An Integrated Platform for In Vivo Neuromuscular Stimulation and Recording Using

体内神经肌肉刺激和记录的集成平台

• 批准号: 8326607
• 负责人: James Ross
• 金额: $ 19.55万
• 依托单位: AXION BIOSYSTEMS, LLC
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8326607
• 关键词: Address; Advanced Development; Biocompatible; Blindness; Brain; Chronic; Cicatrix; Clinic; Coupling; Custom; Cutaneous; Data; Development; Devices; Diagnosis; Disease; Electrodes; Electronics; Epilepsy; Evaluation; Facial Muscles; Felis catus; Foundations; Future; Gastrocnemius Muscle; Goals; Implant; Injury; Laboratories; Measures; Mechanics; Microelectrodes; Modeling; Monitor; Movement; Muscle; Muscle Fatigue; Needles; Nervous System Physiology; Neuromuscular Diseases; Paralysed; Performance; Peripheral Nerves; Phase; Printing; Property; Prosthesis; Rattus; Research; Resolution; Sensorimotor functions; Signal Transduction; Site; Small Business Innovation Research Grant; Source; Spinal Cord; Spinal cord injury; Stimulus; Surface; System; Systems Integration; Techniques; Technology; Testing; Tissues; Validation; biomaterial compatibility; brain machine interface; clinical application; commercialization; comparative efficacy; density; electrical potential; implantable device; implantation; improved; in vivo; motor control; muscular system; nervous system disorder; neuromuscular; neuromuscular function; novel; polydimethylsiloxane; prototype; relating to nervous system; research and development; research study; retinal prosthesis; spatiotemporal; tool

DESCRIPTION (provided by applicant): The implementation of novel electrophysiological interfaces to the brain, spinal cord, peripheral nerves, and muscles holds great promise for research into nervous-system function and for the future development of prosthetic devices. The goal of this project is the development and commercialization of an integrated platform for in vivo interfacing at the surface of neural tissue and muscle using conformable microelectrode arrays (MEAs). These MEAs are microfabricated using a technology that implements multilayer wiring and electrodes on a compliant polydimethylsiloxane (PDMS) substrate, and that creates a raised well around each electrode to facilitate tight coupling to the tissue. Electronics are integrated using a novel via bonding packaging technology that implements a robust, high-density electrical connection to the soft MEA substrate. The custom electronics facilitate the simultaneous stimulation and recording of the tissue in order both to control and to measure electrical activity. The Phase I SBIR project has two research and development aims with the following subaims: (1A) fabricate and test the compliant, raised-well MEAs, (1B) integrate the MEAs with proprietary electronics using the via bonding technology, (2A) validate the system performance by stimulating and recording from muscle, and (2B) validate the biocompatibility of the device for chronic implantation. Aim 1 will create the integrated platform and test the capability and robustness of the technology for future commercialization. Aim 2 will provide novel research data that will exemplify the power of the platform as a tool for the study of neuromuscular function. The successful completion of these aims will demonstrate both the applicability and the future potential of the technology. This project will provide a powerful tool that, by interfacing at the tissue surface, bridges the gap between highly invasive penetrating electrode arrays and low-fidelity cutaneous interfaces. The platform will facilitate research into a broad range of neurological and neuromuscular disorders and will have the potential to enhance the advanced development of prostheses and brain-machine interfaces to address the treatment of these disorders. The range of research and clinical applications includes the study of motor control and neuromuscular diseases and disorders, the implementation of prostheses to address conditions as far ranging as spinal-cord injury and blindness, and the development of brain-machine interfaces for the diagnosis and subsequent treatment of epilepsy.

描述（由申请人提供）：实现与大脑、脊髓、外周神经和肌肉的新型电生理接口，对于神经系统功能的研究和假体器械的未来发展具有很大的前景。该项目的目标是开发和商业化的集成平台，在神经组织和肌肉的表面使用顺应性微电极阵列（MEA）在体内接口。这些MEA是使用一种技术微制造的，该技术在柔性聚二甲基硅氧烷（PDMS）基板上实现多层布线和电极，并且在每个电极周围创建凸起的井以促进与组织的紧密耦合。电子集成使用一种新的过孔键合封装技术，实现了一个强大的，高密度的电气连接到软MEA基板。定制的电子设备便于同时刺激和记录组织，以便控制和测量电活动。第I阶段SBIR项目有两个研发目标，包括以下子目标：（1A）制造和测试符合要求的凸起式MEA，（1B）使用通孔键合技术将MEA与专有电子器件集成，（2A）通过刺激和记录肌肉来验证系统性能，（2B）验证器械的生物相容性以进行长期植入。目标1将创建集成平台，并测试该技术的能力和鲁棒性，以供未来商业化使用。目标2将提供新的研究数据，以增强该平台作为神经肌肉功能研究工具的能力。这些目标的成功实现将证明该技术的适用性和未来潜力。该项目将提供一种强大的工具，通过在组织表面进行界面连接，弥合高度侵入性穿透电极阵列和低保真度皮肤界面之间的差距。该平台将促进对广泛的神经和神经肌肉疾病的研究，并有可能加强假体和脑机接口的先进开发，以解决这些疾病的治疗问题。研究和临床应用的范围包括运动控制和神经肌肉疾病和障碍的研究，修复术的实施，以解决脊髓损伤和失明等问题，以及开发用于癫痫诊断和后续治疗的脑机接口。