IGF::OT::IGF NHP TISSUE BANK

IGF::OT::IGF NHP 组织库

• 批准号: 8742069
• 负责人: Joseph W. Kemnitz
• 金额: $ 10.06万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2014-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8742069
• 关键词: Animal Housing; Animals; Archives; Communities; Ensure; Freezing; Human; Macaca mulatta; Modeling; Molecular; Protocols documentation; Research; Research Personnel; Resources; Techniques; Testing; Tissue Banking; Tissue Banks; Tissues; aged; nonhuman primate; sample fixation

This will provide a new research resource to many investigators and contribute to a reduction in the number of NHP needed by the research community since multiple investigators will be able to take advantage of each animal. The tissue will allow investigators to test hypotheses in a model closely related to humans by providing access to NHP tissue without the expense of obtaining and housing the animals. This is an extremely important aspect of this project, as the supply of NHP in general, and rhesus macaques in particular, is very limited. The tissues will be collected under strictly controlled protocols to ensure the integrity of the tissue. Tissue will be flash-frozen without fixation or fixed and embedded, to fit the needs of a wide-range of molecular and histochemical techniques.

这将为许多研究人员提供新的研究资源，并有助于减少研究界所需的NHP数量，因为多名研究人员将能够利用每种动物。该组织将允许研究人员在与人类密切相关的模型中测试假设，方法是提供获取NHP组织的途径，而不需要花费获取和安置动物的费用。这是该项目极其重要的一个方面，因为总体上国家淘汰计划的供应，特别是恒河猴的供应非常有限。这些组织将在严格受控的方案下收集，以确保组织的完整性。组织将被快速冷冻而不固定或固定并嵌入，以适应广泛的分子和组织化学技术的需要。