Life Course Socioeconomics, Acculturation, & Type-2 Diabetes Risk Among Latinos

生命历程社会经济学、文化适应、

• 批准号: 8825045
• 负责人: Allison E Aiello
• 金额: $ 17.83万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8825045
• 关键词: Life; Course; Socioeconomics; Acculturation; Type

DESCRIPTION (provided by applicant): Latinos in the US carry a disproportionate burden of type-2 diabetes. Research has implicated life course socioeconomic position as a major factor in the development of chronic diseases, such as type-2 diabetes; yet most evidence is limited to non-Hispanic White populations. We hypothesize that the large disparities in type-2 diabetes among Latinos reflects the joint effect of intergenerational transmission of socioeconomic factors, cultural characteristics, behaviors, biology, and other risk factors accumulating over the life course. The experience of Latinos in the US represents an especially fruitful context in which to investigate the influence of life course socioeconomic and cultural resources in relation to type-2 diabetes. In addition to being the fastest growing minority population with high rates of obesity and type-2 diabetes, the experience of Latinos is one that includes first generation immigrants with limited education and job skills, and later generations who are born and raised in the US and show varying levels of acculturation and assimilation, behavioral change, and socioeconomic advancement. With these unique considerations in mind, the present study seeks to: (1) examine the impact of life course socioeconomic position on type-2 diabetes among Latinos; (2) assess whether acculturation modifies the impact of life course socioeconomic position on type-2 diabetes among Latinos; and 3) examine whether metabolic and inflammatory markers related to behavioral, physiological, and psychosocial risk factors mediate the relationships between life course socioeconomic position, acculturation, and type-2 diabetes among Latinos. The proposed research activity will constitute the first systematic attempt to assess the unique and synergistic contributions of life course socioeconomic position and acculturation on type 2 diabetes among Latinos. By assessing life course exposures across two generations of Latinos living in the US, this project provides an unprecedented opportunity to identify targets for early intervention for reducing the heavy burden of type-2 diabetes among Latinos. More broadly, the proposed research may uncover crucial life course socioeconomic and cultural patterning of risk factors or health promoting characteristics that may also benefit other race/ethnic minorities disproportionately living in poverty and suffering from type-2 diabetes.

描述（由申请人提供）：美国的拉丁裔人承受着不成比例的 2 型糖尿病负担。研究表明，生命周期的社会经济地位是 2 型糖尿病等慢性病发展的主要因素；但大多数证据仅限于非西班牙裔白人群体。我们假设拉丁美洲人 2 型糖尿病的巨大差异反映了社会经济因素、文化特征、行为、生物学和其他风险因素在整个社会中积累的代际传播的共同影响。 生命历程。拉丁裔在美国的经历代表了一个特别富有成效的背景： 调查生命全程社会经济和文化资源对 2 型糖尿病的影响。除了是增长最快的少数族裔人口，肥胖和 2 型糖尿病发病率较高之外，拉丁裔的经历还包括教育和工作技能有限的第一代移民，以及在美国出生和长大的后代，他们表现出不同程度的文化适应和同化、行为改变和社会经济进步。考虑到这些独特的考虑因素，本研究旨在：（1）研究生命全程的社会经济地位对拉丁裔 2 型糖尿病的影响； (2) 评估文化适应是否改变了拉美裔生命历程中社会经济地位对 2 型糖尿病的影响； 3) 检查与行为、生理和心理社会风险因素相关的代谢和炎症标志物是否介导拉美裔人生命历程的社会经济地位、文化适应和 2 型糖尿病之间的关系。拟议的研究活动将构成首次系统性尝试，以评估拉丁美洲人生命周期社会经济地位和文化适应对 2 型糖尿病的独特和协同贡献。通过评估生活在美国的两代拉丁裔的生命历程暴露程度，该项目提供了前所未有的机会来确定早期干预目标，以减轻拉丁裔中 2 型糖尿病的沉重负担。更广泛地说，拟议的研究可能会揭示危险因素或健康促进特征的关键生命周期社会经济和文化模式，这也可能使其他不成比例地生活在贫困和患有 2 型糖尿病的种族/少数民族受益。