Molecular Mechanisms and Genetics of Autoimmunity COBRE

描述（由申请人提供）：俄克拉荷马州医学研究基金会的十年COBRE，“自身免疫的分子机制和遗传学”（GM 103456）在为了解我们州自身免疫性疾病的分子和遗传基础提供增长基础方面具有变革性。该COBRE提供指导，资金和基础设施支持，以启动多个独立的研究事业，并授予“非COBRE”计划或中心赠款，大大扩大了俄克拉荷马州的研究基地。OMRF和俄克拉荷马州现在可以合法地声称自己是美国自身免疫遗传学和基因组学的“中心”。我们现在建议发展到财务和运营独立的两个关键研究核心，这两个核心在我们以前的成功中发挥了重要作用。基因组学核心（以前的核酸核心）从一开始就是COBRE的一个组成部分。现在，该核心配备了下一代测序和高通量基因分型能力，可为40多个用户的研究项目生成所需的基因组数据。定量分析核心（QAC）成立于10年，由两个现有的核心合并而成，一个专注于统计学，另一个专注于生物信息学。QAC为COBRE研究人员提供了一个由数据分析师、统计学家和生物信息学家组成的综合小组，提供了从研究设计、功效估计、统计分析和高维数据建模等方面的全方位支持。除了研究核心之外，我们的COBRE第三阶段还支持试点计划和管理核心。试点项目核心将通过为期一年的试点项目，确定、支持和指导符合COBRE资格的年轻科学家。我们将这些试点基金视为我们在俄克拉荷马州基因组学研究基地未来计划的基础。行政核心将为COBRE科学家提供行政支持，实施和扩大多学科浓缩计划，并评估试点项目的有效性。OMRF将继续通过持续和扩大对工资、资本设备、实验室空间和教师招聘的支持与COBRE合作。我们相信，在第三阶段COBRE的支持下，OMRF和俄克拉荷马州将拥有一个出色的基因组学中心。

DESCRIPTION (provided by applicant): The Oklahoma Medical Research Foundation's ten-year COBRE, "Molecular Mechanisms and Genetics of Autoimmunity (GM 103456) has been transformative in providing the foundation for growth in understanding the molecular and genetic basis of autoimmune diseases in our state. This COBRE provided mentoring, funding and infrastructure support to launch multiple independent research careers and the awarding of "non-COBRE" program or center grants, greatly expanding the research base in Oklahoma. OMRF and Oklahoma can now legitimately claim to be a "Center" for Autoimmunity Genetics and Genomics in the United States. We now propose to develop to financial and operational independence two key research cores that were instrumental in our previous success. The Genomics core (formerly the Nucleic Acids Core) has been a component of this COBRE since it's beginning. Now equipped with next generation sequencing and high-throughput genotyping capability, this core generates the genomic data needed for the research projects of over 40 users. The Quantitative Analysis Core (QAC) was formed in year 10 through a merger of two existing cores, one focusing on statistics and the other on bioinformatics. The QAC provides COBRE investigators with access to an integrated group of data analysts, statisticians and bioinformaticists offering a full range of support from study design, power estimates, statistical analysis, and high dimensional data modeling. In addition to the research cores our COBRE Phase III supports Pilot Program and Administrative Cores. The pilot project core will identify, support and mentor COBRE eligible junior scientists through one year pilot projects. We view these pilot funds as a fundamental to our plans for the future of our genomics research base in Oklahoma. The Administrative core will provide administrative support to COBRE scientists, implement and expand multidisciplinary enrichment programs and evaluate the effectiveness of the pilot projects. OMRF will continue to partner with this COBRE through sustained and expanding support of salaries, capital equipment, laboratory space and faculty recruitment. We are confident that with Phase III COBRE support OMRF and Oklahoma will have an outstanding Genomics Center.