Molecular Mechanisms and Genetics of Autoimmunity

描述(由申请人提供)：俄克拉荷马医学研究基金会(OMRF)“自身免疫的分子机制和遗传学”中的Cobre计划已经赞助了14项研究，产生了24,000,000种基因型，发表了130篇重要手稿，使NIH的多笔拨款成为可能，并招募了8名新教师(Susan Kovats，Phd，Amr Sawaha，MD，Mary Beth Humphrey，MD，PhD，Kathy Moser，PhD，Pat Gaffney，MD，Jonathan Wren，PhD，Courtney Gray-McGuire，PhD和Marta Alarcon-Riqume，MD，PhD)。总而言之，我们达到了成功的标准。我们的口号是通过指导和建立相关的基础设施来实现专业成长。我们的几位初级科学家做得很好。例如，Swapan K.Nath博士发现ITGAM(又名CD11b，MAC-1，CR3)是系统性红斑狼疮的一个基因，R77H是其可能的致病基因。他的基本发现已经在其他多项研究中得到证实。斯瓦潘·纳特、玛丽·贝丝·汉弗莱、医学博士、阿姆鲁·萨瓦哈医学博士、苏珊·科瓦茨博士和肯·考夫曼博士分别获得了R01、R01和R03、R21和VA荣誉奖的资助。由于注重指导，我们的科布雷计划改变了我们的科学文化，使之朝着开放、相互鼓励的方向发展，无论是资深还是初级教职员工。这也有助于发展科学事业，产生杰出的科学成果。作为未来五年的开始，我们提出了四个研究项目，一项招聘研究和一项试点研究。科布雷资助的每一位科学家都有可能成为一名独立的职业，产生关键的见解和实验。科学上，它们将得到行政核心下具有指导和其他职能的核酸和数据分析核心的支持。此外，征聘方面的成功将通过一个招聘核心继续下去，该核心旨在为监察员办公室正在进行的扩展提供辅助支持。通过竞争更新，我们的计划是建立尽可能多的富有成效的科学事业，为我们的机构配备尽可能多的杰出教职员工，提高我们在自身免疫领域卓越科学方面的国际声誉，并在此过程中产生至关重要的新发现。 公共卫生相关性(由申请人提供)：据估计，自身免疫性疾病困扰着多达5000万我国公民同胞。这一科布雷计划将研究过程，识别基因，并开发了解这些疾病的基础知识，重点关注系统性红斑狼疮，这是一种主要在年轻女性中发现的潜在致命自身免疫性疾病，因此新知识将导致新的诊断、预后和治疗。

DESCRIPTION (provided by applicant): The COBRE Program in the "Molecular Mechanisms and Genetics of Autoimmunity" at the Oklahoma Medical Research Foundation (OMRF) has sponsored 14 studies, generated >240,000,000 genotypes, published 130 important manuscripts, made possible the funding of multiple NIH grants, and has resulted in recruiting of 8 new faculty members (Susan Kovats, PhD, Amr Sawaiha, MD, Mary Beth Humphrey, MD, PhD, Kathy Moser, PhD, Pat Gaffney, MD, Jonathan Wren, PhD, Courtney Gray-McGuire, PhD, and Marta Alarcon-Riquelme, MD, PhD). All in all, we have met the standard for success. Our mantra is professional growth through mentoring and through building relevant infrastructure. Several of our junior scientists have done well. For example, Swapan K. Nath, PhD, identified ITGAM (aka CD11b, MAC-1, CR3) as a gene for systemic lupus erythematosus and R77H as its probable causative polymorphism. His essential findings have been confirmed in multiple other studies. Swapan Nath, Mary Beth Humphrey, MD, PhD, Amr Sawaiha, MD, Susan Kovats, PhD, and Ken Kaufman, PhD have been funded respectively, by an R01, another R01 an R03, an R21, and a VA Merit Award. With its emphasis on mentoring our COBRE Program has changed our scientific culture toward open, mutual encouragement of faculty, whether senior or junior. This has also served to develop careers in science and to produce outstanding scientific results. To begin the coming five years we present 4 research projects, a recruiting study and one pilot study. Each COBRE scientist funded holds the potential promise for an independent career, producing critical insights and experiments. Scientifically, they will be supported by Nucleic Acid and Data Analysis Cores with mentoring and other functions under an Administrative Core. In addition, the recruiting successes will be continued with a Recruiting Core designed to provide adjunct support to the expansion underway at the OMRF. With the competitive renewal, our plan is to build as many productive scientific careers as possible, to populate our institutions with as many exceptional faculty members as possible, to enhance our international reputation for scientific excellence in autoimmunity, and to produce critically important new discoveries in the process. PUBLIC HEALTH RELEVANCE (provided by applicant): Autoimmune diseases are estimated to afflict as many as 50,000,000 of our fellow citizens. This COBRE Program will study process, identify genes, and develop knowledge basic to understanding these disorders, concentrating on systemic lupus erythematosus, a potentially deadly autoimmune disease, found mainly in young women, so that the new knowledge will lead to new diagnostics, prognostics and therapeutics.