STEM CELL & REGENERATIVE MEDICINE CENTER NONHUMAN PRIMATES CORE

干细胞

• 批准号: 8173121
• 负责人: Joseph W. Kemnitz
• 金额: $ 4.13万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173121
• 关键词: Adverse effects; Animal Husbandry; Animals; Cell Therapy; Cells; Clinical assessments; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Human; Implant; In Vitro; Institution; Monkeys; Operative Surgical Procedures; Primates; Procedures; Publications; Regenerative Medicine; Replacement Therapy; Research; Research Personnel; Resources; Services; Source; Stem cells; Tissues; United States National Institutes of Health; Wisconsin; efficacy testing; instrument; laboratory facility; nonhuman primate; tissue preparation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To test efficacy and assess possible side effects of stem cell based therapies before proceeding to human trials. This service began in July 2007, with the launch of the new UW-Madison Stem Cell & Regenerative Medicine Center. Projects to develop cell replacement therapies may require that researchers study primate cells in vitro or implant stem cells into nonhuman primates to test efficacy and assess possible side effects before proceeding to human trials. In this context, expertise, laboratory facilities and animals are made available through the Nonhuman Primate Services core at the Wisconsin National Primate Research Center. Specific services include the provision of appropriate monkeys and primate tissue for projects, specialized animal husbandry, assistance with procedures such as surgeries and clinical assessments of monkeys, appropriate terminal procedures and preparation of tissues for analysis, and provision of specialized instruments. Numerous publications rely on WNPRC core stem cell services.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：在进行人体试验之前，测试基于干细胞的疗法的疗效并评估其可能的副作用。 这项服务开始于2007年7月，随着新的威斯康星大学麦迪逊分校干细胞和再生医学中心的推出。开发细胞替代疗法的项目可能需要研究人员在体外研究灵长类动物细胞，或将干细胞植入非人类灵长类动物体内，以测试疗效并评估可能的副作用，然后再进行人体试验。在这种情况下，专业知识，实验室设施和动物是通过非人类灵长类动物服务中心在威斯康星州国家灵长类动物研究中心的核心。具体服务包括为项目提供适当的猴子和灵长类动物组织、专门的畜牧业、协助进行手术和猴子临床评估等程序、适当的临终程序和准备用于分析的组织，以及提供专门仪器。 许多出版物依赖于WNPRC核心干细胞服务。