Administrative Core

在过去的十年中，俄克拉荷马州科布雷GM103456(以前的RR020143)“分子机制和 《自身免疫遗传学》是转变俄克拉荷马州医学研究的关键资源 基金会成为一家致力于指导和发展初级调查人员的机构 富有成效的独立科学事业，重点研究自身免疫性疾病的遗传学。 通过支持11名初级调查人员、16个试点项目和一套不断演变的3-4个核心，这 资源提供了基础设施，以帮助启动11个独立研究职业，并支持 随后资助了许多由其他NIH研究所资助的多名研究人员资助(“项目资助”)。 我们的行政核心将作为COBRE的集中管理资源，提供 对研究和试验核心的行政协助和监督，并作为 指导委员会、外部咨询委员会、机构行政和科布雷调查员。这个 科布雷延续的科学战略目的是支持遗传学和 自身免疫性疾病的基因组学并开始将我们的Cobre研究人员的范围扩大到其他 这些学科包括癌症、心血管疾病和罕见疾病。《公约》的具体目标 行政管理的核心是1)对财务独立研究进行协调、整合和财务管理 满足并扩展我们Cobre研究人员的科学机会的核心，2)评估和 管理研究核心和试点项目的有效性，3)实施和扩展多学科 丰富计划；4)协助拨款申请、管理和合规问题。

For the past decade, the Oklahoma COBRE GM103456 (previously RR020143) "Molecular Mechanisms and Genetics of Autoimmunity" has been a pivotal resource in transforming the Oklahoma Medical Research Foundation into an institution committed to the mentoring and development of junior investigators to productive independent scientific careers with an emphasis on the genetics of autoimmune diseases. Through its support of 11 junior investigators, 16 pilot projects, and an evolving set of 3-4 cores, this resource has provided the infrastructure to help launch 11 independent research careers and support the subsequent funding of numerous multi-investigator grants ("program grants") funded by other NIH institutes. Our Administrative Core will serve as a centralized governing resource for the COBRE, provide adminitstrative assistance and oversight to the research and Pilot cores and serve as a liason between the steering committee, external advisory committee, institutional administration and COBRE investigators. The scientific strategic purpose of the continuation of this COBRE is to support research in the genetics and genomics of autoimmune diseases and begin to broaden our scope of COBRE investigators to other disciplines including cancer, cardiovascular diseases and rare disorders. The Specific Aims ofthe Administrative core are to 1) coordinate, integrate and fiscally manage to financial independence research cores, which meet and extend the scientific opportunities of our COBRE Investigators, 2) evaluate and manage the effectiveness of research cores and pilot projects, 3) implement and expand multidisciplinary enrichment programs and, 4) assist with grant applications, management and compliance issues.