Genotyping for epidemiology studies

流行病学研究的基因分型

• 批准号: 8654773
• 负责人: DAVID HEIMBROOK
• 金额: $ 526.19万
• 依托单位: LEIDOS BIOMEDICAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2018-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8654773
• 关键词: Affect; Area; Basic Science; Bioinformatics; Cancer Burden; Candidate Disease Gene; Caring; Cohort Studies; Communities; Custom; DNA; Data; Data Analyses; Data Set; Data Storage and Retrieval; Databases; Disease; Disease Outcome; Division of Cancer Epidemiology and Genetics; Electronics; Employment; Endometrial Carcinoma; Environmental Risk Factor; Epidemiologic Studies; Epidemiologist; Equipment and supply inventories; Etiology; European; Family; Generations; Genes; Genetic; Genetic Markers; Genetic Variation; Genome; Genomics; Genotype; Hodgkin Disease; Housing; Human; Human Genetics; Human Genome; Individual; Informatics; Information Management; Institution; Intramural Research Program; Investigation; Kaposi Sarcoma; Laboratories; Laboratory Research; Malignant Neoplasms; Malignant neoplasm of brain; Malignant neoplasm of cervix uteri; Malignant neoplasm of esophagus; Malignant neoplasm of larynx; Malignant neoplasm of liver; Malignant neoplasm of lung; Malignant neoplasm of ovary; Malignant neoplasm of pancreas; Malignant neoplasm of prostate; Malignant neoplasm of testis; Malignant neoplasm of thyroid; Malignant neoplasm of urinary bladder; Management Information Systems; Maps; Meta-Analysis; Metadata; Metric; Molecular Epidemiology; Mosaicism; Multiple Myeloma; Mutation; Non-Hodgkin' s Lymphoma; Outcome; Pathway interactions; Pattern; Phenotype; Population Genetics; Population Group; Predisposition; Preparation; Production; Proteomics; Publications; Quality Control; Rectal Cancer; Renal carcinoma; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Sampling; Scientific Advances and Accomplishments; Scientist; Skin Cancer; Solutions; Staging; Statistical Methods; Surveys; Techniques; Technology; Technology Transfer; Therapeutic Intervention; Uterine Cancer; Work; cancer genomics; college; cost; cost effective; database of Genotypes and Phenotypes; design; epidemiology study; exome; exome sequencing; follow-up; genetic analysis; genetic epidemiology; genetic variant; genome wide association study; improved; leukemia; malignant breast neoplasm; malignant stomach neoplasm; melanoma; new product development; next generation sequencing; novel; osteosarcoma; quality assurance; research and development; secondary outcome; tool

The Cancer Genomics Research (CGR) Laboratory was established to investigate the contribution of germline genetic variation to cancer susceptibility and outcomes. Working in concert with epidemiologists, biostatisticians and basic research scientists in the intramural research program, the CGR developed the capacity to conduct genome-wide association studies (GWAS), candidate gene approaches, and next-generation sequencing applications to identify the heritable determinants of various forms of cancer. In addition to offering the latest in genomics technology, the CGR has a fully integrated laboratory supporting several functional areas: DNA Extraction and Staging Laboratory (DESL) for preparation of samples; Laboratory Information Management System (LIMS) for advanced sample, project, and inventory, tracking; comprehensive project management; production laboratory; quality assurance and control; research and development for focused research projects and new product development; and bioinformatics and scientific analysis capabilities, making it a unique collaborative center for NCI-driven scientific endeavors.

癌症基因组学研究（CGR）实验室的建立是为了研究生殖系遗传变异对癌症易感性和结果的贡献。与流行病学家，生物统计学家和基础研究科学家在校内研究计划合作，CGR开发了进行全基因组关联研究（GWAS），候选基因方法和下一代测序应用的能力，以确定各种形式癌症的遗传决定因素。除了提供最新的基因组学技术外，CGR还拥有一个完全集成的实验室，支持几个功能领域：DNA提取和分期实验室（DESL）用于制备样品;实验室信息管理系统（LIMS）用于先进的样品，项目和库存，跟踪;全面的项目管理;生产实验室;质量保证和控制;重点研究项目和新产品开发的研究和开发;生物信息学和科学分析能力，使其成为一个独特的合作中心，为国家癌症研究所驱动的科学努力。