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2010 Cold Spring Harbor Laboratory Conference on Systems Biology: Global Regulati

2010年冷泉港实验室系统生物学会议：全球监管

基本信息

批准号：
8034857
负责人：
DAVID J. STEWART
金额：
$ 0.5万
依托单位：
COLD SPRING HARBOR LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-03-01 至 2015-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8034857
关键词：
Address Architecture Bioinformatics Biological Biological Models Biology Cells Chromatin Structure Collaborations Complex Computers DNA DNA Binding DNA Modification Process DNA Sequence DNA Structure Development Discipline Disease Educational workshop Elements Emerging Technologies Enhancers Epigenetic Process Eukaryota Eukaryotic Cell Evolution Female Functional RNA Funding Gene Expression Gene Expression Regulation Genes Genome Genomics Human Genome International Investigation Knowledge Laboratories Length Light Logic Malignant Neoplasms Molecular Nuclear Nucleosomes Oral Organism Participant Pattern Phylogenetic Analysis Post-Transcriptional Regulation Postdoctoral Fellow Process Proteins RNA-Protein Interaction Regulation Regulator Genes Regulatory Element Research Research Personnel Scientist Sequence Analysis Series Students Switch Genes Systems Biology Technology Terminology Time Transcript Transcriptional Regulation United States National Institutes of Health Variant Woman abstracting acronyms career chromatin modification design gene discovery genetic regulatory protein genome sequencing meetings next generation novel strategies posters preference promoter symposium transcription factor

项目摘要

Systems Biology: Global Regulation of Gene Expression Conference This proposal seeks NIH funding to support the seventh in a series of scientific meetings on systems biology approaches to understanding gene regulation in eukaryotes. The proposed 2010 meeting will focus on five key aspects of gene regulation¿cis-regulatory logic, transcriptional regulatory networks, nucleosomes and epigenetics, post-transcriptional regulation, and variation and evolution of regulatory networks. In addition, a session will be devoted to emerging technologies for analysis of gene regulation. The 2012 and 2014 meetings will follow a similar format and will include topics highly relevant to the current research at the time of the meeting. How cells control gene expression is a fundamental problem in biology. Ever since the discovery of the genes and the double strand helix structure of the DNA, there have been continuous investigations into this problem. Many great discoveries have been made, including the nuclear machineries that make transcripts as well as the DNA sequences that serve to control gene expression. Despite these efforts, our knowledge of the molecular mechanisms of gene regulation remains sketchy. For example, the transcriptional regulatory sequences and the regulatory proteins for most genes in the human genome are still poorly defined, despite the availability of the complete genome sequences. Now, with the amount of genome sequence information for various organisms rapidly growing, the problem has become ever more pressing. Traditionally, investigators have studied gene regulation by analyzing the DNA-binding preferences of specific transcription factors and/or the cis-regulatory elements that control the expression patterns of single genes. These studies have tentatively identified DNA sequence motifs for around one hundred transcription factors, and have led to the idea that transcriptional regulation at the genome level involves a complex interplay between modular DNA sequence elements such as enhancers, silencers, insulators, and basal promoter elements. The last several years have seen rapid advances in the development of new genomics approaches to analysis of each step of the gene expression. Many of these approaches involve a computational component in their design or interpretation. Other strategies have evolved from the availability of several complete genomic sequences and the prospects of many more to come. These include analyses of sequence conservation among closely related species to detect ¿phylogenetic footprints¿ in non-coding regions and the use of genomic microarrays and next-generation sequencing technologies to study DNA-protein and RNA-protein interactions. The results from these new approaches have provided unprecedented details on the gene regulatory processes in prokaryotic as well as eukaryotic cells. It is clear that effective collaborations between experimental and computational biologists will be required to come to grips with the complex problem of gene regulation. Thus we propose to conduct a meeting to permit a free cross-disciplinary exchange of existing ideas and expertise. It is hoped that this meeting will provide a mechanism for the establishment of new collaborations, and a forum for discussing new experimental and computational approaches. The meeting will be held at Cold Spring Harbor Laboratory on March 23-27, 2010. Twenty-two speakers of international renown have been invited to give oral presentations, and approximately forty-five others will be selected from submitted abstracts from applicants to the meeting. With the exception of the keynote address, oral presentations will be 15¿ in length with 5¿ for questions and discussions. Poster sessions will be included to encourage meaningful participation by the non-speaking attendees. In addition, we will hold pre-meeting workshops which will familiarize molecular biologists and bioinformaticians with the key concepts, terminology and acronyms needed to understand each others¿ disciplines. We expect attendance of approximately 250-300 scientists at the meeting. We particularly encourage female scientists and junior investigators to participate ¿ one of the two keynote speakers, 25% of the remaining invited speakers, and two of the four meeting organizers are women, and the majority of the participants in previous years have been students, postdocs or investigators in their early independent career.

系统生物学：全球基因表达调控会议