Fault-tolerant Control Systems for Artificial Pancreas

人工胰腺的容错控制系统

• 批准号: 8643041
• 负责人: Ali Cinar
• 金额: $ 195.36万
• 依托单位: ILLINOIS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8643041
• 关键词: Adoption; Age; Algorithms; Artificial Pancreas; Behavior; Blood Glucose; Caring; Characteristics; Chicago; Child; Clinical Research; Collaborations; Communication; Complement; Computer software; Concentration measurement; Detection; Development; Devices; Diagnosis; Diagnostic; Dose; Event; Failure; Fright; Glucose; Goals; Health; Hyperglycemia; Hypoglycemia; Illinois; Industry; Infusion Pumps; Infusion procedures; Institutes; Insulin; Insulin Infusion Systems; Insulin-Dependent Diabetes Mellitus; Manuals; Manufacturer Name; Measurement; Medical; Methods; Modeling; Monitor; Patients; Performance; Physiological; Provider; Pump; Quality of life; Recovery; Regulation; Research; Risk; Signal Transduction; Software Tools; Source; System; Techniques; Technology; Time; Translations; Universities; Variant; base; design; glucose monitor; improved; novel strategies; operation; pancreas development; performance tests; repaired; sensor; tool; transmission process; young adult

DESCRIPTION (provided by applicant): Recent research on artificial pancreas (AP) systems produced various AP technologies with good performance in clinical studies and indicated the need for improving the reliability of daily use of AP by patients. Reliable and robust AP systems can be designed by integrating multivariable monitoring, fault detection and diagnosis, sensor redundancy, and fault-tolerant control techniques to provide self-recovery, safeguards against failures and warnings and messages to users and medical care providers. The proposed research focuses on the development of a fault-tolerant AP that integrates these technologies, mitigates the risks in AP systems and functions at an acceptable level for BGC regulation until the diagnosed fault can be repaired or can provide safe transfer to manual operation of insulin pumps by the user. Our research focus is on the development of multivariable algorithms and software tools for performance monitoring, fault detection and diagnosis, control system performance assessment, analytical redundancy in sensors, control algorithms with fault-tolerance and recovery, and warning systems to users and care providers to a create fault-tolerant AP system. The critical characteristics of our approach are the use of physiological variable information to complement continuous glucose measurements, multivariable modeling, monitoring, diagnosis and control techniques, and recursive models and adaptive model-based control systems. A multivariable simulator with multiple inputs (glucose concentration and physiological variables) will also be developed to test the performance monitoring, FDD, sensor redundancy, and fault- tolerant control modules and assess the performance of fault-tolerant AP system. Clinical studies will be conducted to test the performance of various modules and of fault-tolerant AP system. They will also be used to assess the potential of quality of life improvements and reduction of fear of hypoglycemia in AP use. The proposed research will be collaboration between Ali Cinar - Illinois Institute of Technology, Elizabeth Littlejohn - Universiy of Chicago, and Laurie Quinn - University of Illinois at Chicago, in partnership with Medtronic Corporation and Body-Media, inc.

描述（由申请人提供）：最近对人工胰腺（AP）系统的研究产生了各种AP技术，在临床研究中具有良好的性能，并表明需要提高患者日常使用AP的可靠性。通过集成多变量监测、故障检测和诊断、传感器冗余和容错控制技术，可以设计可靠和鲁棒的AP系统，以提供自我恢复、故障防护以及向用户和医疗保健提供者发出警告和消息。拟议的研究重点是开发一种容错AP，该AP集成了这些技术，减轻了AP系统中的风险，并在BGC调节的可接受水平下运行，直到诊断出的故障可以修复或可以由用户安全转移到胰岛素泵的手动操作。我们的研究重点是开发多变量算法和软件工具，用于性能监测，故障检测和诊断，控制系统性能评估，传感器分析冗余，具有容错和恢复的控制算法，以及用户和护理提供者的警告系统，以创建容错AP系统。我们的方法的关键特征是使用生理变量信息来补充连续葡萄糖测量，多变量建模，监测，诊断和控制技术，以及递归模型和基于模型的自适应控制系统。还将开发具有多个输入（葡萄糖浓度和生理变量）的多变量模拟器，以测试性能监测、FDD、传感器冗余和容错控制模块，并评估容错AP系统的性能。我们会进行临床研究，以测试各种模块和容错AP系统的性能。它们还将用于评估AP使用中改善生活质量和减少低血糖恐惧的潜力。拟议的研究将由Ali奇纳尔-伊利诺伊理工学院、Elizabeth Littlejohn -芝加哥大学和劳里Quinn -伊利诺伊大学芝加哥分校与Medtronic Corporation和Body-Media，Inc.合作进行。

项目成果

Model-Fusion-Based Online Glucose Concentration Predictions in People with Type 1 Diabetes.

• DOI: 10.1016/j.conengprac.2017.10.013
• 发表时间: 2018-03
• 期刊: Control engineering practice
• 影响因子: 4.9
• 作者: Yu X;Turksoy K;Rashid M;Feng J;Frantz N;Hajizadeh I;Samadi S;Sevil M;Lazaro C;Maloney Z;Littlejohn E;Quinn L;Cinar A
• 通讯作者: Cinar A

Meal Detection in Patients With Type 1 Diabetes: A New Module for the Multivariable Adaptive Artificial Pancreas Control System.

• DOI: 10.1109/jbhi.2015.2446413
• 发表时间: 2016-01
• 期刊: IEEE journal of biomedical and health informatics
• 影响因子: 7.7
• 作者: Turksoy K;Samadi S;Feng J;Littlejohn E;Quinn L;Cinar A
• 通讯作者: Cinar A

A Pilot Study Validating Select Research-Grade and Consumer-Based Wearables Throughout a Range of Dynamic Exercise Intensities in Persons With and Without Type 1 Diabetes: A Novel Approach.

一项试点研究，在 1 型糖尿病患者和非 1 型糖尿病患者的一系列动态运动强度中验证精选的研究级和消费者型可穿戴设备：一种新方法。

• DOI: 10.1177/1932296817750401
• 发表时间: 2018
• 期刊: Journal of diabetes science and technology
• 影响因子: 5
• 作者: Yavelberg,Loren;Zaharieva,Dessi;Cinar,Ali;Riddell,MichaelC;Jamnik,Veronica
• 通讯作者: Jamnik,Veronica

Automated Insulin Delivery-The Light at the End of the Tunnel.

自动胰岛素输送——隧道尽头的曙光。

• DOI: 10.1016/j.jpeds.2017.02.055
• 发表时间: 2017
• 期刊: The Journal of pediatrics
• 作者: Turksoy,Kamuran;Frantz,Nicole;Quinn,Laurie;Dumin,Magdalena;Kilkus,Jennifer;Hibner,Brooks;Cinar,Ali;Littlejohn,Elizabeth
• 通讯作者: Littlejohn,Elizabeth

Adaptive and Personalized Plasma Insulin Concentration Estimation for Artificial Pancreas Systems.

• DOI: 10.1177/1932296818763959
• 发表时间: 2018-05-01
• 期刊: Journal of diabetes science and technology
• 影响因子: 5
• 作者: Hajizadeh, Iman;Rashid, Mudassir;Cinar, Ali
• 通讯作者: Cinar, Ali