Harvard University Center for AIDS Research
哈佛大学艾滋病研究中心
基本信息
- 批准号:8112961
- 负责人:
- 金额:$ 13.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-08-16 至 2012-08-15
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This application proposes continued funding of the Harvard University Center for AIDS Research (HU CFAR). HU CFAR represents each of the Harvard affiliated schools and hospitals, including Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, Children's Hospital Boston, the Immune Disease Institute, Massachusetts General Hospital, Brigham & Women's Hospital, Lemuel Shattuck Hospital, and the
New England Primate Research Center. HU CFAR's goals are: 1) to consolidate and expand existing collaborations among the diverse and highly successful HU-affiliated HIV/AIDS researchers, 2) to promote new interactions and innovative research initiatives capable of more effectively addressing key AIDS research questions and 3) to attract and support the next generation of young scientists into HIV research.
HU CFAR builds collaborations and provides infrastructure support to coordinate and address emerging research opportunities in basic, clinical, behavioral, and translational AIDS activities. Research emphasis among investigators includes studies of molecular virology, pathogenesis, host immune responses, epidemiology, treatment, vaccines and prevention. CFAR funding will provide administrative resources to address the most significant scientific questions in AIDS in six identified Scientific Programs: Behavioral and
Social Sciences, Clinical Epidemiology and Outcomes Research, International, Pathogenesis, Therapeutics, and Vaccines. Five core facilities have also been identified for continued HU CFAR support: Clinical, Molecular Virology/Genomics, Immunology, Biostatistics, and Small Animal Containment. In addition, the Administrative Core will provide strategic planning and fiscal oversight; the Developmental Core will support innovative pilot projects related to the goals of the scientific programs.
HU CFAR will continue to expand, promote, and facilitate collaborative, multidisciplinary activities in AIDS research among CFAR members as the Harvard University model for collaborative inter-institutional interactions. Future planned activities include the development of junior investigators, expansion of the Behavioral and Social Sciences Program, development of the Molecular Virology/Genomics Core facilities,
expansion of access to international clinical specimens, expansion of international research and educational activities, community outreach activities and further collaborations with other CFARs.
本申请建议继续资助哈佛大学艾滋病研究中心(HU CFAR)。HU CFAR代表每个哈佛附属学校和医院,包括达纳法伯癌症研究所,贝丝以色列女执事医疗中心,波士顿儿童医院,免疫疾病研究所,马萨诸塞州总医院,布里格姆妇女医院,Lemuel Shattuck医院和
新英格兰灵长类研究中心。HU CFAR的目标是:1)巩固和扩大现有的合作之间的多样性和非常成功的大学附属艾滋病毒/艾滋病研究人员,2)促进新的互动和创新的研究举措,能够更有效地解决关键的艾滋病研究问题和3)吸引和支持下一代的年轻科学家进入艾滋病毒研究。
HU CFAR建立合作并提供基础设施支持,以协调和解决基础,临床,行为和转化艾滋病活动中出现的研究机会。研究人员的研究重点包括分子病毒学、发病机理、宿主免疫反应、流行病学、治疗、疫苗和预防。CFAR资金将提供行政资源,以解决六个确定的科学计划中最重要的艾滋病科学问题:
社会科学,临床流行病学和成果研究,国际,发病机制,治疗和疫苗。五个核心设施也被确定为继续HU CFAR支持:临床,分子病毒学/基因组学,免疫学,生物统计学和小动物遏制。此外,行政核心将提供战略规划和财政监督;发展核心将支持与科学计划目标有关的创新试点项目。
HU CFAR将继续扩大,促进和促进CFAR成员之间的艾滋病研究合作,多学科活动,作为哈佛大学合作机构间互动的模式。未来计划的活动包括发展初级研究人员,扩大行为和社会科学计划,发展分子病毒学/基因组学核心设施,
扩大国际临床标本的获取,扩大国际研究和教育活动,社区外展活动以及与其他CFAR的进一步合作。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Bruce D Walker其他文献
Immunopathogenesis and immunotherapy in AIDS virus infections
艾滋病病毒感染的免疫发病机制和免疫治疗
- DOI:
10.1038/nm0703-861 - 发表时间:
2003-07-01 - 期刊:
- 影响因子:50.000
- 作者:
Norman L Letvin;Bruce D Walker - 通讯作者:
Bruce D Walker
Targeting the Hedgehog pathway iD therapy-resistant BCR-ABL1 positive leukemia with ponatinib
使用 ponatinib 靶向 Hedgehog 通路 iD 治疗耐药的 BCR-ABL1 阳性白血病
- DOI:
- 发表时间:
2012 - 期刊:
- 影响因子:0
- 作者:
Philip Mwimanzi;Tristan J Markle,Eric Martin;Yoko Ogata;Xiaomei TKuang;Michiyo Tokunaga;MacdonaldMahiti;Florencia Pereyra;ToshiyukiMiura;Bruce D Walker;Zabrina L Brumme,Mark A Brockman and *Takamasa Ueno;Katagiri S - 通讯作者:
Katagiri S
Early virological suppression despite high frequency NNRTI resistance following perinatal prophylaxis in HIV-infected African infants
- DOI:
10.1186/1742-4690-5-s1-o27 - 发表时间:
2008-04-09 - 期刊:
- 影响因子:3.900
- 作者:
Andrew Prendergast;Wendy Mphatswe;Gareth Tudor-Williams;Natasha Blanckenberg;Ayanda Cengimbo;Prakash Jeena;Mpho Rakgotho;Visva Pillay;Christina Thobakgale;Sharon Reddy;Zenele Mncube;Mary Vanderstok;Noel McCarthy;Krista Dong;Hoosen Coovadia;Lynn Morris;Bruce D Walker;Philip Goulder - 通讯作者:
Philip Goulder
Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members
HIV 控制者及其家庭成员中 ccr5 转录下调
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:7.7
- 作者:
E. Gonzalo;Patrick B Rapuano;Uchenna T Ikediobi;Rebecca Leibowitz;S. Mehta;Ayse K Coskun;J Zachary Porterfield;Teagan D Lampkin;Vincent C. Marconi;D. Rimland;Bruce D Walker;S. Deeks;Richard E Sutton - 通讯作者:
Richard E Sutton
Programming CMV for vaccine vector design
为疫苗载体设计编程 CMV
- DOI:
10.1038/nbt.2688 - 发表时间:
2013-09-10 - 期刊:
- 影响因子:41.700
- 作者:
Srinika Ranasinghe;Bruce D Walker - 通讯作者:
Bruce D Walker
Bruce D Walker的其他文献
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{{ truncateString('Bruce D Walker', 18)}}的其他基金
Understanding and Reversing T Cell Dysfunction to Control and Eliminate Persistent HIV Reservoirs
了解和逆转 T 细胞功能障碍以控制和消除持续的 HIV 病毒库
- 批准号:
10308059 - 财政年份:2019
- 资助金额:
$ 13.4万 - 项目类别:
Understanding and Reversing T Cell Dysfunction to Control and Eliminate Persistent HIV Reservoirs
了解和逆转 T 细胞功能障碍以控制和消除持续的 HIV 病毒库
- 批准号:
10523539 - 财政年份:2019
- 资助金额:
$ 13.4万 - 项目类别:
Understanding and Reversing T Cell Dysfunction to Control and Eliminate Persistent HIV Reservoirs
了解和逆转 T 细胞功能障碍以控制和消除持续的 HIV 病毒库
- 批准号:
9893507 - 财政年份:2019
- 资助金额:
$ 13.4万 - 项目类别:
PD-1 expression and HIV specific T cell dysfunction
PD-1 表达和 HIV 特异性 T 细胞功能障碍
- 批准号:
8318852 - 财政年份:2011
- 资助金额:
$ 13.4万 - 项目类别:
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