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Development of Externalizing Behavior Problems: Gene-Environment Interplay

外化行为问题的发展：基因与环境的相互作用

基本信息

批准号：
8502363
负责人：
Laura A Baker
金额：
$ 68.97万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-01-05 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8502363
关键词：
18 year old Address Adolescence Adolescent Adult Affect Age Aggressive behavior Alcohol or Other Drugs use Antisocial Personality Disorder Behavior Behavior assessment Behavioral Biological Boxing Candidate Disease Gene Childhood Data Development Disease Disinhibition Drops Environment Environmental Risk Factor Etiology Female Funding Future Gender Genes Genetic Growth Individual Investigation Laboratories Longevity Measures Mental Health Mental disorders Modeling Nature Neurocognitive Outcome Pattern Phase Play Prevention Preventive Intervention Problem behavior Process Psychopathology Psychophysiology Public Health Quantitative Genetics Risk Risk Factors Sampling Societies Source Specific qualifier value Subgroup Substance abuse problem Testing Time Twin Multiple Birth Twin Studies anti social base cohort cost criminal offending critical period design deviant early childhood early onset emerging adult externalizing behavior genetic analysis high risk informant instrument life course persistent male neurophysiology offender peer prospective psychologic psychopathic personality social trait young adult

项目摘要

DESCRIPTION (provided by applicant): The present study is a continuation into adulthood of a major longitudinal twin study of aggression and antisocial behavior (ASB) and its social and biological risk factors (#MH58354) in a diverse urban sample. The first two funding periods provided comprehensive laboratory assessments of behavioral, neurocognitive, social and psychophysiological function, and multi-trait, multi-rater assessments of externalizing psychopathology during four waves of investigation when the twins were ages 9-10 (Wave 1) 11-13 (Wave 2), 14-16 (Wave 3) and 17-18 years old (Wave 4). Relationships of ASB with known risk factors (social and biological) were confirmed, and new relationships identified. The extent to which genetic and environmental factors affect ASB, its risk factors and their relationships has also been elucidated, with many findings shown to vary across gender, informant, definition of ASB, and age. We propose to extend the study to include an adult assessment at ages 19-23 (Wave 5), to obtain comprehensive measures of antisocial and aggressive behavior and their risk factors during a period of greatest risk for criminal offending, antisocial personality disorder and substance abuse. The primary aim of the next phase is to understand environmental, genetic, and phenotypic continuities in externalizing behavior problems and their biological and social risk factors through adulthood, including the prediction of adult outcomes from childhood and adolescent measures. Adding the adult assessment will yield the most comprehensive, prospective longitudinal data on externalizing behavior problems ever obtained in a genetically informative design. This five-wave, 15 year longitudinal twin study will provide the unique opportunity to understand how genes and environment combine and interact to produce antisocial outcomes from childhood to adulthood, and will greatly enhance our understanding of externalizing psychopathology and its heterogeneous developmental trajectories. Understanding gene-environment interplay in the development of externalizing psychopathology is of key importance to future intervention and prevention.

描述（由申请人提供）：本研究是在不同城市样本中对攻击和反社会行为（ASB）及其社会和生物风险因素（#MH58354）的主要纵向双胞胎研究的延续，直至成年。前两个资助期在双胞胎9-10岁（第1波）、11-13岁（第2波）、14-16岁（第3波）和17-18岁（第4波）的四波调查中，对行为、神经认知、社会和心理生理功能进行了全面的实验室评估，并对外化精神病理学进行了多特征、多评分评估。ASB与已知危险因素（社会和生物学）的关系得到确认，并发现新的关系。遗传和环境因素对ASB的影响程度、其风险因素及其关系也已得到阐明，许多研究结果显示，在性别、信息提供者、ASB定义和年龄方面存在差异。我们建议将研究扩展到包括19-23岁的成人评估（第五阶段），以获得反社会和攻击行为及其在犯罪，反社会人格障碍和药物滥用最危险时期的风险因素的综合测量。下一阶段的主要目标是了解外化行为问题及其生物和社会风险因素在成年期的环境、遗传和表型连续性，包括从童年和青少年测量中预测成年结果。加上成人的评估将产生最全面的，前瞻性的纵向数据外化行为问题，曾经在遗传信息设计中获得。这项为期15年的五波纵向双胞胎研究将为了解基因和环境如何结合和相互作用以产生从童年到成年的反社会结果提供独特的机会，并将极大地增强我们对外化精神病理学及其异质发展轨迹的理解。了解外化精神病理发展过程中基因与环境的相互作用对今后的干预和预防具有重要意义。