Administration

行政、生物统计和临床支持核心 (A) 将提供基础设施 支持该计划的基础和临床研究部分。行政部门 核心部分将协调研究项目之间的整体相互作用 核心设施。这将包括准备手稿和进度报告以及维护 该计划的研究人员每周举行研究会议，以促进 定期审查组成项目的进展情况。另外，这个核心组件 将维持项目负责人之间每两周一次的战略规划会议的日历， 讨论与各个项目的长期目标及其互动相关的问题 总体计划，并将协调内部和外部部门对计划的定期监督 外部咨询小组由具有该计划相关专业知识的科学家组成。的 行政部分还将负责该方案的总体预算问题， 协调该计划与区域内其他行政实体之间的互动 机构，并提供后勤和科学支持以促进该部分的进展 项目。该核心将促进每个项目的参与和互动 生物统计学家，从该项目一开始就与该项目的研究人员密切合作。这个 核心的生物统计学部分将确保适当的统计参数 纳入该计划的研究设计中，以便体外、动物和患者 资源得到有效利用，并采用严格的方法进行解释和解释 临床前和临床研究结果的报告。该核心还将协调 对在该计划范围内进行的治疗研究的临床支持 促进及时提交机构同行评审协议，保持遵守 机构和联邦指导方针，并确保该计划的临床方面 与大学内现有的广泛资源无缝集成 匹兹堡癌症研究所。相关性：该核心将提供必要的管理、 促进项目研究任务所需的生物统计和临床支持专业知识 以及该程序中的其他核心。

The Administrative, Biostatistics, and Clinical Support Core (A) will provide the infrastructure support for the basic and clinical research components of this program. The Administrative component of the core will coordinate the overall interactions among the research projects and core facilities. This will include preparation of manuscripts and progress reports and maintaining the ongoing calendar of weekly research meetings among the program's investigators to facilitate regular review of the progress of the component projects. In addition, this component of the core will maintain the calendar of biweekly strategic planning meetings among the project leaders to discuss issues related to the long-range goals of the individual projects and their interactions with the overall program, and will coordinate periodic oversight of the program by the internal and external advisory groups composed of scientists with expertise relevant to the program. The administrative component will also be responsible for overall budgetary issues of the program, for coordinating interactions between the program and other administrative entities within the institution, and for providing logistical and scientific support to facilitate progress of the component projects. This core will promote the involvement and interactions of each project with a biostatistician, who has worked closely with the investigators of this program from its outset. This Biostatistics component of the core will ensure that appropriate statistical parameters are incorporated in the design of the studies of the program, so that in vitro, animal, and patient resources are used efficiently, and that rigorous methods are applied for the interpretation and reporting of the results of preclinical and clinical studies. This core will also coordinate the Clinical Support for therapeutic studies conducted within the context of this program by facilitating timely submission of protocols for institutional peer review, maintaining compliance with institutional and federal guidelines, and ensuring that the clinical aspects of this program are integrated seamlessly with the extensive existing resources available within the University of Pittsburgh Cancer Institute. Relevance: This core will provide the essential administrative, biostatistical and clinical support expertise needed to facilitate the research mission of the projects and other cores within this program.