Administrative Core for the Dietary Biomarkers Development Center at Harvard University
哈佛大学膳食生物标志物开发中心的行政核心
基本信息
- 批准号:10461132
- 负责人:
- 金额:$ 23.04万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-16 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:AchievementAmerican dietAreaBioinformaticsBiological AssayBiological MarkersBiotechnologyBudgetsCarbohydratesCollectionCommittee MembersCommunicationCommunitiesDataData AnalysesData Coordinating CenterDatabasesDietDietary AssessmentDietary InterventionDietary intakeEatingEnergy IntakeEnsureEnvironmentEvaluationExpenditureFollow-Up StudiesFoodGoalsHealth ProfessionalHourIndividualInfrastructureInstitutionInstitutional Review BoardsIntakeInterdisciplinary StudyInterventionIntervention TrialLeadLeadershipMeasurementMeasuresMedicalNational Institute of Diabetes and Digestive and Kidney DiseasesNitrogenNurses&apos Health StudyNutrientNutritional BiochemistryNutritional StudyObesityObservational StudyPatient RecruitmentsPatient Self-ReportPlayPopulation SciencesPostdoctoral FellowPotassiumProgress ReportsProspective cohort studyProteinsPublic Health SchoolsQuality ControlRandomized Clinical TrialsRecoveryResearchResearch DesignResearch PersonnelResourcesRoleScheduleScienceSourceTechniquesTimeTravelUnited States Department of AgricultureUnited States National Institutes of HealthUniversitiesUpdateWorkbioinformatics toolbiomarker developmentcatalystdata sharingdata submissiondietarydoubly-labeled waterfeedinggraduate studenthuman subjectimprovedinnovationmeetingsmetabolomicsmultidisciplinarynovelnovel markernutritionprogramsprotein intaketechnology developmenttraining opportunityurinaryweb site
项目摘要
PROJECT ABSTRACT/SUMMARY – ADMINISTRATIVE CORE
Traditionally, nutrition research has relied heavily on self-reported measures of dietary intake that are often
prone to measurement error. To date, only a few recovery biomarkers of nutrient intake have been established,
including doubly labeled water for estimating energy intake, 24-hour urinary nitrogen for estimating protein
intake, and 24-hour urinary potassium as a biomarker of potassium intake. This highlights the urgent need to
identify further objective and robust biomarkers of food intakes. Recent advances in high-throughput -omics
technologies and the development of novel bioinformatic tools now enable the unbiased discovery of novel
biomarkers that are sensitive and specific to intakes of foods and food groups. The overall objective of the
Dietary Biomarker Development Center (DBDC) at Harvard University is to identify and validate dietary
biomarkers of important protein and carbohydrate food sources in the US diet by using the state-of-the-art
metabolomic techniques and through a combination of well-controlled dietary intervention trials and
observational studies. Our objective is to establish an Administrative Core will play scientific and
administrative leadership roles by integrating the Intervention Core, Data Analysis Core, Metabolomics Core,
and the Biomarkers Project to improve efficiency, enhance innovation, and extend the breadth and depth of the
science within the DBDC at Harvard and across the DBDC’s and the Data Coordinating Center (DCC). The
Core will be led by Dr. Frank Hu, with co-leadership provided by Dr. Clary Clish. Additional key leadership will
be provided by Executive Committee (EC) members, including the Core PIs and Directors and the Project
Director, Dr. Shilpa Bhupathiraju. The DBDC at Harvard Center brings together investigators of diverse
backgrounds and expertise to identify novel biomarkers of several important carbohydrate and protein sources
in the US diet. The expertise in our research team is wide-ranging, covering dietary assessment, population
science, nutritional biochemistry, bioinformatics, and biotechnologies. The stimulating intellectual environment
in the Longwood/Harvard Medical Area is highly conducive for carrying out this research. The Center will take
full advantage of institutional commitment and resources provided by HSPH and other participating institutions,
as well as those provided by the broader Harvard community, such as Harvard Catalyst and the Harvard
Nutrition and Obesity Research Center. The infrastructure for the Administrative Core will provide a strong and
visionary leadership role in science, administration, and dissemination for the DBDC at Harvard University.
项目摘要/摘要--行政核心
传统上,营养研究在很大程度上依赖于自我报告的饮食摄入量指标,这些指标通常
容易出现测量误差。到目前为止,只建立了几个营养摄入量的恢复生物标志物,
包括用于估计能量摄入量的双标记水,用于估计蛋白质的24小时尿氮
摄入量,24小时尿钾作为钾摄入量的生物标志物。这突显了迫切需要
进一步确定食物摄入量的客观和可靠的生物标志物。高通量组学研究进展
现在,技术和新型生物信息学工具的发展使人们能够公正地发现新的
对食物摄入量和食物类别敏感和特异的生物标记物。《公约》的总体目标
哈佛大学膳食生物标记物开发中心(DBDC)将识别和验证膳食
利用最新技术对美国饮食中重要的蛋白质和碳水化合物食物来源的生物标志物
代谢组学技术,并通过良好控制的饮食干预试验和
观察性研究。我们的目标是建立一个行政核心,将发挥科学和
通过整合干预核心、数据分析核心、代谢组学核心、
和生物标记物项目,以提高效率,增强创新,并扩大
哈佛大学DBDC内部以及DBDC和数据协调中心(DCC)之间的科学。这个
CORE将由Frank Hu博士领导,由Clary Clish博士提供联合领导。其他关键领导层将
由执行委员会(EC)成员提供,包括核心绩效指标和主任以及项目
主任,希尔帕·布帕蒂拉朱博士。哈佛中心的DBDC汇集了来自不同领域的研究人员
识别几种重要碳水化合物和蛋白质来源的新生物标志物的背景和专业知识
在美国的饮食中。我们研究团队的专业知识范围很广,包括饮食评估、人口
科学、营养生物化学、生物信息学和生物技术。激动人心的智力环境
在朗伍德/哈佛医学区的研究非常有利于开展这项研究。该中心将承担
充分利用卫生与公众服务部和其他参与机构提供的机构承诺和资源,
以及由更广泛的哈佛社区提供的,如哈佛催化剂和哈佛大学
营养与肥胖研究中心。行政核心的基础设施将提供强大的
哈佛大学DBDC在科学、管理和传播方面具有远见卓识的领导作用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Frank B Hu其他文献
Popular weight-loss diets: from evidence to practice
流行的减肥饮食:从证据到实践
- DOI:
10.1038/ncpcardio0726 - 发表时间:
2007-01-01 - 期刊:
- 影响因子:44.200
- 作者:
Vasanti S Malik;Frank B Hu - 通讯作者:
Frank B Hu
Three decades of the Mediterranean diet pyramid: A narrative review of its history, evolution, and advances
- DOI:
10.1016/j.ajcnut.2025.04.036 - 发表时间:
2025-07-01 - 期刊:
- 影响因子:6.900
- 作者:
Frank B Hu;Greg Drescher;Antonia Trichopoulou;Walter C Willett;Miguel A Martínez-González - 通讯作者:
Miguel A Martínez-González
Food additive emulsifiers: a new risk factor for type 2 diabetes?
食品添加剂乳化剂:2型糖尿病的新危险因素?
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Mengxi Du;Frank B Hu - 通讯作者:
Frank B Hu
Title page, program participants, and TOC
- DOI:
10.3945/ajcn/100.6.1607s - 发表时间:
2014-12-01 - 期刊:
- 影响因子:
- 作者:
An Pan;Frank B Hu - 通讯作者:
Frank B Hu
Dietary patterns, serum metabolites, and risk of cardiovascular disease in United States Hispanic/Latino adults: a prospective analysis of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
- DOI:
10.1016/j.ajcnut.2025.05.008 - 发表时间:
2025-07-01 - 期刊:
- 影响因子:6.900
- 作者:
Hongbo Yang;Yi Wang;Kai Luo;Yasmin Mossavar-Rahmani;Christina Cordero;Robert J Ostfeld;Claudia Martinez;Luis Maldonado;Amber Pirzada;Martha Daviglus;Bing Yu;Frank B Hu;Robert C Kaplan;Qibin Qi - 通讯作者:
Qibin Qi
Frank B Hu的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Frank B Hu', 18)}}的其他基金
Lifestyle Interventions, metabolites, microbiome, and diabetes risk
生活方式干预、代谢物、微生物组和糖尿病风险
- 批准号:
10557795 - 财政年份:2021
- 资助金额:
$ 23.04万 - 项目类别:
Administrative Core for the Dietary Biomarkers Development Center at Harvard University
哈佛大学膳食生物标志物开发中心的行政核心
- 批准号:
10649586 - 财政年份:2021
- 资助金额:
$ 23.04万 - 项目类别:
Lifestyle Interventions, metabolites, microbiome, and diabetes risk
生活方式干预、代谢物、微生物组和糖尿病风险
- 批准号:
10370323 - 财政年份:2021
- 资助金额:
$ 23.04万 - 项目类别:
Administrative Core for the Dietary Biomarkers Development Center at Harvard University
哈佛大学膳食生物标志物开发中心的行政核心
- 批准号:
10289794 - 财政年份:2021
- 资助金额:
$ 23.04万 - 项目类别:
Dietary Interventions, Metabolites, and Risk of Type 2 Diabetes
饮食干预、代谢物和 2 型糖尿病的风险
- 批准号:
8918612 - 财政年份:2014
- 资助金额:
$ 23.04万 - 项目类别:
Dietary Interventions, Metabolites, and Risk of Type 2 Diabetes
饮食干预、代谢物和 2 型糖尿病的风险
- 批准号:
8760615 - 财政年份:2014
- 资助金额:
$ 23.04万 - 项目类别:
Mediterranean diet, Metabolites, and cardiovascular Disease
地中海饮食、代谢物和心血管疾病
- 批准号:
9090169 - 财政年份:2013
- 资助金额:
$ 23.04万 - 项目类别:
Mediterranean diet, Metabolites, and Cardiovascular Disease
地中海饮食、代谢物和心血管疾病
- 批准号:
10551729 - 财政年份:2013
- 资助金额:
$ 23.04万 - 项目类别:
Mediterranean diet, Metabolites, and cardiovascular Disease
地中海饮食、代谢物和心血管疾病
- 批准号:
8482202 - 财政年份:2013
- 资助金额:
$ 23.04万 - 项目类别:
Mediterranean diet, Metabolites, and cardiovascular Disease
地中海饮食、代谢物和心血管疾病
- 批准号:
9388404 - 财政年份:2013
- 资助金额:
$ 23.04万 - 项目类别:
相似海外基金
GLUCOSE RESPONSE TO FOODS IN THE MEXICAN-AMERICAN DIET
墨西哥裔美国人饮食中食物的葡萄糖反应
- 批准号:
3788324 - 财政年份:
- 资助金额:
$ 23.04万 - 项目类别:
GLUCOSE RESPONSE TO FOODS IN THE MEXICAN-AMERICAN DIET
墨西哥裔美国人饮食中食物的葡萄糖反应
- 批准号:
3887690 - 财政年份:
- 资助金额:
$ 23.04万 - 项目类别: