A Microneedle Array System for Transcutaneous Nerve Mapping

用于经皮神经标测的微针阵列系统

• 批准号: 8647434
• 负责人: James Ross
• 金额: $ 55.49万
• 依托单位: AXION BIOSYSTEMS, LLC
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8647434
• 关键词: 3-Dimensional; Algorithms; Area; Charge; Clinical; Computer software; Custom; Data; Development; Diagnosis; Diagnostic; Disease; Electrocardiogram; Electrodes; Electromyography; Electronics; Face; Foundations; Gel; Goals; Housing; Human; Individual; Intraoperative Monitoring; Maps; Medical; Microelectrodes; Microfabrication; Monitor; Morphologic artifacts; Needles; Nerve; Neural Conduction; Neuromuscular Diseases; Noise; Pain; Patients; Peripheral Nerves; Phase; Physicians; Preparation; Process; Research; Research Personnel; Research Project Grants; Resolution; Retinal blind spot; Signal Transduction; Skin; Sterility; Stimulus; Surface; System; Techniques; Technology; Therapeutic; Time; Training; Tweens; Variant; base; cost effective; data acquisition; density; electric impedance; flexibility; improved; innovation; instrument; manufacturing process; miniaturize; neural prosthesis; novel; patient safety; public health relevance; relating to nervous system; response; signal processing

PROJECT SUMMARY The proposed study combines novel electronics and microfabrication techniques to create a non-invasive, research platform for targeted stimulation and characterization of human peripheral nerves. This Phase II proposal involves two significant developments for high-resolution peripheral nerve interfacing. Aim 1 will develop high-resolution and low-noise skin surface electrode arrays. Each electrode within the array will consist of cost-effective micropatterned needles, which significantly decrease electrode impedance by pain- lessly piercing the topmost layer of skin, thereby providing high spatial resolution without sacrificing signal- to-noise ratio. Aim 2 will develop miniaturized stimulation and recording electronics to recover signals tra- ditionally obscured by stimulation artifacts. The recovered data, combined with the ability to simultaneously interact with dozens of skin-surface electrodes, will allow non-invasive mapping, characterization, and con- trol of peripheral nerves. In addition to reducing the complexity, pain, and training required to monitor and manipulate peripheral nerves, this platform will allow for continued innovation in disease diagnostics, sur- face electromyography, neural prosthetics, intraoperative monitoring, and therapeutic stimulation.

项目总结 这项拟议的研究结合了新的电子学和微制造技术，以创造一种非侵入性、 人类周围神经靶向刺激和表征的研究平台。这是第二阶段 该提案涉及高分辨率周围神经接口的两个重要发展。目标1将 研制高分辨率、低噪声的皮肤表面电极阵列。阵列内的每个电极将 由经济实惠的微图纹针组成，显著降低疼痛引起的电极阻抗- 不会穿透最上层的皮肤，从而在不牺牲信号的情况下提供高空间分辨率 噪声比。AIM 2将开发微型刺激和记录电子设备，以恢复信号传输 在心理上被刺激物遮挡住了。恢复的数据，再加上同时 与数十个皮肤表面电极相互作用，将允许非侵入性标测、表征和控制- 周围神经的巨魔。除了减少监控和培训所需的复杂性、痛苦和培训外 操控周围神经，这个平台将允许疾病诊断方面的持续创新， 面部肌电、神经假体、术中监测和治疗刺激。