FASEB SRC on Genetic Recombination and Genome Rearrangements

FASEB SRC 关于基因重组和基因组重排

• 批准号: 8978686
• 负责人: TANYA T PAULL
• 金额: $ 0.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8978686
• 关键词: Adverse effects; American; Area; BRCA1 gene; BRCA2 gene; Biological; Biological Markers; Biology; Cancer Etiology; Cancer-Predisposing Gene; Chromosomes; Colorado; DNA Damage; DNA Double Strand Break; DNA Repair; Equilibrium; Fostering; Gene Expression Regulation; Gene Proteins; Genetic Models; Genetic Recombination; Genome; Human; Immune System Diseases; Information Technology; Knowledge; Malignant Neoplasms; Modality; Neurologic; Oncogenic; Participant; Pathway interactions; Pharmaceutical Preparations; Premature aging syndrome; Principal Investigator; Process; Radiation; Regulation; Research; Research Personnel; Role; Series; Societies; Syndrome; System; Techniques; Tumor Suppressor Genes; Tumor Suppressor Proteins; biological systems; cancer therapy; chemotherapy; crosslink; homologous recombination; improved; malignant breast neoplasm; new technology; novel strategies; prevent; programs; public health relevance; recombinational repair; repaired; symposium; unpublished works

 DESCRIPTION (provided by applicant): This application seeks partial support for the Federation of American Societies of Experimental Biology (FASEB) conference on Genetic Recombination and Genome Rearrangements to be held July 19-24, 2015 in Steamboat Springs, Colorado. This will be the 16th in a series of highly successful bi-annual conferences devoted to these topics. This conference aims to join investigators studying many diverse aspects of genetic recombination, in a range of biological systems and with different experimental approaches. Presentations will introduce new and unpublished work on timely questions in the field and will include discussion from all participants. The FASEB conference provides unique opportunities for the exchange of information and technology that can be appreciated and exploited across the recombination field. The conference covers many areas of significance for cancer. Homologous recombination is an important mechanism for preventing genome rearrangements that can promote the oncogenic state, and many genes/proteins involved in the mechanisms and regulation of recombination have been identified as tumor suppressor genes. Hence, studies of recombination mechanisms are paramount to understanding the etiology of cancer, to develop critical biomarkers, and to identify potential candidate tumor suppressors. In addition, induction of systemic or localized DNA damage by chemotherapy or radiation remains a major modality of anti-cancer treatment. The types of relevant DNA damages include DNA double-stranded breaks and interstrand crosslinks, and recombination is a central cellular pathway to repair such damage. Therefore, increased knowledge on the regulation and mechanism of these repair processes will provide fundamental understanding to inform novel strategies of anti-cancer treatment leading to more efficacious treatment. This conference joins investigators studying many diverse aspects of genetic recombination, in a range of biological systems and with different experimental approaches. Presentations will introduce new and unpublished work in the field and will encourage discussion from all participants. Discussions will include the role of the breast cancer susceptibility gene BRCA2 in the control of recombination, the role of recombination in repair of DNA damage caused by cancer treatment relevant drugs and radiation. Characterization of recombination and repair factors known to underlie human syndromes with propensity to cancer, premature aging, immune dysfunction and neurological degeneration will also be discussed, using mammalian and other model genetic systems. By emphasizing truly exceptional research in a conference setting that fosters direct interaction, the FASEB conference provides unique opportunities for the exchange of information, technology and perspective among new and established investigators in the recombination field.

 描述（由申请人提供）：本申请寻求对将于2015年7月19日至24日在科罗拉多的汽船泉举行的美国实验生物学学会联合会（FASEB）遗传修饰和基因组重排会议的部分支持。这将是致力于这些主题的一系列非常成功的两年期会议中的第16次。本次会议的目的是加入研究遗传重组的许多不同方面的研究人员，在一系列生物系统和不同的实验方法。演讲将介绍关于该领域及时问题的新的和未发表的工作，并将包括所有与会者的讨论。FASEB会议为信息和技术的交流提供了独特的机会，这些信息和技术可以在重组领域得到赞赏和利用。会议涵盖了许多对癌症有重要意义的领域。同源重组是防止基因组重排的重要机制，基因组重排可促进致癌状态，并且参与重组机制和调控的许多基因/蛋白质已被鉴定为肿瘤抑制基因。因此，重组机制的研究对于理解癌症的病因学、开发关键的生物标志物和鉴定潜在的候选肿瘤抑制剂至关重要。此外，通过化疗或放疗诱导全身或局部DNA损伤仍然是抗癌治疗的主要方式。相关DNA损伤的类型包括DNA双链断裂和链间交联，重组是修复此类损伤的中心细胞途径。因此，增加对这些修复过程的调节和机制的了解将提供基本的理解，以告知抗癌治疗的新策略，从而获得更有效的治疗。本次会议加入研究人员研究遗传重组的许多不同方面，在一系列生物系统和不同的实验方法。演讲将介绍该领域新的和未发表的工作，并鼓励所有与会者进行讨论。讨论将包括乳腺癌易感基因BRCA 2在控制重组中的作用，重组在修复癌症治疗相关药物和辐射引起的DNA损伤中的作用。重组和修复因子的特征，已知的基础人类综合征与癌症的倾向，过早衰老，免疫功能障碍和神经退行性疾病也将讨论，使用哺乳动物和其他模型遗传系统。通过强调在促进直接互动的会议环境中进行真正卓越的研究，FASEB会议为重组领域的新老研究人员之间交流信息，技术和观点提供了独特的机会。