FASEB SRC on Genetic Recombination and Genome Rearrangements

 描述(申请人提供)：本申请寻求部分支持美国实验生物学学会联合会(FASE B)将于2015年7月19-24日在科罗拉多州斯普林斯举行的关于基因重组和基因组重排的会议。这将是致力于这些主题的一系列非常成功的两年一次的会议中的第16次。这次会议的目的是与研究人员一起研究基因重组的许多不同方面，在一系列生物系统中，并使用不同的实验方法。演讲将介绍关于实地及时问题的新的和未发表的工作，并将包括所有参与者的讨论。FASEB会议为交流信息和技术提供了独特的机会，可以在整个重组领域欣赏和利用这些信息和技术。这次会议涵盖了许多对癌症具有重要意义的领域。同源重组是防止基因组重排的重要机制，可促进肿瘤发生状态，许多参与重组机制和调控的基因/蛋白已被鉴定为肿瘤抑制基因。因此，对重组机制的研究对于了解癌症的病因、开发关键的生物标记物和识别潜在的候选肿瘤抑制因子至关重要。此外，化疗或放疗引起的全身性或局部性DNA损伤仍然是抗癌治疗的主要方式。相关的DNA损伤类型包括DNA双链断裂和链间交联，而重组是修复这种损伤的中心细胞途径。因此，对这些修复过程的调节和机制的更多了解将为指导抗癌治疗的新策略提供基本的理解，从而导致更有效的治疗。这次会议加入了研究人员的行列，他们在一系列生物系统中用不同的实验方法研究基因重组的许多不同方面。演讲将介绍该领域新的和未发表的工作，并将鼓励所有参与者进行讨论。讨论将包括乳腺癌易感基因BRCA2在控制重组中的作用，重组在修复癌症治疗相关药物和辐射造成的DNA损伤中的作用。利用哺乳动物和其他模型遗传系统，还将讨论重组和修复因子的特征，这些因子是人类综合征的基础，具有癌症倾向、过早衰老、免疫功能障碍和神经退化。通过在促进直接互动的会议环境中强调真正特殊的研究，FASEB会议为重组领域新老研究人员之间的信息、技术和观点交流提供了独特的机会。

 DESCRIPTION (provided by applicant): This application seeks partial support for the Federation of American Societies of Experimental Biology (FASEB) conference on Genetic Recombination and Genome Rearrangements to be held July 19-24, 2015 in Steamboat Springs, Colorado. This will be the 16th in a series of highly successful bi-annual conferences devoted to these topics. This conference aims to join investigators studying many diverse aspects of genetic recombination, in a range of biological systems and with different experimental approaches. Presentations will introduce new and unpublished work on timely questions in the field and will include discussion from all participants. The FASEB conference provides unique opportunities for the exchange of information and technology that can be appreciated and exploited across the recombination field. The conference covers many areas of significance for cancer. Homologous recombination is an important mechanism for preventing genome rearrangements that can promote the oncogenic state, and many genes/proteins involved in the mechanisms and regulation of recombination have been identified as tumor suppressor genes. Hence, studies of recombination mechanisms are paramount to understanding the etiology of cancer, to develop critical biomarkers, and to identify potential candidate tumor suppressors. In addition, induction of systemic or localized DNA damage by chemotherapy or radiation remains a major modality of anti-cancer treatment. The types of relevant DNA damages include DNA double-stranded breaks and interstrand crosslinks, and recombination is a central cellular pathway to repair such damage. Therefore, increased knowledge on the regulation and mechanism of these repair processes will provide fundamental understanding to inform novel strategies of anti-cancer treatment leading to more efficacious treatment. This conference joins investigators studying many diverse aspects of genetic recombination, in a range of biological systems and with different experimental approaches. Presentations will introduce new and unpublished work in the field and will encourage discussion from all participants. Discussions will include the role of the breast cancer susceptibility gene BRCA2 in the control of recombination, the role of recombination in repair of DNA damage caused by cancer treatment relevant drugs and radiation. Characterization of recombination and repair factors known to underlie human syndromes with propensity to cancer, premature aging, immune dysfunction and neurological degeneration will also be discussed, using mammalian and other model genetic systems. By emphasizing truly exceptional research in a conference setting that fosters direct interaction, the FASEB conference provides unique opportunities for the exchange of information, technology and perspective among new and established investigators in the recombination field.