California Center of BD-STEPS - Finding Causes and Preventives of Birth Defects

摘要 出生缺陷是美国婴儿死亡的主要原因。出生缺陷也有巨大的关联 情感和财政成本。加州中心独立和合作的研究努力 其他出生缺陷研究和预防中心(CBDRP)为全国出生做出贡献 出生缺陷预防研究(NBDPS)一直是公共卫生领域出生缺陷研究的前沿。使用 在这一新的资金机会下，我们中心将进一步提高对潜在原因的科学认识 具体的出生缺陷，这无疑将对风险评估和预防具有重要意义 常见、昂贵且致命的畸形。在本申请中，我们提出了以下目标： 目标1.加强出生缺陷和保健中心的流行病学公共卫生研究能力 积极参与出生缺陷研究评估妊娠的研究与预防 曝光(BD-STEP)和 目标2.利用BD-STEPS和NBDPS的数据进行协作和当地研究，以确定 选定出生缺陷的潜在可改变危险因素，以减轻出生时的公共卫生负担 美国的缺陷。 加州中心装备齐全，可以为BD-STEPS做出贡献-它是出生缺陷方面的世界领先者 流行病学，在信息的开发、数据收集和传播方面经验丰富 以人口为基础的出生缺陷研究，以其在CBDRP中的表现和高度的 创新的研究组合。我们的中心有丰富的经验进行与屋宇署相关的研究- 步骤重点领域，包括产妇慢性疾病、糖尿病、肥胖症、体力活动、 不孕不育和药物使用。我们已经提出了几个分析性查询，并使用 其他创新数据集和分析方法，这将使我们能够协作地继续 阐明这些和其他可改变的危险因素对出生缺陷的贡献。

ABSTRACT Birth defects are the leading cause of infant mortality in the US. Birth defects also have enormous associated emotional and fiscal costs. The California Center's research efforts, both independently and in collaboration with other Centers for Birth Defects Research and Prevention (CBDRP) contributing to the National Birth Defects Prevention Study (NBDPS), have been at the forefront of public health birth defects research. With this new funding opportunity, our Center will further enhance scientific understanding of the potential causes of specific birth defects, which will undoubtedly have important implications for risk assessment and prevention of common, costly, and deadly malformations. In this application we propose the following aims: Aim 1. Enhance the epidemiologic public health research capacity of the Centers for Birth Defects and Research and Prevention by actively participating in the Birth Defects Study to Evaluate Pregnancy Exposures (BD-STEPS) and Aim 2. Utilize data from BD-STEPS as well as NBDPS for collaborative and local studies that will identify potential modifiable risk factors for selected birth defects to reduce the public health burden of birth defects in the US. The California Center is well-equipped to contribute to BD-STEPS - it is a world leader in birth defects epidemiology and highly experienced in the development, data collection and dissemination of information from population-based studies of birth defects, exemplified by its performance within the CBDRP and its highly innovative research portfolio. Our Center has extensive experience conducting research related to the BD- STEPS areas of focus, which include maternal chronic medical conditions, diabetes, obesity, physical activity, infertility and medication use. We have proposed several analytic inquiries, complemented by the use of additional innovative datasets and analytic approaches, which will enable us to collaboratively continue elucidating the contribution of these and other modifiable risk factors to birth defects.