CORE A: ADMINISTRATIVE CORE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 行政核心是科布雷的“中枢神经系统”，起着管理中心的作用，是科布雷的检查点，指导有效性初级调查员的发展。行政核心还将帮助初级调查员减轻与研究项目有关的行政职责(即，赠款管理、人类科目培训、IRB申请和合规、IACUC申请和合规、差旅安排、预算管理、人类科目招生以及人员招聘和留用)。行政核心将协助准备报告、会议、研讨会、重要的科学访问者和手稿的准备工作。内部(行政咨询委员会)和外部(行政咨询委员会)咨询委员会会议将在行政核心主持下举行。他们的决定将由行政核心执行。行政核心将向内部和外部咨询委员会提交进度报告。行政核心将由首席和联合首席调查员、导师和助理导师、内部和外部咨询委员会以及科布雷署长组成。初级调查员的R01提案将由行政核心予以协助和批评，并安排内部和外部审查员。行政核心将处理和评价由征聘核心确定的合格准初级调查员的提案。新的初级调查人员预计将对自身免疫有职业兴趣，可能在俄克拉何马州，但更有可能在招聘时在其他地方工作。新的Cobre初级调查员的机会将出现在当前初级调查员获得R01 NIH资金并从Cobre Support或以其他方式独立于Cobre Support的情况下。所有四个行政核心部分(外部咨询委员会、内部咨询委员会、导师和科布雷行政部门)将努力实现科布雷在俄克拉何马州建设研究基础设施和发展独立调查人员的目标。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Administrative Core is the "central nervous system" of this COBRE functioning as governing center and the checkpoint of the COBRE, mentoring effectiveness Junior Investigator development. The Administrative Core will also help unburden the Junior Investigators with the administrative duties associated with research projects (i.e., grants management, human subject training, IRB application and compliance, IACUC application and compliance, travel arrangements, budget management, human subject enrollment, and personnel recruitment and retention). The Administrative Core will facilitate presentation preparations, meetings, seminars, important scientific visitors, and manuscript preparation. The Internal (IAC) and External (EAC) Advisory Committee meetings will be held under the auspices of the Administrative Core. Their decisions will be implemented by the Administrative Core. The Administrative Core will make progress reports to the Internal and External Advisory Committees. The Administrative Core will consist of the Principal and Co-Principal Investigators, the Mentors and Assistant Mentors, the Internal and External Advisory Committees and the COBRE Administrator. The R01 proposals by Junior Investigators will be facilitated and criticized by the Administrative Core, where internal and external reviewers will be arranged. The Administrative Core will process and evaluate proposals from qualified prospective Junior Investigators ascertained by the Recruiting Core. New Junior Investigators are expected to have a career interest in autoimmunity, and may be in Oklahoma and but are more likely to be working elsewhere at the time of recruitment. Opportunity for new COBRE Junior Investigators will occur as the current Junior Investigators obtain R01 NIH funding and "graduate" from COBRE support or otherwise separate from COBRE support. All four Administrative Core components (the External Advisory Committee, the Internal Advisory Committee, Mentors, and COBRE Administration) will work toward realizing the COBRE purposes of building research infrastructure in Oklahoma and of developing independent investigators.