National Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Cognition and Early Risk Factors for Dementia Project

全国青少年至成人健康纵向研究（添加健康）：第六波认知和痴呆症早期危险因素项目

• 批准号: 10328574
• 负责人: Allison E Aiello
• 金额: $ 154.63万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-15 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10328574
• 关键词: Activities of Daily Living; Adolescence; Adolescent; Adult; Affect; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Behavioral; Biological; Biological Factors; Biological Markers; Biological Testing; Blood; Cognition; Cognitive; Collection; Communities; Companions; Country; Coupled; Data; Data Collection; Development; Diabetes Mellitus; Drug usage; Early Intervention; Early identification; Economics; Elderly; Foundations; Future; Gait; Goals; Gold; Health; Health and Retirement Study; Hearing; Hypertension; Impaired cognition; Lead; Life Cycle Stages; Longitudinal Studies; Measurement; Measures; Nerve Degeneration; Obesity; Online Systems; Participant; Pathway interactions; Persons; Physical Function; Physical assessment; Population; Protocols documentation; Research; Research Personnel; Risk; Risk Factors; Risk Marker; Sampling; Scientific Advances and Accomplishments; Sensory; Signs and Symptoms; Smell Perception; Smoking; Surveys; Symptoms; Testing; Time; United States; Validation; Venous; Vision; aging population; base; behavioral health; cognitive function; cognitive testing; cohort; dementia risk; early adolescence; ethnic diversity; experience; health disparity populations; innovation; instrument; middle age; physically handicapped; prevent; prospective; racial and ethnic; response; social; trend

Project Summary Alzheimer's Disease and Related Dementias (ADRD) are projected to affect 14 million Americans by 2050. To date, though, research on the signs and symptoms of ADRD has been sparse in early midlife populations, especially at the national level. It is crucial to conduct such research because early changes in cognitive functioning and the accumulation of risk factors for ADRD can begin decades before concrete signs and symptoms emerge. The challenging search for the causes of ADRD has made it clear that prospective and comprehensive data—including detailed social, biological, and health measurements across the life course— are needed to identify key predictors of ADRD. As such, the National Longitudinal Study of Adolescent to Adult Health (Add Health) provides an extraordinary opportunity to study the early origins of cognitive functioning/change and ADRD risk in a nationally representative cohort that has been followed since adolescence and will be in their mid-40s in the next wave of data collection (Wave VI). The overall goal of this project is to collect and disseminate critical data related to cognitive, physical, and sensory functioning in conjunction with the Add Health Wave VI Core Project to facilitate identification of early risk factors for later life ADRD. Adding such rich measures to Wave VI of Add Health will make possible tracking of cognitive, sensory, and physical functioning across the life course; coupled with the testing of biological risk markers, it will also lay the foundation for detecting signs of cognitive impairment and ADRD risk in early midlife. These new data, when combined with Add Health's existing 25-year collection of extraordinarily rich multi-level and longitudinal measures and its new Wave VI data, will also aid in the scientific community's understanding of the interplay of social, behavioral, and biological factors leading to ADRD in later life. Moreover, because Add Health is a very diverse sample, adding these data to Wave VI will greatly increase understanding of cognitive, physical, and sensory functioning within health disparity populations. The project's specific aims are to: 1) Collect new in- depth, in-person assessments of cognitive functioning in early midlife for a nationally representative and racially/ethnically diverse subsample of participants in Wave VI; 2) Collect automated, (largely) web-based measures of cognition in early midlife for all participants in Wave VI and compare them with our in-person measures of cognition to assess their feasibility and value; 3) Include assessments of physical and sensory functioning in early midlife for Wave VI participants of Add Health; 4) Test for biological markers of ADRD risk and cognitive function in early midlife; 5) Clean, document, disseminate, promote, and support the data collected in this project for the scientific community. All told, this project will collect and disseminate innovative data to thousands of researchers that will facilitate the rigorous study of cognition and risk factors for later life ADRD among a diverse nationally representative sample of early midlife Americans.

项目摘要 阿尔茨海默病和相关痴呆症（ADRD）预计到2050年将影响1400万美国人。到 然而，迄今为止，关于ADRD的体征和症状的研究在中年早期人群中很少， 特别是在国家一级。进行这样的研究是至关重要的，因为认知的早期变化 ADRD的功能和风险因素的积累可以在具体迹象出现之前开始几十年， 症状出现。对ADRD原因的挑战性研究清楚地表明， 全面的数据-包括整个生命过程中详细的社会，生物和健康测量- 来确定ADRD的关键预测因素。因此，国家青少年到成人的纵向研究 健康（添加健康）提供了一个非凡的机会，研究认知的早期起源， 功能/变化和ADRD风险的国家代表性队列，自 在下一波数据收集（第六波）中，他们将在40多岁。这个项目的总体目标是 项目是收集和传播有关认知，身体和感官功能的关键数据， 与Add Health Wave VI核心项目结合，以促进对晚年早期风险因素的识别 ADRD。将这些丰富的措施添加到添加健康的第六波将使跟踪认知，感官， 和身体功能在整个生命过程中;再加上生物风险标志物的测试，它也将奠定 在中年早期检测认知障碍和ADRD风险的基础。这些新数据， 当与Add Health现有的25年丰富的多层次和纵向 这些措施及其新的Wave VI数据，也将有助于科学界了解 社会，行为和生物因素导致ADRD在以后的生活。此外，由于添加健康是一个非常 多样化的样本，将这些数据添加到Wave VI将大大增加对认知，身体和 健康差异人群中的感觉功能。该项目的具体目标是：1）收集新的信息- 为一名全国代表对中年早期的认知功能进行深入的面对面评估， 第六波中种族/族裔多样化的参与者子样本; 2）收集自动化的、（大部分）基于网络的 在早期中年的认知措施，为所有参与者在第六波，并比较他们与我们的人 认知措施，以评估其可行性和价值; 3）包括身体和感官的评估 Add Health的第VI波参与者在中年早期的功能; 4）ADRD风险的生物标志物测试 5）清理、记录、传播、推广和支持数据 为科学界收集的信息。总之，这个项目将收集和传播创新的 这些数据将有助于对认知和晚年风险因素进行严格的研究 ADRD在不同的国家代表性样本的早期中年美国人。