Administrative Core for the Dietary Biomarkers Development Center at Harvard University

哈佛大学膳食生物标志物开发中心的行政核心

• 批准号: 10461132
• 负责人: Frank B Hu
• 金额: $ 23.04万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-16 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10461132
• 关键词: Achievement; American diet; Area; Bioinformatics; Biological Assay; Biological Markers; Biotechnology; Budgets; Carbohydrates; Collection; Committee Members; Communication; Communities; Data; Data Analyses; Data Coordinating Center; Databases; Diet; Dietary Assessment; Dietary Intervention; Dietary intake; Eating; Energy Intake; Ensure; Environment; Evaluation; Expenditure; Follow-Up Studies; Food; Goals; Health Professional; Hour; Individual; Infrastructure; Institution; Institutional Review Boards; Intake; Interdisciplinary Study; Intervention; Intervention Trial; Lead; Leadership; Measurement; Measures; Medical; National Institute of Diabetes and Digestive and Kidney Diseases; Nitrogen; Nurses' Health Study; Nutrient; Nutritional Biochemistry; Nutritional Study; Obesity; Observational Study; Patient Recruitments; Patient Self-Report; Play; Population Sciences; Postdoctoral Fellow; Potassium; Progress Reports; Prospective cohort study; Proteins; Public Health Schools; Quality Control; Randomized Clinical Trials; Recovery; Research; Research Design; Research Personnel; Resources; Role; Schedule; Science; Source; Techniques; Time; Travel; United States Department of Agriculture; United States National Institutes of Health; Universities; Update; Work; bioinformatics tool; biomarker development; catalyst; data sharing; data submission; dietary; doubly-labeled water; feeding; graduate student; human subject; improved; innovation; meetings; metabolomics; multidisciplinary; novel; novel marker; nutrition; programs; protein intake; technology development; training opportunity; urinary; web site

PROJECT ABSTRACT/SUMMARY – ADMINISTRATIVE CORE Traditionally, nutrition research has relied heavily on self-reported measures of dietary intake that are often prone to measurement error. To date, only a few recovery biomarkers of nutrient intake have been established, including doubly labeled water for estimating energy intake, 24-hour urinary nitrogen for estimating protein intake, and 24-hour urinary potassium as a biomarker of potassium intake. This highlights the urgent need to identify further objective and robust biomarkers of food intakes. Recent advances in high-throughput -omics technologies and the development of novel bioinformatic tools now enable the unbiased discovery of novel biomarkers that are sensitive and specific to intakes of foods and food groups. The overall objective of the Dietary Biomarker Development Center (DBDC) at Harvard University is to identify and validate dietary biomarkers of important protein and carbohydrate food sources in the US diet by using the state-of-the-art metabolomic techniques and through a combination of well-controlled dietary intervention trials and observational studies. Our objective is to establish an Administrative Core will play scientific and administrative leadership roles by integrating the Intervention Core, Data Analysis Core, Metabolomics Core, and the Biomarkers Project to improve efficiency, enhance innovation, and extend the breadth and depth of the science within the DBDC at Harvard and across the DBDC’s and the Data Coordinating Center (DCC). The Core will be led by Dr. Frank Hu, with co-leadership provided by Dr. Clary Clish. Additional key leadership will be provided by Executive Committee (EC) members, including the Core PIs and Directors and the Project Director, Dr. Shilpa Bhupathiraju. The DBDC at Harvard Center brings together investigators of diverse backgrounds and expertise to identify novel biomarkers of several important carbohydrate and protein sources in the US diet. The expertise in our research team is wide-ranging, covering dietary assessment, population science, nutritional biochemistry, bioinformatics, and biotechnologies. The stimulating intellectual environment in the Longwood/Harvard Medical Area is highly conducive for carrying out this research. The Center will take full advantage of institutional commitment and resources provided by HSPH and other participating institutions, as well as those provided by the broader Harvard community, such as Harvard Catalyst and the Harvard Nutrition and Obesity Research Center. The infrastructure for the Administrative Core will provide a strong and visionary leadership role in science, administration, and dissemination for the DBDC at Harvard University.

项目摘要/摘要-行政核心 传统上，营养研究严重依赖于自我报告的饮食摄入量，这些摄入量通常是 容易产生测量误差。到目前为止，只有少数营养摄入的恢复生物标志物已经建立， 包括用于估计能量摄入的双标记水、用于估计蛋白质的24小时尿氮 24小时尿钾作为钾摄入量的生物标志物。这突出表明迫切需要 确定食物摄入量的进一步客观和可靠的生物标志物。高通量组学研究进展 技术和新的生物信息学工具的发展，现在使公正的发现新的 这些生物标志物对食物和食物组的摄入量敏感和特异。的总体目标 哈佛大学的饮食生物标志物开发中心（DBDC）是为了识别和验证饮食中的生物标志物。 美国饮食中重要蛋白质和碳水化合物食物来源的生物标志物 代谢组学技术，并通过良好控制的饮食干预试验和 观察性研究我们的目标是建立一个行政核心将发挥科学和 通过整合干预核心，数据分析核心，代谢组学核心， 和生物标志物项目，以提高效率，加强创新，并扩大的广度和深度， 在哈佛的DBDC内以及在DBDC和数据协调中心（DCC）之间进行科学研究。的 核心将由Frank Hu博士领导，由Clary Clish博士共同领导。其他主要领导人将 由执行委员会（EC）成员提供，包括核心PI和董事以及项目 主任，希尔帕·布帕蒂拉朱博士。哈佛中心的DBDC汇集了来自不同领域的研究人员， 背景和专业知识，以确定几个重要的碳水化合物和蛋白质来源的新的生物标志物 在美国的饮食。我们研究团队的专业知识范围广泛，涵盖膳食评估、人口 科学、营养生物化学、生物信息学和生物技术。刺激的智力环境 在朗伍德/哈佛医学区的研究非常有利于开展这项研究。该中心将采取 充分利用卫生部和其他参与机构提供的机构承诺和资源， 以及更广泛的哈佛社区提供的服务，如哈佛催化剂和哈佛 营养与肥胖研究中心。行政核心的基础设施将提供强大的 在哈佛大学DBDC的科学、管理和传播方面发挥有远见的领导作用。