Center for AIDS Research
Center for AIDS Research
批准号:
8053594
负责人:
Fred T Valentine
金额:
$91.69万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-07-01 至 2012-06-30
中文摘要
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英文摘要
DESCRIPTION (provided by applicant): The Center for AIDS Research at NYU Medical Center comprises seventy clinical and basic science investigators performing research in three contiguous institutions in lower Manhattan and one across the river in Newark. These scientists are affiliated with the NYU School of medicine, although their laboratories and research clinics are located at the Manhattan VA Hospital, Bellevue Hospital, the New York Public Health Research Institute, as well as the School of Medicine buildings, including Tisch Hospital and Skirball Institute. Many important contributions to our understanding of the virology, immunology, epidemiology, and the infections and neoplastic complications of this disease have been made by NYU investigators since they identified their first patient in 1980. NYU clinicians are caring for over 4,000 HIV-infected individuals, and our clinical research efforts attract additional patients from the several thousands of HIV + subjects throughout the metropolitan region. This research is currently supported by over $25 M in AIDS-related funding, which includes over $15 M in yearly funding from the NIH. The CFAR supports this productive program of research and increases its efficiency by four shared core facilities, and developmental funds to support young investigators and new research opportunities. The CFAR also brings together investigators with similar interests into several research programs to facilitate innovation and collaboration.
CORE A: Administrative Core (Valentine, F)
DESCRIPTION (provided by applicant): The Administration Unit (Core) provides overall leadership and administrative management to the CFAR. The Administration is directed by Fred Valentine, M.D., with the support of two Associate Directors, Dan Littman, M.D., Ph.D. for Basic Science and William Borkowsky, M.D., for Clinical Research. The responsibilities of the Administration fall into two categories: 1) Providing proactive leadership in expanding HIV-related collaborative and translational research, 2) Ensuring that the multiple elements of the Center function together as a Center, that the whole is in fact greater than the sum of its parts. The senior leadership establishes the goals of the Center and, through the Center's programmatic and core structure, creates the optimal environment for interaction, growth and support of HIV research. The Director also works with the Administrators, Ms. Andrea Barrett and Irini Albanti, to ensure the smooth operation of the Center's chief administrative functions. These include: policies to guide the CFAR operations; budgetary stewardship; internal and external communication systems; planning and evaluation of CFAR activities, helping investigators and working with the development office on fund raising for CFAR. The Administrative Core functions primarily to provide the administrative support systems and management tools needed to maintain the CFAR's activities. This Core is responsible for fostering and tracking the scientific productivity and progress of its members. The Core also organizes and expands our outreach and international scientific and educational activities.
期刊论文(192)
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Exclusion of HIV coreceptors CXCR4, CCR5, and CCR3 from the HIV envelope.
将 HIV 辅助受体 CXCR4、CCR5 和 CCR3 从 HIV 包膜中排除。
DOI:
10.1089/088922299310601
发表时间:
1999
期刊:
AIDS research and human retroviruses.
影响因子:
--
作者:
[Lallos,LB, Laal,S, Hoxie,JA, Zolla-Pazner,S, Bandres,JC]
通讯作者:
Bandres,JC
HIV phenotype correlates with the relative amounts of lymphocyte function-related molecule 1 (LFA-1) and major histocompatibility complex (MHC) class II in the virion envelope.
HIV 表型与病毒颗粒包膜中淋巴细胞功能相关分子 1 (LFA-1) 和主要组织相容性复合体 (MHC) II 类的相对量相关。
DOI:
10.1097/00002030-200007280-00008
发表时间:
2000
期刊:
AIDS (London, England)
影响因子:
--
作者:
[BastianiLallos,L, Cecilia,D, Fenyö,EM, Laal,S, Zolla-Pazner,S]
通讯作者:
Zolla-Pazner,S
Synergy between human monoclonal antibodies to HIV extends their effective biologic activity against homologous and divergent strains.
人类 HIV 单克隆抗体之间的协同作用扩展了它们针对同源和不同菌株的有效生物活性。
DOI:
10.1089/aid.1992.8.425
发表时间:
1992
期刊:
AIDS research and human retroviruses
影响因子:
1.5
作者:
[Buchbinder,A, Karwowska,S, Gorny,MK, Burda,ST, Zolla-Pazner,S]
通讯作者:
Zolla-Pazner,S
Cooperation between viral interferon regulatory factor 4 and RTA to activate a subset of Kaposi's sarcoma-associated herpesvirus lytic promoters.
病毒干扰素调节因子 4 和 RTA 合作激活卡波西肉瘤相关疱疹病毒裂解启动子的子集。
DOI:
10.1128/jvi.00694-11
发表时间:
2012
期刊:
Journal of virology
影响因子:
5.4
作者:
[Xi,Xiangmei, Persson,LindaM, O'Brien,MichaelW, Mohr,Ian, Wilson,AngusC]
通讯作者:
Wilson,AngusC
HIV risk-related sexual behaviors among heterosexuals in New York City: associations with race, sex, and intravenous drug use.
纽约市异性恋者中与艾滋病毒风险相关的性行为:与种族、性别和静脉注射毒品的关系。
DOI:
10.1097/00002030-199303000-00016
发表时间:
1993
期刊:
AIDS (London, England)
影响因子:
--
作者:
[Kim,MY, Marmor,M, Dubin,N, Wolfe,H]
通讯作者:
Wolfe,H
共 95 条
Administrative
-
批准号:8134715
-
项目类别:
-
资助金额:$22.76万
-
财政年份:2010
-
负责人:Fred T Valentine
-
依托单位:
Immunopathogenesis of acute and early HIV infection
-
批准号:7901307
-
项目类别:
-
资助金额:$43.7万
-
财政年份:2009
-
负责人:Fred T Valentine
-
依托单位:
CD4 RESPONSES TO ANTIRETROVIRAL THERAPY (ART) ALONE OR ART WITH VACCINATION
-
批准号:7718428
-
项目类别:
-
资助金额:$95.62万
-
财政年份:2008
-
负责人:Fred T Valentine
-
依托单位:
CD4 RESPONSES TO ANTIRETROVIRAL THERAPY (ART) ALONE OR ART WITH VACCINATION
-
批准号:7605744
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项目类别:
-
资助金额:$41.27万
-
财政年份:2007
-
负责人:Fred T Valentine
-
依托单位:
CD4 RESPONSES TO ANTIRETROVIRAL THERAPY (ART) ALONE OR ART WITH VACCINATION
-
批准号:7378339
-
项目类别:
-
资助金额:$11.7万
-
财政年份:2006
-
负责人:Fred T Valentine
-
依托单位:
ADMINISTRATIVE CORE
-
批准号:6936123
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项目类别:
-
资助金额:$30.7万
-
财政年份:2005
-
负责人:Fred T Valentine
-
依托单位:
ACTG A5116: PROTEASE INHIBITOR SPARING REGIMENS V NUCLEOSIDE-SPARING REGIMENS
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批准号:7207071
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项目类别:
-
资助金额:$0.26万
-
财政年份:2005
-
负责人:Fred T Valentine
-
依托单位:
ACTG A5082: METFORMIN & ROSIGLITAZONE IN HIV+ PTS W/ INSULIN & FAT ABNORMALITIES
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批准号:7207082
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项目类别:
-
资助金额:$0.77万
-
财政年份:2005
-
负责人:Fred T Valentine
-
依托单位:
ACTG A5150: VIROLOGIC & IMMUNOLOGIC CHANGES IN WOMEN WITH HIV DURING POSTPARTUM
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批准号:7207139
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项目类别:
-
资助金额:$0.26万
-
财政年份:2005
-
负责人:Fred T Valentine
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依托单位:
OAR Supplement
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批准号:7124499
-
项目类别:
-
资助金额:$35.91万
-
财政年份:2005
-
负责人:Fred T Valentine
-
依托单位:
ACTG 5084: METABOLIC COMPLICATIONS IN HIV-1-INFECTED PREGNANT WOMEN ON ART
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批准号:7207088
-
项目类别:
-
资助金额:$0.13万
-
财政年份:2005
-
负责人:Fred T Valentine
-
依托单位:
ACTG A5150: VIROLOGIC & IMMUNOLOGIC CHANGES IN WOMEN WI
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批准号:6974389
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项目类别:
-
资助金额:$0.08万
-
财政年份:2004
-
负责人:Fred T Valentine
-
依托单位:
AUGMENTATION OF IMMUNE RESPONSE THROUGH VACCINATION IN INDIVIDUALS ON HAART
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批准号:6974328
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项目类别:
-
资助金额:$0.63万
-
财政年份:2004
-
负责人:Fred T Valentine
-
依托单位:
ACTG A5092s: Pharmacokinetic Effects of RBV on ZDV or d4T Triphosphate Formation
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批准号:6974338
-
项目类别:
-
资助金额:$1.27万
-
财政年份:2004
-
负责人:Fred T Valentine
-
依托单位:
Immune responses to acute HIV infection
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批准号:6808337
-
项目类别:
-
资助金额:$14.32万
-
财政年份:2004
-
负责人:Fred T Valentine
-
依托单位:
Immunological control of HIV in vivo
-
批准号:6808334
-
项目类别:
-
资助金额:$14.26万
-
财政年份:2004
-
负责人:Fred T Valentine
-
依托单位:
ACTG A5143: Lopinavir (LPV)/Ritonavir (RTV) vs GW433908/RTV vs LPV/RTV/GW433908
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批准号:6974335
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项目类别:
-
资助金额:$1.27万
-
财政年份:2004
-
负责人:Fred T Valentine
-
依托单位:
ACTG A5173:CLEARANCE OF HIV-1 IN CD4+ CELLS OF SUBJECTS ON T-20 PLUS ORAL AR
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批准号:6974384
-
项目类别:
-
资助金额:$0.24万
-
财政年份:2004
-
负责人:Fred T Valentine
-
依托单位:
ACTG 362: Azithromycin Prophylaxis for Primary Prevention of MAC in AIDS
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批准号:6974253
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项目类别:
-
资助金额:$0.79万
-
财政年份:2004
-
负责人:Fred T Valentine
-
依托单位:
ACTG A5116: Protease Inhibitor Sparing Regimens v. Nucleoside-Sparing Regimens
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批准号:6974287
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项目类别:
-
资助金额:$1.98万
-
财政年份:2004
-
负责人:Fred T Valentine
-
依托单位:
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基于病人旅程地图的HIV/AIDS患者双轨调适策略的混合性研究
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批准号:2026JJ81431
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项目类别:省市级项目
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资助金额:--
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批准年份:2026
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负责人:夏友
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依托单位:
基于潜变量增长混合模型的HIV/AIDS患者症状负担发展轨迹研究
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批准号:
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项目类别:省市级项目
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资助金额:--
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批准年份:2025
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负责人:胡亚丽
-
依托单位:
基于RET理论模型下的曼陀罗彩绘疗法在老年HIV/AIDS患者中的心理干预研究
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批准号:2025JJ80476
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项目类别:省市级项目
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资助金额:--
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批准年份:2025
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负责人:余一知
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依托单位:
IL-33/NF-κB通路在臭氧暴露致HIV/AIDS患者免疫损伤中的调控机制研究
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批准号:
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项目类别:省市级项目
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资助金额:--
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批准年份:2025
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负责人:
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依托单位:
IL-6与VV-ECMO治疗AIDS合并重度ARDS患者预后的相关性探索
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批准号:2025JJ80496
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项目类别:省市级项目
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资助金额:--
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批准年份:2025
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负责人:黄康
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依托单位:
HIV/AIDS患者症状群轨迹、影响因素及其对机会性感染的预测作用
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批准号:
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项目类别:省市级项目
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资助金额:--
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批准年份:2024
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负责人:陆俊雯
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依托单位:
基于社会心理行为表型组的HIV/AIDS患者高危性行为精准干预策略研究
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批准号:2023JJ40787
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项目类别:省市级项目
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资助金额:--
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批准年份:2023
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负责人:肖雪玲
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依托单位:
SIV猕猴感染模型中共生病毒组的演化特征及其参与AIDS进展的机制研究
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批准号:32370153
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项目类别:面上项目
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资助金额:50万元
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批准年份:2023
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负责人:李龑鹏
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依托单位:
求助者中心疗法在HIV/AIDS合并外科疾病手术治疗患者中的应用研究
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批准号:2023JJ60392
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项目类别:省市级项目
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资助金额:--
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批准年份:2023
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负责人:夏友
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依托单位:
边境流动人群HIV/AIDS感染的非恒等动力系统复杂网络构建及防控策略优化的研究
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批准号:72274086
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项目类别:面上项目
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资助金额:45万元
-
批准年份:2022
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负责人:李静
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依托单位: