NIEHS Nanomaterials characterization and informatics

NIEHS 纳米材料表征和信息学

• 批准号: 8429331
• 负责人: DAVID HEIMBROOK
• 金额: $ 2万
• 依托单位: LEIDOS BIOMEDICAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2018-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8429331
• 关键词: Area; Atomic Force Microscopy; Biological; Biological Models; Capillary Electrophoresis; Cells; Characteristics; Charge; Chemicals; Chemistry; Contracts; Coupled; Data; Electron Microscopy; Electrospray Ionization; Engineering; Exposure to; Field Flow Fractionation; Fluorescence; Health; High Pressure Liquid Chromatography; Hydrophobicity; Informatics; Laboratories; Lasers; Light; Liquid Chromatography; Literature; MALDI-TOF Mass Spectrometry; Mass Spectrum Analysis; Methods; Molecular; Molecular Sieve Chromatography; Molecular Weight; NMR Spectroscopy; Nanotechnology; National Institute of Environmental Health Sciences; Organ; Plasma; Porosity; Property; Publishing; Research; Research Personnel; Risk; Spectrum Analysis; Sterility; Surface; System; Techniques; Work; density; fast protein liquid chromatography; hydrophilicity; light scattering; nanomaterials; predictive modeling; programs; response

To derive a comprehensive understanding on the potential health risks associated with exposure to engineered nanomaterials (ENMs), a detailed understanding of the physical and chemical characteristics of the ENMs is critical. The majority of the published literature on the biological responses to ENMs does not provide detailed physicochemical characterization data to identify which of the material's characteristics are critical to observed biological responses. The effects of subtle changes in the physicochemical properties of ENMs (such as size, charge, hydrophobicity, surface chemistry, etc.) on the biological response are therefore largely unknown. A new $35M (over five years) research program (NIEHS Centers for Nanotechnology Health Implications Research, [NCNHIR]) established in 2010 is focused on developing an understanding of how physicochemical characteristics of ENMs influence their interactions with biological matrices at the cell, molecular and organ level, and how this information can be integrated to develop predictive modeling systems to assess potential health effects. The NCNHIR formed a consortium and the investigators will be working with a common set of ENMs along with project's proposed in their research plan. To facilitate access to these grantees and to get a standardized physicochemical characteristics data for the ENMs to be studied by this consortium NIEHS established a contract with Nanotechnology Characterization Laboratory (NCL) at NCI/SAIC Fredrick.

为了全面了解与接触工程纳米材料（enm）相关的潜在健康风险，详细了解工程纳米材料的物理和化学特性至关重要。大多数已发表的关于ENMs生物反应的文献没有提供详细的物理化学表征数据，以确定哪些材料的特性对观察到的生物反应至关重要。因此，enm的物理化学性质（如尺寸、电荷、疏水性、表面化学等）的细微变化对生物反应的影响在很大程度上是未知的。2010年建立的一个新的3500万美元（5年以上）研究项目（NIEHS纳米技术健康影响研究中心，[NCNHIR]）的重点是了解纳米材料的物理化学特性如何影响它们在细胞、分子和器官水平上与生物基质的相互作用，以及如何将这些信息集成到开发预测建模系统中，以评估潜在的健康影响。NCNHIR组成了一个财团，研究人员将使用一套通用的enm以及他们研究计划中提出的项目。为了方便获得这些受助者，并为该联盟研究的enm获得标准化的物理化学特性数据，NIEHS与NCI/SAIC Fredrick的纳米技术表征实验室（NCL）签订了一份合同。