Translational Vision Science Research at Oregon Health & Science University

俄勒冈健康中心的转化视觉科学研究

• 批准号: 8889686
• 负责人: MICHAEL F. CHIANG
• 金额: $ 19.31万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8889686
• 关键词: Health Sciences; Oregon; Research; Universities; vision science

DESCRIPTION (provided by applicant): The premise of this proposal is that training the next generation of vision scientists in translation of basic science research to clinical and public health interventions will be critical toward advancing the field. Basic scientific and technologica advances are occurring at an unprecedented pace. However, our observation has been that ophthalmologists often lack the background to understand how recent basic and clinical research findings may be applied to their practices, and visual scientists often lack adequate perspective to identify gaps in clinical knowledge to guide their research. This application proposes to implement a T32 translational vision research training program for students in pre-doctoral training programs in basic or applied science, doctorally- trained scientists, or clinicia-scientists at Oregon Health & Science University (OHSU). The overall goal is to prepare individuals for successful academic and scientific careers in vision science research by providing didactic education and intensive mentored research experience in a multidisciplinary environment. The vision research and training environment at OHSU is highly collaborative and interdisciplinary, with strong programmatic support in translation of research from bench to bedside in areas such as gene therapy, molecular genetics, drug development, clinical trials, ophthalmic imaging, and biomedical informatics. The university has top educational programs in clinical ophthalmology and basic visual science, and was ranked #2 nationally in NEI-supported research by the Blue Ridge Institute for Medical Research in 2011. This training program will fill an important gap is education because OHSU is the only academic medical center in Oregon and one of the few major centers in the Pacific Northwest, yet there are no programs to support didactic training in visual science or ophthalmic research here. We hope to leverage the existing infrastructure at OHSU to allow more pre-doctoral and post-doctoral trainees to benefit from and contribute toward this research and educational environment. Specifically, we propose a vision science T32 program for 3 pre- doctoral and 1 post-doctoral trainee, which will be integrated with ongoing research and existing OHSU graduate programs in fields such as molecular biology, cell biology, genetics, neuroscience, immunology, and biomedical informatics. Training will consist of five key components: (1) research projects with mentors and collaborators, (2) a year-long didactic course covering fundamentals of basic, clinical, and translational vision science, (3) a monthly journal club for discussion of contemporary scientific articles and ongoing research by trainees, (4) institution-wide education and career development activities, and (5) training in responsible conduct of research. We believe that this program will provide clinical perspective to trainees with existing backgrounds in basic science, and basic science background to trainees with existing backgrounds in clinical ophthalmology. OHSU is a setting where rigorous training in basic and clinical research through this T32 program will provide a generation of young researchers with the tools to optimize translational vision research.

描述（由申请人提供）：该提案的前提是，培训下一代的愿景科学家将基础科学研究转化为临床和公共卫生干预措施将对推进该领域至关重要。基本的科学和技术进步正在以前所未有的速度发生。但是，我们的观察结果是，眼科医生通常缺乏背景，无法理解最近的基础和临床研究发现如何应用于他们的实践，而视觉科学家通常缺乏足够的观点来识别临床知识的差距来指导他们的研究。该申请建议在俄勒冈州健康与科学大学（OHSU）的基础科学或应用科学科学家或临床科学家或临床科学家（OHSU）的基础科学或诊所科学家（OHSU）中为学生实施T32转化视觉研究培训计划。总体目标是通过在多学科环境中提供教学教育和深入的指导研究经验，使个人在视力科学研究中为成功的学术和科学职业做好准备。 OHSU的视觉研究和培训环境具有高度的协作和跨学科，在基因治疗，分子遗传学，药物开发，临床试验，眼科成像和生物医学信息学等领域的研究中，在从长凳上转换为床边的研究方面有很大的程序支持。 The university has top educational programs in clinical ophthalmology and basic visual science, and was ranked #2 nationally in NEI-supported research by the Blue Ridge Institute for Medical Research in 2011. This training program will fill an important gap is education because OHSU is the only academic medical center in Oregon and one of the few major centers in the Pacific Northwest, yet there are no programs to support didactic training in visual science or ophthalmic research here.我们希望利用OHSU的现有基础设施来允许更多的博士后和博士后学员从中受益并为这项研究和教育环境贡献。具体而言，我们为3个博士和1名博士后学员提供了视觉科学T32计划，该计划将与正在进行的研究和现有的OHSU研究生计划集成到分子生物学，细胞生物学，遗传学，神经科学，免疫学和生物医学信息学等领域。培训将由五个关键组成部分组成：（1）与导师和合作者一起研究项目，（2）为期一年的教学课程，涵盖基本，临床和翻译视觉科学的基础知识，（3）每月的期刊俱乐部，讨论当代科学文章以及受训者正在进行的研究，（4）范围内的教育和职业发展活动，以及（5）负责任的研究培训。我们认为，该计划将为具有基础科学的现有背景以及具有临床眼科现有背景的受训者的基础科学背景的受训者提供临床观点。 OHSU是通过该T32计划进行基础和临床研究的严格培训的环境，将为一代年轻的研究人员提供优化转化视觉研究的工具。