Oregon Alzheimer's Disease Center

俄勒冈阿尔茨海默病中心

• 批准号: 8460016
• 负责人: JEFFREY A KAYE
• 金额: $ 128.58万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8460016
• 关键词: African American; Aged, 80 and over; Aging; Alzheimer' s Disease; Area; Biochemical; Biochemistry; Biological Markers; Clinical; Collaborations; Communities; Core Facility; DNA; Data; Dementia; Diagnosis; Education; Elderly; Environment; Family; Future; Genetic; Genetic Markers; Genomics; Goals; Health; Homes for the Aged; Human Resources; Impaired cognition; Information Dissemination; Internet; Investigation; Knowledge; Knowledge Discovery; Link; Oregon; Pacific Northwest; Plasma; Population; Professional Education; Proteins; Research; Research Infrastructure; Research Personnel; Research Subjects; Resources; Rural Population; Technology; Time; Tissues; Translating; Treatment Protocols; Universities; Washington; Work; aging brain; base; data management; design; empowered; high risk; insight; interest; meetings; mild cognitive impairment; neuropathology; normal aging; novel; programs; relational database; social; statistics; symposium; tissue resource; tool

DESCRIPTION (provided by applicant): The Oregon Alzheimer's Disease Center's (OADC) goal is to facilitate and advance research on Alzheimer's disease (AD) and related topics, concentrating our efforts to better define normal aging, the transitions to mild cognitive impairment (MCI) and early dementia. This is achieved by maintaining six Core facilities in association with expert Core personnel to support current research strengths and to be responsive to new knowledge and discoveries in the field. The OADC is coordinated by the Administrative Core to be an efficient unit, working in concert with the research community to facilitate investigation in several major thematic areas such as studies of presymptomatic AD in the very elderly, biomarkers and the genetics of healthy brain aging, home-based technologies for real-time data capture and novel treatment regimens. The Clinical Core provides well-characterized, longitudinally followed research subjects of several kinds: 1) early AD and related dementias; 2) non-cognitively impaired or MCI elderly at high risk for dementia, emphasizing the oldest old; and 3) subjects reflecting social and racial diversity (African American and isolated rural populations). The Neuropathology Core is organized to maximize standardized diagnosis, availability of normative and MCI tissue, provision of state of the art protein marker biochemistry and research collaboration through the Pacific Northwest Dementia and Aging (PANDA) Neuropathology Group, a cooperative effort of the OADC and University of Washington ADC Neuropathology Cores. The Biomarkers and Genetics Core responds to the needs of this research using its bank of plasma, CSF and DNA for sophisticated characterization of research subjects toward developing markers of early AD. The Genetics Core also uniquely informs this research by sharing its biomarker and genomic resource widely with others interested in healthy brain aging. The Data Management and Statistics Core links all units with an efficient relational database creating a seamless path to ongoing and future collaborations with the National Alzheimer's Coordinating Center and other ADCs. The Data Core also provides important assistance and advice in design and statistical analysis to investigators. New information and knowledge of the field is disseminated through the Education and Information Core. This Core uses a variety of educational forums for information dissemination including small seminars, the Internet, and a large public symposium. The Core's professional education programs emphasize empowering front-line clinicians to meet the challenge of insuring optimal brain aging for our senior population.

描述（由申请人提供）：俄勒冈州阿尔茨海默病中心（OADC）的目标是促进和推进阿尔茨海默病（AD）和相关主题的研究，集中我们的努力，以更好地定义正常衰老，过渡到轻度认知障碍（MCI）和早期痴呆症。这是通过保持六个核心设施与专家核心人员相关联，以支持当前的研究优势，并对该领域的新知识和发现作出反应来实现的。OADC由行政核心协调，是一个高效的单位，与研究界合作，以促进几个主要主题领域的研究，如老年人症状前AD的研究，健康大脑老化的生物标志物和遗传学，用于实时数据采集的家庭技术和新的治疗方案。临床核心提供了几种类型的特征良好的纵向随访研究受试者：1）早期AD和相关痴呆; 2）非认知功能受损或MCI老年人痴呆高风险，强调最年长的老年人; 3）反映社会和种族多样性的受试者（非裔美国人和孤立的农村人口）。神经病理学核心的组织，以最大限度地标准化诊断，规范和MCI组织的可用性，提供最先进的蛋白质标记物生物化学和研究合作，通过太平洋西北痴呆症和老龄化（PANDA）神经病理学组，OADC和华盛顿大学ADC神经病理学核心的合作努力。生物标志物和遗传学核心响应这项研究的需要，使用其血浆，CSF和DNA库对研究对象进行复杂的表征，以开发早期AD的标志物。遗传学核心还通过与其他对健康大脑衰老感兴趣的人广泛分享其生物标志物和基因组资源，为这项研究提供了独特的信息。数据管理和统计核心将所有单位与高效的关系数据库联系起来，为与国家阿尔茨海默氏症协调中心和其他ADC的持续和未来合作创造了一条无缝的路径。数据核心还为调查人员提供设计和统计分析方面的重要帮助和建议。该领域的新信息和知识通过教育和信息中心传播。该核心利用各种教育论坛进行信息传播，包括小型研讨会、互联网和大型公共研讨会。核心的专业教育计划强调授权一线临床医生，以满足确保我们的老年人口的最佳大脑老化的挑战。