 8429331
• 负责人: DAVID HEIMBROOK
• 金额: $ 2万
• 依托单位: LEIDOS BIOMEDICAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2018-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8429331
• 关键词: Area; Atomic Force Microscopy; Biological; Biological Models; Capillary Electrophoresis; Cells; Characteristics; Charge; Chemicals; Chemistry; Contracts; Coupled; Data; Electron Microscopy; Electrospray Ionization; Engineering; Exposure to; Field Flow Fractionation; Fluorescence; Health; High Pressure Liquid Chromatography; Hydrophobicity; Informatics; Laboratories; Lasers; Light; Liquid Chromatography; Literature; MALDI-TOF Mass Spectrometry; Mass Spectrum Analysis; Methods; Molecular; Molecular Sieve Chromatography; Molecular Weight; NMR Spectroscopy; Nanotechnology; National Institute of Environmental Health Sciences; Organ; Plasma; Porosity; Property; Publishing; Research; Research Personnel; Risk; Spectrum Analysis; Sterility; Surface; System; Techniques; Work; density; fast protein liquid chromatography; hydrophilicity; light scattering; nanomaterials; predictive modeling; programs; response

To derive a comprehensive understanding on the potential health risks associated with exposure to engineered nanomaterials (ENMs), a detailed understanding of the physical and chemical characteristics of the ENMs is critical. The majority of the published literature on the biological responses to ENMs does not provide detailed physicochemical characterization data to identify which of the material's characteristics are critical to observed biological responses. The effects of subtle changes in the physicochemical properties of ENMs (such as size, charge, hydrophobicity, surface chemistry, etc.) on the biological response are therefore largely unknown. A new $35M (over five years) research program (NIEHS Centers for Nanotechnology Health Implications Research, [NCNHIR]) established in 2010 is focused on developing an understanding of how physicochemical characteristics of ENMs influence their interactions with biological matrices at the cell, molecular and organ level, and how this information can be integrated to develop predictive modeling systems to assess potential health effects. The NCNHIR formed a consortium and the investigators will be working with a common set of ENMs along with project's proposed in their research plan. To facilitate access to these grantees and to get a standardized physicochemical characteristics data for the ENMs to be studied by this consortium NIEHS established a contract with Nanotechnology Characterization Laboratory (NCL) at NCI/SAIC Fredrick.

为了获得对与工程纳米材料（ENM）相关的潜在健康风险的全面了解，对ENM的物理和化学特征的详细了解至关重要。关于ENM的生物学反应的大多数已发表的文献没有提供详细的理化表征数据，以识别哪些材料的特征对于观察到的生物学反应至关重要。因此，ENM的物理化学特性（例如大小，电荷，疏水性，表面化学等）的细微变化对生物学反应的影响是未知的。 2010年建立的一项新的3500万美元（五年）研究计划（NIEHS的纳米技术健康意义研究中心[NCNHIR]）致力于发展对ENM的物理化学特征的理解，影响了他们与细胞上的生物矩阵的相互作用，分子和器官水平以及这种信息能够整合系统的影响系统。 NCNHIR组成了一个财团，调查人员将与他们的研究计划中的项目一起使用一套共同的ENMS。为了促进获得这些受赠人的访问，并获取该财团NIEHS研究的ENM的标准化物理学特征数据，在NCI/SAIC FREDRICK建立了与纳米技术特征实验室（NCL）的合同。