Pilot Study on Mal de Debarquement

恶意离岸试点研究

• 批准号: 8496751
• 负责人: Mingjia Dai
• 金额: $ 20.13万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8496751
• 关键词: Affect; Age; Applications Grants; Characteristics; Coupled; Darkness; Data; Disorientation; Esthesia; Eye; Eye Movements; Fatigue; Figs - dietary; Forearm; Frequencies; Head; Head Movements; Headache; Illusions; Left; Measures; Methods; Motion; Motion Sickness; Movement; Nature; Oceans; Patients; Phase; Pilot Projects; Population; Positioning Attribute; Procedures; Property; Relative (related person); Rotation; Running; Stimulus; Symptoms; Syndrome; System; Testing; Therapeutic Uses; Time; Transportation; Vertical Nystagmus; Wrist; base; design; effective therapy; experience; eye velocity; insight; interest; oculomotor; research study; response; sensor; study characteristics; success; visual-vestibular

DESCRIPTION (provided by applicant): Mal de debarquement syndrome (MdDS) is an illusionary sensation of rocking, with symptoms that include disorientation, imbalance, headache and fatigue. While MdDS most often occurs after an ocean cruise, other forms of transportation can also cause it. The symptoms of MdDS can be transient (minutes) or persistent (years). At this time, neither the mechanisms nor treatment options for this condition exist. We propose that MdDS is triggered by unusual motion, where the rotation in one plane is coupled to the other. We also believe that there is a specific frequency of the stimulus that causes this unusual adaptation. These postulates can be tested by studying the characteristic responses of vestibular system. Our preliminary data has demonstrated that there are distinctive vestibular eye movements in MdDS patients, which are only apparent after experiencing the unusual motion. Furthermore, the frequency of rocking sensation in our patients is 0.2 Hz, which is also a critical frequency for provoking maximum motion sickness in normal population. With the determinants of eye movement and rocking frequency, we can design an effective treatment stimulus for MdDS patients with vestibular and visual interaction. Based on the results of our preliminary treatment, this method is robust. The aim of our proposal is to characterize the vestibular responses of MdDS patients and treat this devastating malady using the findings. We believe that our proposed study will provide new insights into a mysterious phenomenon that has been recognized since Darwin's age, and create a tangible treatment option for those affected by it.

描述（由申请人提供）：Mal de debarquement综合征（MdDS）是一种摇摆的错觉，症状包括定向障碍、失衡、头痛和疲劳。虽然MdDS最常发生在海上巡航之后，但其他形式的交通也可能导致它。MdDS的症状可能是短暂的（几分钟）或持续的（几年）。目前，这种情况的机制和治疗方案都不存在。我们建议，MdDS是由不寻常的运动，在一个平面中的旋转耦合到其他触发。我们还相信，有一个特定的刺激频率，导致这种不寻常的适应。这些假设可以通过研究前庭系统的特征反应来检验。我们的初步数据表明，有独特的前庭眼球运动在MdDS患者，这是明显的，只有经历了不寻常的运动。此外，我们的患者的摇摆感的频率为0.2 Hz，这也是正常人群中引起最大运动病的临界频率。有了眼动和摇摆频率的决定因素，我们可以设计一个有效的治疗刺激与前庭和视觉的互动MdDS患者。根据我们的初步处理结果，该方法是稳健的。我们建议的目的是描述MdDS患者的前庭反应，并使用这些发现治疗这种毁灭性的疾病。我们相信，我们提出的研究将为自达尔文时代以来就被认识到的神秘现象提供新的见解，并为受其影响的人创造一种切实可行的治疗方案。