Administrative Core

在过去的十年中，俄克拉荷马州 COBRE GM103456（以前的 RR020143）“分子机制和 自身免疫遗传学”一直是俄克拉荷马州医学研究转型的关键资源 基金会成为一个致力于指导和发展初级研究人员的机构 富有成效的独立科学事业，重点是自身免疫性疾病的遗传学。 通过 11 名初级研究员、16 个试点项目以及不断发展的 3-4 个核心组的支持，该项目 资源提供了基础设施来帮助启动 11 个独立研究职业并支持 随后获得由其他 NIH 机构资助的众多多研究者资助（“项目资助”）。 我们的管理核心将作为 COBRE 的集中管理资源，提供 对研究和试点核心提供行政协助和监督，并充当各研究中心之间的联络人 指导委员会、外部咨询委员会、机构管理部门和 COBRE 调查员。的 继续开展 COBRE 的科学战略目的是支持遗传学和 自身免疫性疾病的基因组学，并开始将 COBRE 研究人员的范围扩大到其他领域 学科包括癌症、心血管疾病和罕见疾病。具体目标 行政核心是 1）协调、整合和财政管理财务独立研究 核心，满足并扩展我们 COBRE 研究人员的科学机会，2) 评估和 管理研究核心和试点项目的有效性，3）实施和扩展多学科 丰富计划，4) 协助处理拨款申请、管理和合规问题。

For the past decade, the Oklahoma COBRE GM103456 (previously RR020143) "Molecular Mechanisms and Genetics of Autoimmunity" has been a pivotal resource in transforming the Oklahoma Medical Research Foundation into an institution committed to the mentoring and development of junior investigators to productive independent scientific careers with an emphasis on the genetics of autoimmune diseases. Through its support of 11 junior investigators, 16 pilot projects, and an evolving set of 3-4 cores, this resource has provided the infrastructure to help launch 11 independent research careers and support the subsequent funding of numerous multi-investigator grants ("program grants") funded by other NIH institutes. Our Administrative Core will serve as a centralized governing resource for the COBRE, provide adminitstrative assistance and oversight to the research and Pilot cores and serve as a liason between the steering committee, external advisory committee, institutional administration and COBRE investigators. The scientific strategic purpose of the continuation of this COBRE is to support research in the genetics and genomics of autoimmune diseases and begin to broaden our scope of COBRE investigators to other disciplines including cancer, cardiovascular diseases and rare disorders. The Specific Aims ofthe Administrative core are to 1) coordinate, integrate and fiscally manage to financial independence research cores, which meet and extend the scientific opportunities of our COBRE Investigators, 2) evaluate and manage the effectiveness of research cores and pilot projects, 3) implement and expand multidisciplinary enrichment programs and, 4) assist with grant applications, management and compliance issues.