Prevention of Preterm Birth in high Risk Nulliparous Patients

高危未产妇早产的预防

基本信息

  • 批准号:
    8602022
  • 负责人:
  • 金额:
    $ 35.8万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-01-10 至 2014-12-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION: Columbia University's Division of Maternal Fetal Medicine has an active and successful clinical research infrastructure. Coupled with this infrastructure is a large obstetrical population. They have made major contributions to multiple multicentered clinical trial groups including the Maternal Fetal Medicine Network. They are now applying along with Christiana Care Health Systems, Inc. for participation in the Nulliparous Network. Ronald Wapner, MD has a superior record of clinical research participation and will be the PI of this application. This center offers not only the clinical attributes required to be a successful participant but also brings the Network exceptional expertise in public health, epidemiology, genetics and epigenetics, placental pathology, and ultrasound. A concept proposal describing the development of an algorhithim to quantify preterm birth risk in nulliparous patients is provided. This study specifically evaluates the impact of the maternal and fetal inflammatory/infectious pathway on preterm birth and investigates the relative role and interactions between genotype, ethnic, cytokine levels, environmental exposures, and demographic factors suggested to increase preterm birth.
描述:哥伦比亚大学的母胎医学部有一个积极和成功的临床研究基础设施。与这一基础设施相结合的是庞大的产科人口。他们为多个多中心临床试验小组做出了重大贡献,包括孕产妇胎儿医学网络。他们现在沿着与Christiana Care Health Systems,Inc.一起申请。参与无产网络的机会罗纳德Wapner,MD具有上级临床研究参与记录,将担任本申请的PI。该中心不仅提供成为成功参与者所需的临床属性,还为网络带来了公共卫生,流行病学,遗传学和表观遗传学,胎盘病理学和超声方面的卓越专业知识。提供了一个概念提案,描述了一种算法的发展,以量化未经产患者的早产风险。本研究专门评估了母体和胎儿炎症/感染途径对早产的影响,并研究了基因型、种族、细胞因子水平、环境暴露和人口统计学因素之间的相对作用和相互作用,这些因素可能会增加早产。

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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RONALD WAPNER其他文献

RONALD WAPNER的其他文献

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{{ truncateString('RONALD WAPNER', 18)}}的其他基金

Prenatal Genetic Diagnosis by Genomic Sequencing: A Prospective Evaluation
通过基因组测序进行产前基因诊断:前瞻性评估
  • 批准号:
    10522736
  • 财政年份:
    2022
  • 资助金额:
    $ 35.8万
  • 项目类别:
ClinGen Expert Curation Panel for Severe Structural Anomalies and Stillbirth
ClinGen 严重结构异常和死产专家管理小组
  • 批准号:
    10173415
  • 财政年份:
    2021
  • 资助金额:
    $ 35.8万
  • 项目类别:
ClinGen Expert Curation Panel for Severe Structural Anomalies and Stillbirth
ClinGen 严重结构异常和死产专家管理小组
  • 批准号:
    10687993
  • 财政年份:
    2021
  • 资助金额:
    $ 35.8万
  • 项目类别:
Air Pollution and Risk of Placental Abruption in New York City
纽约市的空气污染和胎盘早剥的风险
  • 批准号:
    9096793
  • 财政年份:
    2015
  • 资助金额:
    $ 35.8万
  • 项目类别:
Pregnancy as a Window to Future Cardiovascular Health
怀孕是未来心血管健康的窗口
  • 批准号:
    8846134
  • 财政年份:
    2013
  • 资助金额:
    $ 35.8万
  • 项目类别:
Pregnancy as a Window to Future Cardiovascular Health
怀孕是未来心血管健康的窗口
  • 批准号:
    8577315
  • 财政年份:
    2013
  • 资助金额:
    $ 35.8万
  • 项目类别:
Prevention of Preterm Birth in high Risk Nulliparous Patients
高危未产妇早产的预防
  • 批准号:
    8605890
  • 财政年份:
    2010
  • 资助金额:
    $ 35.8万
  • 项目类别:
Prevention of Preterm Birth in high Risk Nulliparous Patients
高危未产妇早产的预防
  • 批准号:
    8013035
  • 财政年份:
    2010
  • 资助金额:
    $ 35.8万
  • 项目类别:
Prevention of Preterm Birth in high Risk Nulliparous Patients
高危未产妇早产的预防
  • 批准号:
    8204601
  • 财政年份:
    2010
  • 资助金额:
    $ 35.8万
  • 项目类别:
Prevention of Preterm Birth in high Risk Nulliparous Patients
高危未产妇早产的预防
  • 批准号:
    7791022
  • 财政年份:
    2010
  • 资助金额:
    $ 35.8万
  • 项目类别:

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