Hormone and Metabolite Core

激素和代谢核心

• 批准号: 8463175
• 负责人: XAVIER PI-SUNYER
• 金额: $ 19.56万
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8463175
• 关键词: Acetaminophen; Adipocytes; Advertising; Animals; Biological Assay; Body Composition; Catecholamines; Cholecystokinin; Collaborations; Comorbidity; Data; Disease; Eating Disorders; High Pressure Liquid Chromatography; Hormones; Human; Individual; Laboratories; Mass Spectrum Analysis; Methodology; Methods; Mission; Molecular Genetics; Names; New York; Nutritional; Obesity; Phenotype; Plasma; Postdoctoral Fellow; Productivity; Regulation; Research; Research Personnel; Resources; Rodent Model; Services; Students; Technology; Training; Transplantation; adipokines; analytical method; base; cost; cytokine; design; energy balance; experience; glucagon-like peptide 1; glucose metabolism; instrumentation; lipid metabolism; meetings; member; metabolomics; new technology; nutrition; research study

The mission of the Hormone & Metabolite Core is to assist investigators by performing uniform and standardized assays of various plasma metabolites, hormones, adipokines and cytokines in rodent models and human studies related to the regulation of obesity and co-morbidities, energy balance, eating disorders and nutrition related problems. The assay services provided within this Core provide an integrative framework for understanding obesity and associated disorders in glucose and lipid metabolism. In addition, the data obtained directly relate to and integrate with the analyses performed in the Body Composition, Animal Energy Balance Phenotyping, the Adipocyte and the Molecular Genetic Cores ofthe Center. The services provided at the HMC are best based in a Core Laboratory because they require special instrumentation and methodology, which would be difficult or impracticably expensive to establish in the laboratories of the individual investigators who are Members ofthe NYONRC.

激素和代谢产物核心的使命是通过对啮齿动物模型中的各种血浆代谢产物，激素，脂肪因子和细胞因子进行均匀和标准化的测定，以及与肥胖，共生性，能量平衡，饮食障碍和与营养相关的问题有关的均匀和标准化测定。该核心内提供的分析服务为了解葡萄糖和脂质代谢中的肥胖症和相关疾病提供了一个综合框架。此外，获得的数据直接与人体组成，动物能量平衡表型，脂肪细胞和中心的分子遗传核心进行的分析有关。 HMC提供的服务最好基于核心实验室，因为它们需要特殊的仪器和方法论， 在NyonRC成员的个别调查人员的实验室中建立建立将是困难或不切实际的。