Spinal Circuits and the Musculoskeletal System

脊柱回路和肌肉骨骼系统

• 批准号: 8063424
• 负责人: Arthur W. English
• 金额: $ 16.92万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8063424
• 关键词: Acute; Biological Models; Biological Preservation; Biomechanics; Chronic; Clinical; Connective Tissue; Cutaneous; Disabled Persons; Effectiveness; Feedback; Felis catus; Financial compensation; Flexor; Goals; Individual; Kinetics; Modeling; Muscle; Musculoskeletal System; Nature; Nerve; Neuroanatomy; Operant Conditioning; Operative Surgical Procedures; Output; Peripheral Nerves; Persons; Physical therapy; Play; Program Research Project Grants; Protocols documentation; Ramp; Rattus; Recovery; Reflex action; Rehabilitation therapy; Research; Research Training; Role; Science; Scientist; Spinal; Training; axon regeneration; base; body system; career; experience; functional restoration; injured; interest; kinematics; neurophysiology; programs; reinnervation; repaired; research study; sciatic nerve; sensory system; spinal reflex

This proposal is for a Program Project Grant consisting of three Projects and three Cores. Its overall goal will be to evaluate the limits of adaptive changes in the relationship between spinal circuits and the musculoskeletal system when this interaction is disrupted. In each of the projects this disruption will be studied in model systems using transection and surgical repair of peripheral nerves. In Project I (English), the capacity for spontaneous adaptation, the effects of treadmill training, and operant conditioning of spinal reflexes on the outputs of spinal circuits will be studied after sciatic nerve transection in rats. The effectiveness of combining these approaches with protocols known to enhance the early regeneration of axons in injured peripheral nerves will be determined. In Project II (Gregor), the roles of short term compensatory strategies on longer term adaptive changes will be studied after transection and surgical repair of a single muscle nerve in cats. Using kinetic, kinematic, and EMG analyses, the extent of compensation by connective tissues, the effects of enhancing axon regeneration, and the roles played by cutaneous sensory systems in these changes will be studied. In Project III (Nichols), the roles played by different forms of proprioceptive feedback in the functional deficit following surgical reinnervation of the main cat plantar flexor muscles will be studied. Using acute and chronic experiments in conjunction with biomechanical modeling, the mechanisms underlying both short term compensation and longer term adaptation will be elucidated. Using intense treadmill ramp training during the recovery period, the preservation of normal reflexes will be studied. This PPG brings together a team of established scientists from diverse backgrounds, with a common goal to continue to strengthen the science base underlying clinical rehabilitation.

该建议是针对由三个项目和三个核心组成的计划项目赠款的。它的总体目标是评估当这种相互作用破坏时，脊柱回路与肌肉骨骼系统之间关系的自适应变化的局限性。在每个项目中，将使用外围神经的横向修复和手术修复模型系统中研究这种中断。在项目I（英语）中，将在大鼠坐骨神经横断后研究自发适应，跑步机训练的影响以及脊柱反射的操作调节对脊柱回路的输出。将确定这些方法与已知的方案相结合的有效性，该方案将确定受伤的外周神经早期再生的早期再生。在项目II（Gregor）中，短期补偿策略在猫中的单个肌肉神经的横切和手术修复后将研究长期补偿性策略在长期自适应变化中的作用。使用动力学，运动学和EMG分析，结缔组织的补偿程度，增强轴突再生的效果以及皮肤感觉系统在这些变化中所起的作用。在项目III（Nichols）中，将研究主要的猫足力屈肌肌肉手术连接后，由不同形式的本体感受反馈发挥的作用。使用急性和慢性实验与生物力学建模结合使用，将阐明短期补偿和长期适应的基础机制。在恢复期间，将使用强烈的跑步机坡道训练，将研究正常反射的保存。该PPG汇集了来自不同背景的成熟科学家团队，其共同的目标是继续加强临床康复的基础科学基础。