Translational Vision Science Research at Oregon Health & Science University

描述（由申请人提供）：该提案的前提是，培训下一代视觉科学家将基础科学研究转化为临床和公共卫生干预措施，这对推进该领域至关重要。基础科学和技术正在以前所未有的速度进步。然而，我们的观察结果是，眼科医生往往缺乏背景知识，无法了解最近的基础和临床研究结果如何应用于他们的实践，视觉科学家往往缺乏足够的视角来识别临床知识的差距，以指导他们的研究。本申请提出为俄勒冈州健康与科学大学（OHSU）的基础或应用科学的博士前培训课程的学生、博士培训的科学家或临床科学家实施T32转化视觉研究培训课程。总体目标是通过在多学科环境中提供教学教育和密集的指导研究经验，为个人在视觉科学研究中成功的学术和科学事业做好准备。OHSU的视觉研究和培训环境是高度协作和跨学科的，在基因治疗，分子遗传学，药物开发，临床试验，眼科成像和生物医学信息学等领域的研究从实验室到床边的翻译方面提供了强大的计划支持。该大学在临床眼科学和基础视觉科学方面拥有顶尖的教育课程，并在2011年蓝岭医学研究所支持的NEI研究中排名全国第二。该培训项目将填补教育方面的一个重要空白，因为OHSU是俄勒冈州唯一的学术医疗中心，也是太平洋西北部少数几个主要中心之一，但这里没有支持视觉科学或眼科研究教学培训的项目。我们希望利用OHSU现有的基础设施，让更多的博士前和博士后学员从这种研究和教育环境中受益并做出贡献。具体来说，我们提出了一个视觉科学T32计划，为3名博士前和1名博士后实习生，这将与正在进行的研究和现有的OHSU研究生课程相结合，如分子生物学，细胞生物学，遗传学，神经科学，免疫学和生物医学信息学。培训将包括五个关键部分：（1）与导师和合作者的研究项目，（2）为期一年的教学课程，涵盖基础，临床和转化视觉科学的基础知识，（3）每月杂志俱乐部，讨论当代科学文章和学员正在进行的研究，（4）机构范围内的教育和职业发展活动，（5）负责任地进行研究的培训。我们相信，该计划将提供临床的观点，以学员与现有的背景，在基础科学，基础科学背景的学员与现有的背景，在临床眼科。OHSU是一个通过T32计划进行基础和临床研究的严格培训的环境，将为一代年轻研究人员提供优化翻译视觉研究的工具。

DESCRIPTION (provided by applicant): The premise of this proposal is that training the next generation of vision scientists in translation of basic science research to clinical and public health interventions will be critical toward advancing the field. Basic scientific and technologica advances are occurring at an unprecedented pace. However, our observation has been that ophthalmologists often lack the background to understand how recent basic and clinical research findings may be applied to their practices, and visual scientists often lack adequate perspective to identify gaps in clinical knowledge to guide their research. This application proposes to implement a T32 translational vision research training program for students in pre-doctoral training programs in basic or applied science, doctorally- trained scientists, or clinicia-scientists at Oregon Health & Science University (OHSU). The overall goal is to prepare individuals for successful academic and scientific careers in vision science research by providing didactic education and intensive mentored research experience in a multidisciplinary environment. The vision research and training environment at OHSU is highly collaborative and interdisciplinary, with strong programmatic support in translation of research from bench to bedside in areas such as gene therapy, molecular genetics, drug development, clinical trials, ophthalmic imaging, and biomedical informatics. The university has top educational programs in clinical ophthalmology and basic visual science, and was ranked #2 nationally in NEI-supported research by the Blue Ridge Institute for Medical Research in 2011. This training program will fill an important gap is education because OHSU is the only academic medical center in Oregon and one of the few major centers in the Pacific Northwest, yet there are no programs to support didactic training in visual science or ophthalmic research here. We hope to leverage the existing infrastructure at OHSU to allow more pre-doctoral and post-doctoral trainees to benefit from and contribute toward this research and educational environment. Specifically, we propose a vision science T32 program for 3 pre- doctoral and 1 post-doctoral trainee, which will be integrated with ongoing research and existing OHSU graduate programs in fields such as molecular biology, cell biology, genetics, neuroscience, immunology, and biomedical informatics. Training will consist of five key components: (1) research projects with mentors and collaborators, (2) a year-long didactic course covering fundamentals of basic, clinical, and translational vision science, (3) a monthly journal club for discussion of contemporary scientific articles and ongoing research by trainees, (4) institution-wide education and career development activities, and (5) training in responsible conduct of research. We believe that this program will provide clinical perspective to trainees with existing backgrounds in basic science, and basic science background to trainees with existing backgrounds in clinical ophthalmology. OHSU is a setting where rigorous training in basic and clinical research through this T32 program will provide a generation of young researchers with the tools to optimize translational vision research.