Musculoskeletal Disorder in Dialysis Patients

透析患者的肌肉骨骼疾病

基本信息

批准号：
7993824
负责人：
Sharon M Moe
金额：
$ 4.99万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-12-07 至 2010-12-06
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7993824
关键词：
Albumins Albuminuria Anemia Angiotensin II Blood Blood Vessels Body Weight decreased C-terminal Calcium Cardiac Cattle Cell Culture Techniques Cells Chronic Chronic Kidney Failure Clinical Research Cross-Over Studies Cyclic AMP Cyclic AMP-Dependent Protein Kinases Data Analyses Development Dialysis patients Dialysis procedure Diet Dietary Proteins Disease Disease Progression Dominant-Negative Mutation Double-Stranded RNA End stage renal failure Enrollment Environment Erythropoietin Excretory function Exposure to Extramural Activities Faculty Feasibility Studies Funding Future Gadolinium Gene Expression Glomerular Filtration Rate Goals Grant Hazard Models Hemodialysis Hemoglobin Hepatitis C Hour Human Incubated Indiana Individual Inflammation Injury Insulin Insulin Resistance Intake Internal Medicine K-Series Research Career Programs Kidney Kidney Diseases Losartan Magnetic Resonance Imaging Manuscripts Measurement Measures Mentors Metabolism Mid-Career Clinical Scientist Award (K24)Minerals Morbidity - disease rate Musculoskeletal Diseases N-terminal Nephrology Non-Insulin-Dependent Diabetes Mellitus Obesity Operative Surgical Procedures Osteocalcin Osteoporosis Outcome Oxidative Stress Patients Peer Review Peptides Perfusion Physiologic pulse Production Protein Kinase C Protein-Restricted Diet Proteins Recording of previous events Recruitment Activity Regulation Renal Osteodystrophy Renal Tissue Research Research Personnel Research Project Grants Research Support Reverse Transcriptase Polymerase Chain Reaction Role Secondary Hyperparathyroidism Serum Signal Pathway Signal Transduction Small Interfering RNA Smooth Muscle Myocytes Surrogate Markers Techniques Testing Time Toxin Training Transactivation United States National Institutes of Health Vascular calcification Vitamin D Western Blotting Work Writing abstracting alpha-Fetoproteins amino-terminal parathyroid hormone autocrine bisphosphonate bone turnover calcification career development complement C2a complement C2b design diabetic experience hemodynamics inhibitor/antagonist meetings mineralization mortality osteopontin patient oriented research protein expression receptor renal hypoxia research study response tissue oxygenation urinary

项目摘要

The purpose of this proposal is to support protected time for Dr. Sharon Moe to continue her own clinical research and to mentor new investigators in the musculoskeletal diseases observed in dialysis patients. Dr. Moe has a proven track record in patient oriented research, strong mentoring history, and continuous extramural funding for translational and patient oriented research projects. Her long term research goals are to understand and treat the interrelated disorders of altered mineral metabolism, abnormal bone turnover, and increased vascular calcification in patients with chronic kidney disease (CKD), all associated with increased morbidity and mortality. During the 5 years of her previous K24, Dr. Moe has or is mentoring 13 individuals, 4 faculty (one with a K01, one with a pending K23, and one with an ADA career development award), 1 internal medicine housestaff (now a Nephrologist), and 8 Nephrology trainees (3/6 have completed their training and remain in academics). During the present K24 award, Dr. Moe has 29 peer-reviewed manuscripts, 20 of which include mentees as authors, in topics of vascular calcification and renal osteodystrophy. Dr. Moe's mentoring plan includes 1) regular meetings with mentees to discuss their research project and career development, 2) design and work on an investigator initiated project, 3) experience writing grants, abstracts, and manuscripts, 4) experience with presentation of results at national meetings, and 5) exposure to inter-disciplinary collaborative research. The research planned for the K24 renewal include projects to evaluate the role of mechanisms of vascular calcification and the role of alternative forms of dialysis, inflammation, and fetuin-A in calcification. Other studies will compare the use of inactive versus active vitamin D to treat secondary hyperparathyroidism in CKD, the role of bisphosphonates in the treatment of vascular calcification and osteoporosis in dialysis patients, and the relationship of hepatitis C and CKD. These studies, Dr. Moe, and the strong clinical research support at Indiana Unviersity provide an excellent training environment for the development of future investigators in patient oriented research.

该建议的目的是支持Sharon Moe博士继续自己的临床的保护时间研究并指导透析患者观察到的肌肉骨骼疾病的新研究者。博士 Moe在以患者为导向的研究，强大的指导历史和连续的方面具有良好的记录用于转化和患者的研究项目的壁外资金。她的长期研究目标是了解和治疗矿物质代谢改变，异常骨转换的相互关联疾病，并增加了慢性肾脏疾病（CKD）患者的血管钙化，所有这些都与发病率和死亡率增加。在她以前的K24的5年中，Moe博士拥有或正在指导13 个人，4个教职员工（一个有K01，一个有待定K23的教师，还有ADA职业发展奖项），1个内科医学Housestaff（现为肾脏科医生）和8名肾脏病学员（3/6已完成他们的培训并留在学者中）。在现任K24奖中，MOE博士进行了29次同行评审手稿，其中20个包括受训者作为作者，在血管钙化和肾脏主题中骨营养不良。 MOE博士的指导计划包括1）与受训者的定期会议讨论他们的研究项目和职业发展，2）设计和研究调查员发起的项目，3）经验写作赠款，摘要和手稿，4）在国家表现出现结果的经验会议和5）接触跨学科的合作研究。该研究计划的K24 更新包括评估血管钙化机制作用的项目和钙化中透析，炎症和fetuin-a的替代形式。其他研究将比较非活性和活性维生素D治疗CKD中次级甲状旁腺功能亢进，双膦酸盐的作用在透析患者的血管钙化和骨质疏松症治疗中丙型肝炎和CKD。这些研究，MOE博士和印第安纳州企业的强大临床研究支持为开发未来的研究人员提供了出色的培训环境研究。

项目成果

期刊论文数量（17）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Distal calcific uremic arteriolopathy in a hemodialysis patient responds to lowering of Ca x P product and aggressive wound care.

血液透析患者的远端钙化性尿毒症动脉病对降低 Ca x P 产物和积极的伤口护理有反应。

DOI：
10.5414/cnp58238
发表时间：
2002
期刊：
Clinical nephrology
影响因子：
1.1
作者：
Russell,R;Brookshire,MA;Zekonis,M;Moe,SM
通讯作者：
Moe,SM

Precision of biomarkers to define chronic inflammation in CKD.

精确定义 CKD 慢性炎症的生物标志物。

DOI：
10.1159/000135692
发表时间：
2008
期刊：
American journal of nephrology
影响因子：
4.2
作者：
LaClair,Robert;O'Neal,Kalisha;Ofner,Susan;Sosa,MarceloJ;Labarrere,CarlosA;Moe,SharonM
通讯作者：
Moe,SharonM

Review article: Chronic kidney disease-mineral bone disorder: have we got the assays right?

评论文章：慢性肾病-矿物质性骨病：我们的检测方法正确吗？