Administrative Core for the Dietary Biomarkers Development Center at Harvard University

哈佛大学膳食生物标志物开发中心的行政核心

• 批准号: 10649586
• 负责人: Frank B Hu
• 金额: $ 18.77万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-16 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10649586
• 关键词: Achievement; American diet; Area; Bioinformatics; Biological Assay; Biological Markers; Biotechnology; Budgets; Carbohydrates; Collection; Committee Members; Communication; Communities; Data; Data Analyses; Data Coordinating Center; Databases; Development; Diet; Dietary Assessment; Dietary Intervention; Dietary intake; Eating; Energy Intake; Ensure; Environment; Evaluation; Expenditure; Follow-Up Studies; Food; Goals; Health Professional; Hour; Individual; Infrastructure; Institution; Institutional Review Boards; Intake; Interdisciplinary Study; Intervention; Intervention Trial; Lead; Leadership; Measurement; Measures; Medical; National Institute of Diabetes and Digestive and Kidney Diseases; Nitrogen; Nurses' Health Study; Nutrient; Nutritional Biochemistry; Nutritional Study; Obesity; Observational Study; Patient Recruitments; Patient Self-Report; Play; Population Sciences; Postdoctoral Fellow; Potassium; Progress Reports; Prospective, cohort study; Proteins; Public Health Schools; Quality Control; Recovery; Research; Research Design; Research Personnel; Resources; Role; Schedule; Science; Source; Techniques; Technology; Travel; United States Department of Agriculture; United States National Institutes of Health; Universities; Update; Work; bioinformatics tool; biomarker development; biomarker validation; catalyst; data sharing; data submission; dietary; doubly-labeled water; feeding; graduate student; human subject; improved; innovation; meetings; metabolomics; multidisciplinary; novel; novel marker; nutrition; programs; protein intake; randomized, clinical trials; training opportunity; urinary; web site

PROJECT ABSTRACT/SUMMARY – ADMINISTRATIVE CORE Traditionally, nutrition research has relied heavily on self-reported measures of dietary intake that are often prone to measurement error. To date, only a few recovery biomarkers of nutrient intake have been established, including doubly labeled water for estimating energy intake, 24-hour urinary nitrogen for estimating protein intake, and 24-hour urinary potassium as a biomarker of potassium intake. This highlights the urgent need to identify further objective and robust biomarkers of food intakes. Recent advances in high-throughput -omics technologies and the development of novel bioinformatic tools now enable the unbiased discovery of novel biomarkers that are sensitive and specific to intakes of foods and food groups. The overall objective of the Dietary Biomarker Development Center (DBDC) at Harvard University is to identify and validate dietary biomarkers of important protein and carbohydrate food sources in the US diet by using the state-of-the-art metabolomic techniques and through a combination of well-controlled dietary intervention trials and observational studies. Our objective is to establish an Administrative Core will play scientific and administrative leadership roles by integrating the Intervention Core, Data Analysis Core, Metabolomics Core, and the Biomarkers Project to improve efficiency, enhance innovation, and extend the breadth and depth of the science within the DBDC at Harvard and across the DBDC’s and the Data Coordinating Center (DCC). The Core will be led by Dr. Frank Hu, with co-leadership provided by Dr. Clary Clish. Additional key leadership will be provided by Executive Committee (EC) members, including the Core PIs and Directors and the Project Director, Dr. Shilpa Bhupathiraju. The DBDC at Harvard Center brings together investigators of diverse backgrounds and expertise to identify novel biomarkers of several important carbohydrate and protein sources in the US diet. The expertise in our research team is wide-ranging, covering dietary assessment, population science, nutritional biochemistry, bioinformatics, and biotechnologies. The stimulating intellectual environment in the Longwood/Harvard Medical Area is highly conducive for carrying out this research. The Center will take full advantage of institutional commitment and resources provided by HSPH and other participating institutions, as well as those provided by the broader Harvard community, such as Harvard Catalyst and the Harvard Nutrition and Obesity Research Center. The infrastructure for the Administrative Core will provide a strong and visionary leadership role in science, administration, and dissemination for the DBDC at Harvard University.

项目摘要/摘要--行政核心 传统上，营养研究在很大程度上依赖于自我报告的饮食摄入量指标，这些指标通常 容易出现测量误差。到目前为止，只建立了几个营养摄入量的恢复生物标志物， 包括用于估计能量摄入量的双标记水，用于估计蛋白质的24小时尿氮 摄入量，24小时尿钾作为钾摄入量的生物标志物。这突显了迫切需要 进一步确定食物摄入量的客观和可靠的生物标志物。高通量组学研究进展 现在，技术和新型生物信息学工具的发展使人们能够公正地发现新的 对食物摄入量和食物类别敏感和特异的生物标记物。《公约》的总体目标 哈佛大学膳食生物标记物开发中心(DBDC)将识别和验证膳食 利用最新技术对美国饮食中重要的蛋白质和碳水化合物食物来源的生物标志物 代谢组学技术，并通过良好控制的饮食干预试验和 观察性研究。我们的目标是建立一个行政核心，将发挥科学和 通过整合干预核心、数据分析核心、代谢组学核心、 和生物标记物项目，以提高效率，增强创新，并扩大 哈佛大学DBDC内部以及DBDC和数据协调中心(DCC)之间的科学。这个 CORE将由Frank Hu博士领导，由Clary Clish博士提供联合领导。其他关键领导层将 由执行委员会(EC)成员提供，包括核心绩效指标和主任以及项目 主任，希尔帕·布帕蒂拉朱博士。哈佛中心的DBDC汇集了来自不同领域的研究人员 识别几种重要碳水化合物和蛋白质来源的新生物标志物的背景和专业知识 在美国的饮食中。我们研究团队的专业知识范围很广，包括饮食评估、人口 科学、营养生物化学、生物信息学和生物技术。激动人心的智力环境 在朗伍德/哈佛医学区的研究非常有利于开展这项研究。该中心将承担 充分利用卫生与公众服务部和其他参与机构提供的机构承诺和资源， 以及由更广泛的哈佛社区提供的，如哈佛催化剂和哈佛大学 营养与肥胖研究中心。行政核心的基础设施将提供强大的 哈佛大学DBDC在科学、管理和传播方面具有远见卓识的领导作用。