2013 Mammalian DNA Repair Gordon Research Conference and Gordon Research Seminar

描述(由申请人提供)：本提案请求部分支持召开哺乳动物DNA修复国际会议，戈登研究会议每隔一年举行一次，将于2013年2月10日至15日在加利福尼亚州文图拉举行。会议的目标是增加我们对DNA修复和信号传递机制的了解，以及它们如何影响人类健康，特别是癌症生物学和神经退行性疾病。这次会议将汇集37位受邀演讲者，他们拥有DNA修复和损伤反应的所有主要领域的专业知识，包括切除修复、双链断裂修复和错配修复，以及DNA损伤诱导的信号和复制叉处的损伤识别机制。我们还将讨论DNA损伤反应蛋白在基因组不稳定中的作用，因为它与癌症有关，一些发言者将讨论在合成致命性方法中利用DNA修复靶标的翻译方法。将从摘要中选出9个简短的演讲，以及4个两小时的海报会议，让所有参与者在非正式的环境中进行互动。此外，这也是第一次在2013年2月9日至10日的会议之前举办戈登研究研讨会，这是一个为期两天的研讨会，让研究生和博士后研究员学习该领域的基础知识，有机会发表演讲，并从同行那里获得关于他们的研究和演讲的反馈。哺乳动物DNA修复GRC是这一领域的一次非常重要的会议，因为参加会议的演讲者素质很高，会议的规模很亲密，而且这一会议被广泛认为是一次推动国际DNA修复研究的会议。该应用非常关注癌症病因、癌症治疗、神经退行性变和衰老，与人类健康和疾病密切相关。

DESCRIPTION (provided by applicant): This proposal requests partial support for an international meeting on Mammalian DNA Repair, a Gordon Research Conference that is held every other year and will be held in Ventura, California, Feb 10-15, 2013. The goals of the conference are to increase our understanding of the mechanisms of DNA repair and signaling and how they influence human health, with particular emphasis on cancer biology and neurodegenerative diseases. The meeting will bring together 37 invited speakers with expertise in all of the major areas of DNA repair and damage responses, including excision repair, double-strand break repair, and mismatch repair, as well as DNA damage-induced signaling and mechanisms of damage recognition at replication forks. We will also have sessions focused on the role of DNA damage response proteins in genomic instability as it relates to cancer, and a few speakers will address translational approaches that utilize DNA repair targets in synthetic lethality approaches. There will be 9 short talks chosen from abstracts, and 4 two-hour poster sessions that will allow all of the participants to interact in an informal setting. In addition, tis is the first year that this conference will also host a Gordon Research Seminar prior to the meeting, February 9 -10, 2013 which is a two-day workshop for graduate students and postdoctoral fellows to learn the basics of the field, to have the opportunity to give talks, and t get feedback about their research and their presentations from their peers. The Mammalian DNA Repair GRC is a very significant meeting in this field because of the high caliber of speakers who attend, the intimate scale of the meeting, and the fact that this meeting is widely known as one that propels the research in DNA repair internationally. The application is extremely relevant to human health and disease in its focus on cancer etiology, cancer treatment, neurodegeneration, and aging.