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Escape from Homeostasis: Integrated Mathmatical and Experimental Investigation

Escape from Homeostasis: Integrated Mathmatical and Experimental Investigation
逃离稳态:综合数学和实验研究
批准号:
8567244
负责人:
Alexander Robertson Allan Anderson
金额:
$174.02万
依托单位国家:
美国
项目类别:
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-09-01 至 2015-08-31

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中文摘要
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英文摘要
Project Summary. Epithelial cell behavior is tightly regulated by the surrounding mE. This control is mediated through the coordinated actions of cell-cell adhesion, paracrine/autocrine growth factors and through adhesion to the extracellular matrix. Together, these mechanisms ensure that cells do not proliferate inappropriately or stray from their immediate mE niche. The process of oncogenic transformation and tumor progression entails the escape from these mechanisms, and the evolution ofthe tumor cell population towards phenotypes that allow them to become independent ofthe normal tissue mE. Activation ofthe underlying stromal fibroblasts, leading to the increased production of paracrine growth factors and pro-survival ECM is one way that developing tumors can achieve mE independence. The complexity of the host-tumor interaction in the carcinogenic process lends itself well to integrated experimental/mathematical based approaches, which are designed to handle multiple variables simultaneously. The current project will initially consider the mechanisms which control normal tissue homeostasis and subsequently homeostatic escape by using three different modeling approaches that examine the roles physical constraints, cell-mE interactions and evolutionary dynamics play in carcinogenesis. In the second part we will use novel in vitro organotypic cell culture models to test whether the presence of an activated stroma can provide the second
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Core 1: Mathematical Core
  • 批准号:
    10730408
  • 项目类别:
  • 资助金额:
    $40.61万
  • 财政年份:
    2023
  • 负责人:
    Alexander Robertson Allan Anderson
  • 依托单位:
Administrative Core
  • 批准号:
    10730404
  • 项目类别:
  • 资助金额:
    $22.04万
  • 财政年份:
    2023
  • 负责人:
    Alexander Robertson Allan Anderson
  • 依托单位:
Project 1: Delta immune Ecology of NSCLC
  • 批准号:
    10730405
  • 项目类别:
  • 资助金额:
    $50.07万
  • 财政年份:
    2023
  • 负责人:
    Alexander Robertson Allan Anderson
  • 依托单位:
The Delta Ecology of NSCLC Treatment
  • 批准号:
    10730403
  • 项目类别:
  • 资助金额:
    $208.93万
  • 财政年份:
    2023
  • 负责人:
    Alexander Robertson Allan Anderson
  • 依托单位:
海外基金