Molecular Mechanisms and Genetics of Autoimmunity

描述（申请人提供）：俄克拉荷马州医学研究基金会（OMRF）的“自身免疫的分子机制和遗传学”的COBRE计划已经赞助了14项研究，产生了> 240，000，000种基因型，发表了130篇重要手稿，使多项NIH赠款成为可能，并招募了8名新的教职员工（Susan Kovats博士、Amr Sawaiha医学博士、玛丽贝丝汉弗莱医学博士、Kathy Moser医学博士、Pat Gaffney医学博士、Jonathan Wren医学博士、Courtney Gray-McGuire医学博士和玛尔塔Alarcon-Riquelme医学博士）。总而言之，我们达到了成功的标准。我们的座右铭是通过指导和建立相关的基础设施来实现专业成长。我们的几位年轻科学家做得很好。例如，Swapan K. Nath博士确定ITGAM（又名CD 11b，MAC-1，CR 3）是系统性红斑狼疮的基因，R77 H是其可能的致病多态性。他的重要发现已在多项其他研究中得到证实。Swapan Nath、玛丽贝丝汉弗莱（医学博士、博士）、Amr Sawaiha（医学博士）、Susan Kovats（博士）和Ken考夫曼（博士）分别获得了R 01、R 01和R 03、R21和VA优异奖的资助。随着其对指导我们的COBRE计划的重点已经改变了我们的科学文化走向开放，教师的相互鼓励，无论是高级或初级。这也有助于发展科学事业，并产生杰出的科学成果。为了开始未来五年，我们提出了4个研究项目，一个招募研究和一个试点研究。每一位获得资助的COBRE科学家都有可能成为一名独立的职业，产生关键的见解和实验。作为科学家，他们将得到核酸和数据分析核心的支持，并在行政核心下履行指导和其他职能。此外，招聘的成功将继续与招聘核心，旨在提供辅助支持，以扩大正在进行的OMRF。随着竞争性更新，我们的计划是建立尽可能多的生产性科学事业，尽可能多的优秀教师填充我们的机构，以提高我们在自身免疫方面的科学卓越的国际声誉，并在此过程中产生至关重要的新发现。 公共卫生相关性（由申请人提供）：据估计，自身免疫性疾病困扰着多达50，000，000的同胞。该COBRE计划将研究过程，识别基因，并开发了解这些疾病的基本知识，专注于系统性红斑狼疮，这是一种潜在致命的自身免疫性疾病，主要发生在年轻女性身上，因此新知识将导致新的诊断，诊断和治疗。

DESCRIPTION (provided by applicant): The COBRE Program in the "Molecular Mechanisms and Genetics of Autoimmunity" at the Oklahoma Medical Research Foundation (OMRF) has sponsored 14 studies, generated >240,000,000 genotypes, published 130 important manuscripts, made possible the funding of multiple NIH grants, and has resulted in recruiting of 8 new faculty members (Susan Kovats, PhD, Amr Sawaiha, MD, Mary Beth Humphrey, MD, PhD, Kathy Moser, PhD, Pat Gaffney, MD, Jonathan Wren, PhD, Courtney Gray-McGuire, PhD, and Marta Alarcon-Riquelme, MD, PhD). All in all, we have met the standard for success. Our mantra is professional growth through mentoring and through building relevant infrastructure. Several of our junior scientists have done well. For example, Swapan K. Nath, PhD, identified ITGAM (aka CD11b, MAC-1, CR3) as a gene for systemic lupus erythematosus and R77H as its probable causative polymorphism. His essential findings have been confirmed in multiple other studies. Swapan Nath, Mary Beth Humphrey, MD, PhD, Amr Sawaiha, MD, Susan Kovats, PhD, and Ken Kaufman, PhD have been funded respectively, by an R01, another R01 an R03, an R21, and a VA Merit Award. With its emphasis on mentoring our COBRE Program has changed our scientific culture toward open, mutual encouragement of faculty, whether senior or junior. This has also served to develop careers in science and to produce outstanding scientific results. To begin the coming five years we present 4 research projects, a recruiting study and one pilot study. Each COBRE scientist funded holds the potential promise for an independent career, producing critical insights and experiments. Scientifically, they will be supported by Nucleic Acid and Data Analysis Cores with mentoring and other functions under an Administrative Core. In addition, the recruiting successes will be continued with a Recruiting Core designed to provide adjunct support to the expansion underway at the OMRF. With the competitive renewal, our plan is to build as many productive scientific careers as possible, to populate our institutions with as many exceptional faculty members as possible, to enhance our international reputation for scientific excellence in autoimmunity, and to produce critically important new discoveries in the process. PUBLIC HEALTH RELEVANCE (provided by applicant): Autoimmune diseases are estimated to afflict as many as 50,000,000 of our fellow citizens. This COBRE Program will study process, identify genes, and develop knowledge basic to understanding these disorders, concentrating on systemic lupus erythematosus, a potentially deadly autoimmune disease, found mainly in young women, so that the new knowledge will lead to new diagnostics, prognostics and therapeutics.