Translational Vision Science Research at Oregon Health & Science University

描述(由申请人提供)：这项建议的前提是，培训下一代视觉科学家将基础科学研究转化为临床和公共卫生干预措施，这将是推动该领域发展的关键。基础科学技术进步正在以前所未有的速度发展。然而，我们的观察是，眼科医生往往缺乏背景，无法了解最近的基础和临床研究成果如何应用于他们的实践，而视觉科学家往往缺乏足够的视角来确定临床知识中的差距，以指导他们的研究。此应用程序建议为俄勒冈健康与科学大学(OHSU)基础或应用科学博士前培训项目的学生、经过博士培训的科学家或临床科学家实施T32转换视觉研究培训计划。总体目标是通过在多学科环境中提供教学教育和密集的指导研究经验，为个人在视觉科学研究方面成功的学术和科学职业生涯做好准备。OHSU的视力研究和培训环境是高度协作和跨学科的，在将基因治疗、分子遗传学、药物开发、临床试验、眼科成像和生物医学信息学等领域的研究从工作台转化到床边方面提供强有力的方案支持。该大学拥有临床眼科和基础视觉科学方面的顶级教育项目，并在2011年由蓝岭医学研究所支持的研究中在全国排名第二。这一培训计划将填补IS教育的一个重要空白，因为OHSU是俄勒冈州唯一的学术医疗中心，也是太平洋西北部为数不多的几个主要中心之一，但这里没有支持视觉科学或眼科研究的教学培训的计划。我们希望利用OHSU现有的基础设施，让更多的博士后和博士后学员受益于这种研究和教育环境，并为之做出贡献。具体地说，我们建议为3名博士后和1名博士后学员提供视觉科学T32项目，该项目将与分子生物学、细胞生物学、遗传学、神经科学、免疫学和生物医学信息学等领域的正在进行的研究和OHSU现有的研究生项目相结合。培训将由五个关键部分组成：(1)与导师和合作者一起的研究项目，(2)为期一年的教学课程，涵盖基础、临床和翻译视觉科学的基础，(3)每月一次的期刊俱乐部，讨论当代科学文章和学员正在进行的研究，(4)机构范围的教育和职业发展活动，以及(5)负责任的研究行为培训。我们相信，这一计划将为具有基础科学背景的学员提供临床前景，并为具有临床眼科背景的学员提供基础科学背景。OHSU是一个通过T32计划在基础和临床研究方面进行严格培训的环境，将为新一代年轻研究人员提供优化翻译视觉研究的工具。

DESCRIPTION (provided by applicant): The premise of this proposal is that training the next generation of vision scientists in translation of basic science research to clinical and public health interventions will be critical toward advancing the field. Basic scientific and technologica advances are occurring at an unprecedented pace. However, our observation has been that ophthalmologists often lack the background to understand how recent basic and clinical research findings may be applied to their practices, and visual scientists often lack adequate perspective to identify gaps in clinical knowledge to guide their research. This application proposes to implement a T32 translational vision research training program for students in pre-doctoral training programs in basic or applied science, doctorally- trained scientists, or clinicia-scientists at Oregon Health & Science University (OHSU). The overall goal is to prepare individuals for successful academic and scientific careers in vision science research by providing didactic education and intensive mentored research experience in a multidisciplinary environment. The vision research and training environment at OHSU is highly collaborative and interdisciplinary, with strong programmatic support in translation of research from bench to bedside in areas such as gene therapy, molecular genetics, drug development, clinical trials, ophthalmic imaging, and biomedical informatics. The university has top educational programs in clinical ophthalmology and basic visual science, and was ranked #2 nationally in NEI-supported research by the Blue Ridge Institute for Medical Research in 2011. This training program will fill an important gap is education because OHSU is the only academic medical center in Oregon and one of the few major centers in the Pacific Northwest, yet there are no programs to support didactic training in visual science or ophthalmic research here. We hope to leverage the existing infrastructure at OHSU to allow more pre-doctoral and post-doctoral trainees to benefit from and contribute toward this research and educational environment. Specifically, we propose a vision science T32 program for 3 pre- doctoral and 1 post-doctoral trainee, which will be integrated with ongoing research and existing OHSU graduate programs in fields such as molecular biology, cell biology, genetics, neuroscience, immunology, and biomedical informatics. Training will consist of five key components: (1) research projects with mentors and collaborators, (2) a year-long didactic course covering fundamentals of basic, clinical, and translational vision science, (3) a monthly journal club for discussion of contemporary scientific articles and ongoing research by trainees, (4) institution-wide education and career development activities, and (5) training in responsible conduct of research. We believe that this program will provide clinical perspective to trainees with existing backgrounds in basic science, and basic science background to trainees with existing backgrounds in clinical ophthalmology. OHSU is a setting where rigorous training in basic and clinical research through this T32 program will provide a generation of young researchers with the tools to optimize translational vision research.