Oregon Alzheimer's Disease Center

描述（由申请人提供）：俄勒冈阿尔茨海默病中心（OADC）的目标是促进和推进阿尔茨海默病（AD）及相关主题的研究，集中精力更好地定义正常衰老、向轻度认知障碍（MCI）过渡和早期痴呆。这是通过与专家核心人员一起维护六个核心设施来实现的，以支持当前的研究优势，并对该领域的新知识和发现做出反应。OADC由行政核心协调，是一个高效的单位，与研究界协同工作，促进几个主要专题领域的研究，如老年痴呆症症状前的研究、健康大脑老化的生物标志物和遗传学、实时数据采集的家庭技术和新的治疗方案。临床核心提供了几类特征明确、纵向跟踪的研究对象：1)早期AD及相关痴呆；2)无认知功能障碍或轻度认知障碍的老年痴呆高危人群，以年龄最大者为主；3)反映社会和种族多样性的科目（非裔美国人和偏远农村人口）。神经病理学核心的组织是为了最大限度地实现标准化诊断，提供规范和MCI组织，提供最先进的蛋白质标记生物化学，并通过太平洋西北痴呆和衰老（PANDA）神经病理学小组进行研究合作，这是OADC和华盛顿大学ADC神经病理学核心的合作努力。生物标志物和遗传学核心响应了这项研究的需要，利用其血浆、脑脊液和DNA库对研究对象进行复杂的表征，以开发早期阿尔茨海默病的标志物。遗传学核心还通过与其他对健康大脑衰老感兴趣的人广泛分享其生物标志物和基因组资源，为这项研究提供了独特的信息。数据管理和统计核心通过一个高效的关系数据库将所有单位联系起来，为与国家阿尔茨海默病协调中心和其他adc进行的和未来的合作创造了无缝的途径。数据核心还向调查人员提供设计和统计分析方面的重要协助和建议。该领域的新信息和知识通过教育和信息核心传播。该核心利用各种教育论坛进行信息传播，包括小型研讨会、互联网和大型公共研讨会。核心的专业教育项目强调赋予一线临床医生能力，以应对确保老年人最佳大脑衰老的挑战。

DESCRIPTION (provided by applicant): The Oregon Alzheimer's Disease Center's (OADC) goal is to facilitate and advance research on Alzheimer's disease (AD) and related topics, concentrating our efforts to better define normal aging, the transitions to mild cognitive impairment (MCI) and early dementia. This is achieved by maintaining six Core facilities in association with expert Core personnel to support current research strengths and to be responsive to new knowledge and discoveries in the field. The OADC is coordinated by the Administrative Core to be an efficient unit, working in concert with the research community to facilitate investigation in several major thematic areas such as studies of presymptomatic AD in the very elderly, biomarkers and the genetics of healthy brain aging, home-based technologies for real-time data capture and novel treatment regimens. The Clinical Core provides well-characterized, longitudinally followed research subjects of several kinds: 1) early AD and related dementias; 2) non-cognitively impaired or MCI elderly at high risk for dementia, emphasizing the oldest old; and 3) subjects reflecting social and racial diversity (African American and isolated rural populations). The Neuropathology Core is organized to maximize standardized diagnosis, availability of normative and MCI tissue, provision of state of the art protein marker biochemistry and research collaboration through the Pacific Northwest Dementia and Aging (PANDA) Neuropathology Group, a cooperative effort of the OADC and University of Washington ADC Neuropathology Cores. The Biomarkers and Genetics Core responds to the needs of this research using its bank of plasma, CSF and DNA for sophisticated characterization of research subjects toward developing markers of early AD. The Genetics Core also uniquely informs this research by sharing its biomarker and genomic resource widely with others interested in healthy brain aging. The Data Management and Statistics Core links all units with an efficient relational database creating a seamless path to ongoing and future collaborations with the National Alzheimer's Coordinating Center and other ADCs. The Data Core also provides important assistance and advice in design and statistical analysis to investigators. New information and knowledge of the field is disseminated through the Education and Information Core. This Core uses a variety of educational forums for information dissemination including small seminars, the Internet, and a large public symposium. The Core's professional education programs emphasize empowering front-line clinicians to meet the challenge of insuring optimal brain aging for our senior population.