NIEHS Nanomaterials characterization and informatics

NIEHS 纳米材料表征和信息学

• 批准号: 8429331
• 负责人: DAVID HEIMBROOK
• 金额: $ 2万
• 依托单位: LEIDOS BIOMEDICAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2018-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8429331
• 关键词: Area; Atomic Force Microscopy; Biological; Biological Models; Capillary Electrophoresis; Cells; Characteristics; Charge; Chemicals; Chemistry; Contracts; Coupled; Data; Electron Microscopy; Electrospray Ionization; Engineering; Exposure to; Field Flow Fractionation; Fluorescence; Health; High Pressure Liquid Chromatography; Hydrophobicity; Informatics; Laboratories; Lasers; Light; Liquid Chromatography; Literature; MALDI-TOF Mass Spectrometry; Mass Spectrum Analysis; Methods; Molecular; Molecular Sieve Chromatography; Molecular Weight; NMR Spectroscopy; Nanotechnology; National Institute of Environmental Health Sciences; Organ; Plasma; Porosity; Property; Publishing; Research; Research Personnel; Risk; Spectrum Analysis; Sterility; Surface; System; Techniques; Work; density; fast protein liquid chromatography; hydrophilicity; light scattering; nanomaterials; predictive modeling; programs; response

To derive a comprehensive understanding on the potential health risks associated with exposure to engineered nanomaterials (ENMs), a detailed understanding of the physical and chemical characteristics of the ENMs is critical. The majority of the published literature on the biological responses to ENMs does not provide detailed physicochemical characterization data to identify which of the material's characteristics are critical to observed biological responses. The effects of subtle changes in the physicochemical properties of ENMs (such as size, charge, hydrophobicity, surface chemistry, etc.) on the biological response are therefore largely unknown. A new $35M (over five years) research program (NIEHS Centers for Nanotechnology Health Implications Research, [NCNHIR]) established in 2010 is focused on developing an understanding of how physicochemical characteristics of ENMs influence their interactions with biological matrices at the cell, molecular and organ level, and how this information can be integrated to develop predictive modeling systems to assess potential health effects. The NCNHIR formed a consortium and the investigators will be working with a common set of ENMs along with project's proposed in their research plan. To facilitate access to these grantees and to get a standardized physicochemical characteristics data for the ENMs to be studied by this consortium NIEHS established a contract with Nanotechnology Characterization Laboratory (NCL) at NCI/SAIC Fredrick.

为了全面了解与接触工程纳米材料 (ENM) 相关的潜在健康风险，详细了解 ENM 的物理和化学特性至关重要。大多数关于 ENM 生物反应的已发表文献没有提供详细的物理化学表征数据来确定哪些材料特性对于观察到的生物反应至关重要。因此，ENM 的物理化学性质（例如尺寸、电荷、疏水性、表面化学等）的细微变化对生物反应的影响在很大程度上是未知的。 2010 年设立的一项耗资 3500 万美元（五年）的新研究计划（NIEHS 纳米技术健康影响研究中心，[NCNHIR]）的重点是了解 ENM 的理化特性如何影响其与细胞、分子和器官水平上的生物基质的相互作用，以及如何整合这些信息来开发预测模型系统以评估潜在的健康影响。 NCNHIR 成立了一个联盟，研究人员将与一组通用的 ENM 以及研究计划中提出的项目一起工作。为了方便接触这些受资助者并获得该联盟要研究的 ENM 的标准化物理化学特性数据，NIEHS 与 NCI/SAIC Fredrick 的纳米技术表征实验室 (NCL) 签订了合同。