Administrative Core for the Dietary Biomarkers Development Center at Harvard University

哈佛大学膳食生物标志物开发中心的行政核心

基本信息

  • 批准号:
    10649586
  • 负责人:
  • 金额:
    $ 18.77万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-08-16 至 2026-06-30
  • 项目状态:
    未结题

项目摘要

PROJECT ABSTRACT/SUMMARY – ADMINISTRATIVE CORE Traditionally, nutrition research has relied heavily on self-reported measures of dietary intake that are often prone to measurement error. To date, only a few recovery biomarkers of nutrient intake have been established, including doubly labeled water for estimating energy intake, 24-hour urinary nitrogen for estimating protein intake, and 24-hour urinary potassium as a biomarker of potassium intake. This highlights the urgent need to identify further objective and robust biomarkers of food intakes. Recent advances in high-throughput -omics technologies and the development of novel bioinformatic tools now enable the unbiased discovery of novel biomarkers that are sensitive and specific to intakes of foods and food groups. The overall objective of the Dietary Biomarker Development Center (DBDC) at Harvard University is to identify and validate dietary biomarkers of important protein and carbohydrate food sources in the US diet by using the state-of-the-art metabolomic techniques and through a combination of well-controlled dietary intervention trials and observational studies. Our objective is to establish an Administrative Core will play scientific and administrative leadership roles by integrating the Intervention Core, Data Analysis Core, Metabolomics Core, and the Biomarkers Project to improve efficiency, enhance innovation, and extend the breadth and depth of the science within the DBDC at Harvard and across the DBDC’s and the Data Coordinating Center (DCC). The Core will be led by Dr. Frank Hu, with co-leadership provided by Dr. Clary Clish. Additional key leadership will be provided by Executive Committee (EC) members, including the Core PIs and Directors and the Project Director, Dr. Shilpa Bhupathiraju. The DBDC at Harvard Center brings together investigators of diverse backgrounds and expertise to identify novel biomarkers of several important carbohydrate and protein sources in the US diet. The expertise in our research team is wide-ranging, covering dietary assessment, population science, nutritional biochemistry, bioinformatics, and biotechnologies. The stimulating intellectual environment in the Longwood/Harvard Medical Area is highly conducive for carrying out this research. The Center will take full advantage of institutional commitment and resources provided by HSPH and other participating institutions, as well as those provided by the broader Harvard community, such as Harvard Catalyst and the Harvard Nutrition and Obesity Research Center. The infrastructure for the Administrative Core will provide a strong and visionary leadership role in science, administration, and dissemination for the DBDC at Harvard University.
项目摘要/摘要-行政核心

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Frank B Hu其他文献

Popular weight-loss diets: from evidence to practice
流行的减肥饮食:从证据到实践
  • DOI:
    10.1038/ncpcardio0726
  • 发表时间:
    2007-01-01
  • 期刊:
  • 影响因子:
    44.200
  • 作者:
    Vasanti S Malik;Frank B Hu
  • 通讯作者:
    Frank B Hu
Three decades of the Mediterranean diet pyramid: A narrative review of its history, evolution, and advances
  • DOI:
    10.1016/j.ajcnut.2025.04.036
  • 发表时间:
    2025-07-01
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Frank B Hu;Greg Drescher;Antonia Trichopoulou;Walter C Willett;Miguel A Martínez-González
  • 通讯作者:
    Miguel A Martínez-González
Food additive emulsifiers: a new risk factor for type 2 diabetes?
食品添加剂乳化剂:2型糖尿病的新危险因素?
Title page, program participants, and TOC
  • DOI:
    10.3945/ajcn/100.6.1607s
  • 发表时间:
    2014-12-01
  • 期刊:
  • 影响因子:
  • 作者:
    An Pan;Frank B Hu
  • 通讯作者:
    Frank B Hu
Dietary patterns, serum metabolites, and risk of cardiovascular disease in United States Hispanic/Latino adults: a prospective analysis of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
  • DOI:
    10.1016/j.ajcnut.2025.05.008
  • 发表时间:
    2025-07-01
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Hongbo Yang;Yi Wang;Kai Luo;Yasmin Mossavar-Rahmani;Christina Cordero;Robert J Ostfeld;Claudia Martinez;Luis Maldonado;Amber Pirzada;Martha Daviglus;Bing Yu;Frank B Hu;Robert C Kaplan;Qibin Qi
  • 通讯作者:
    Qibin Qi

Frank B Hu的其他文献

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{{ truncateString('Frank B Hu', 18)}}的其他基金

Lifestyle Interventions, metabolites, microbiome, and diabetes risk
生活方式干预、代谢物、微生物组和糖尿病风险
  • 批准号:
    10557795
  • 财政年份:
    2021
  • 资助金额:
    $ 18.77万
  • 项目类别:
Administrative Core for the Dietary Biomarkers Development Center at Harvard University
哈佛大学膳食生物标志物开发中心的行政核心
  • 批准号:
    10461132
  • 财政年份:
    2021
  • 资助金额:
    $ 18.77万
  • 项目类别:
Lifestyle Interventions, metabolites, microbiome, and diabetes risk
生活方式干预、代谢物、微生物组和糖尿病风险
  • 批准号:
    10370323
  • 财政年份:
    2021
  • 资助金额:
    $ 18.77万
  • 项目类别:
Administrative Core for the Dietary Biomarkers Development Center at Harvard University
哈佛大学膳食生物标志物开发中心的行政核心
  • 批准号:
    10289794
  • 财政年份:
    2021
  • 资助金额:
    $ 18.77万
  • 项目类别:
Dietary Interventions, Metabolites, and Risk of Type 2 Diabetes
饮食干预、代谢物和 2 型糖尿病的风险
  • 批准号:
    8918612
  • 财政年份:
    2014
  • 资助金额:
    $ 18.77万
  • 项目类别:
Dietary Interventions, Metabolites, and Risk of Type 2 Diabetes
饮食干预、代谢物和 2 型糖尿病的风险
  • 批准号:
    8760615
  • 财政年份:
    2014
  • 资助金额:
    $ 18.77万
  • 项目类别:
Mediterranean diet, Metabolites, and cardiovascular Disease
地中海饮食、代谢物和心血管疾病
  • 批准号:
    9090169
  • 财政年份:
    2013
  • 资助金额:
    $ 18.77万
  • 项目类别:
Mediterranean diet, Metabolites, and Cardiovascular Disease
地中海饮食、代谢物和心血管疾病
  • 批准号:
    10551729
  • 财政年份:
    2013
  • 资助金额:
    $ 18.77万
  • 项目类别:
Mediterranean diet, Metabolites, and cardiovascular Disease
地中海饮食、代谢物和心血管疾病
  • 批准号:
    8482202
  • 财政年份:
    2013
  • 资助金额:
    $ 18.77万
  • 项目类别:
Mediterranean diet, Metabolites, and cardiovascular Disease
地中海饮食、代谢物和心血管疾病
  • 批准号:
    9388404
  • 财政年份:
    2013
  • 资助金额:
    $ 18.77万
  • 项目类别:

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  • 批准号:
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