Simultaneous Stimulation and Recording in Scalable Multielectrode Arrays

描述（由申请人提供）：拟定研究利用新型电子和微制造技术创建可扩展的体外多电极阵列（MEA）技术。这项研究将使神经相互作用的研究以及神经疾病的理解和治疗取得快速进展。第一阶段涉及神经相关研究的两个重大进展。具体来说，目标1将开发可扩展的同时刺激和记录电子设备，以恢复传统上被刺激伪影掩盖的信号。恢复的数据，结合同时与数百个电极交互的能力，将提供单细胞和网络级神经活动的新测量方法。目标2将产生可扩展的和廉价的多井MEA，它可以与目标1中开发的电子设备结合使用，以产生高通量的神经工具集。第二阶段将进一步扩大规模，同时提供数据处理算法沿着实时信息提取和控制工具。这项研究使用新的电子和制造技术来创建更快，更低成本的神经研究方法。最终，这一发展将促进医学和科学发现，这将有利于治疗神经疾病，如帕金森氏症和癫痫。

DESCRIPTION (provided by applicant): The proposed study utilizes novel electronics and microfabrication techniques to create scalable, in-vitro Multielectrode Array (MEA) technologies. This research will enable rapid advancements in the study of neural interactions and in the understanding and treatment of neural disorders. Phase I involves two significant developments for neural related research. Specifically, Aim 1 will develop scalable simultaneous stimulation and recording electronics to recover signals traditionally obscured by stimulation artifacts. The recovered data, combined with the ability to simultaneously interact with hundreds of electrodes, will provide new measures of single-cell and network-level neural activity. Aim 2 will produce scalable and inexpensive multi- well MEAs, which can be used in conjunction with the electronics developed in Aim 1 to yield a high- throughput neural toolset. Phase 2 will generate further increases in scale, while providing data manipula- tion algorithms along with real-time information extraction and control tools. This research uses novel electronic and fabrication technologies to create faster, lower-cost methods for neural research. Ultimately, this development will facilitate medical and scientific discoveries that will benefit the treatment of neural disorders such as Parkinson's and epilepsy.