Image Analysis Laboratory - EML and OM combined

图像分析实验室 - EML 和 OM 结合

• 批准号: 8429264
• 负责人: DAVID HEIMBROOK
• 金额: $ 171万
• 依托单位: LEIDOS BIOMEDICAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2018-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8429264
• 关键词: Animals; Basic Science; Biological; Cells; Collaborations; Development; Image Analysis; Individual; Kinetics; Laboratories; Molecular; National Cancer Institute; Nuclear; Pathway interactions; Principal Investigator; Proteins; Quantitative Microscopy; Reporting; Research; Resources; Role; STAT3 gene; Sampling; Site Visit; Solid Neoplasm; Tissues; Translational Research; carcinogenesis; molecular scale

The Image Analysis Laboratory (IAL) at the National Cancer Institute - Frederick focuses research on quantitative microscopy for understanding carcinogenesis in solid tumors by analyzing the kinetics of molecular pathways in individual cells while cells remain in their tissue context. Research is done mostly by collaborations with multiple NCI principal investigators, with special emphasis on the cytoplasmic and nuclear roles of the protein STAT3. Technical developments also aim to provide an integrated resource for analysis of biological samples across multiple scales from molecular to the animal level, thus providing a seamless, bidirectional transition between basic and translational research. IAL received an outstanding site visit review in the early summer. Formerly EML and OM were reported seperately, but are now combined.

美国国家癌症研究所的图像分析实验室 (IAL) - Frederick 专注于定量显微镜研究，通过分析细胞保留在其组织环境中时单个细胞中分子途径的动力学来了解实体瘤的癌变过程。研究主要是与多个 NCI 主要研究人员合作完成的，特别强调蛋白质 STAT3 的细胞质和细胞核作用。技术发展还旨在为从分子到动物水平的多个尺度的生物样本分析提供综合资源，从而提供基础研究和转化研究之间的无缝、双向过渡。 IAL 在初夏获得了出色的现场考察评价。以前 EML 和 OM 是分开报告的，但现在合并了。