Genotyping for epidemiology studies

癌症基因组研究(CGR)实验室的建立是为了调查生殖系基因变异对癌症易感性和预后的贡献。CGR与流行病学家、生物统计学家和基础研究科学家在内部研究计划中合作，开发了进行全基因组关联研究(Gwas)、候选基因方法和下一代测序应用程序的能力，以确定各种形式癌症的可遗传决定因素。除了提供最新的基因组技术外，CGR还拥有一个全面集成的实验室，支持几个职能领域：DNA提取和分级实验室(DESL)，用于准备样本；实验室信息管理系统(LIMS)，用于高级样本、项目和库存、跟踪；综合项目管理；生产实验室；质量保证和控制；重点研究项目和新产品开发的研发；以及生物信息学和科学分析能力，使其成为NCI推动的科学努力的独特协作中心。

The Cancer Genomics Research (CGR) Laboratory was established to investigate the contribution of germline genetic variation to cancer susceptibility and outcomes. Working in concert with epidemiologists, biostatisticians and basic research scientists in the intramural research program, the CGR developed the capacity to conduct genome-wide association studies (GWAS), candidate gene approaches, and next-generation sequencing applications to identify the heritable determinants of various forms of cancer. In addition to offering the latest in genomics technology, the CGR has a fully integrated laboratory supporting several functional areas: DNA Extraction and Staging Laboratory (DESL) for preparation of samples; Laboratory Information Management System (LIMS) for advanced sample, project, and inventory, tracking; comprehensive project management; production laboratory; quality assurance and control; research and development for focused research projects and new product development; and bioinformatics and scientific analysis capabilities, making it a unique collaborative center for NCI-driven scientific endeavors.