Physics of Cancer Microfabrication

微加工核心将建立以支持癌症物理中心的研究人员，特别是为微加工和软光刻提供资源。核心将主要支持中心的项目2和项目3。例如，粘性微图案化表面将用于研究几何形状对运动性的影响。在另一个例子中，将制造基于微流体的装置以研究微流体对微流体的影响。 空间力、细胞外基质、细胞顺应性和粘附性对肿瘤细胞迁移的影响。这些实验将提供新的见解的过程中的内渗和外渗。核心将位于霍普金斯的霍姆伍德校园600平方米。英尺专门的实验室空间。核心系统将作为一个用户设施进行管理和经营，并有完善的协议，用于：安排、管理和维护设备、培训、监督用户以及计费和费用回收。两名博士后助理将负责日常运作，包括为中心的研究人员制造设备和平台，培训研究人员进行微制造，以及监督设施中的自我用户。

The Microfabrication Core will be established to support the investigators in the Cancer Physics Center, specifically to provide resources for microfabrication and soft-lithography. The Core will mainly support Projects 2 and 3 in the Center. For example, adhesive micropatterned surfaces will be used to study the influence of geometry on motility. In another example, microfluidic-based devices will be fabricated to study the influence of steric forces, extracellular matrix, cell compliance, and adhesiveness on tumor cell migration. These experiments will provide new insight into the process of intravasation and extravasation. The core will be located at the Hopkins' Homewood campus in 600 sq. ft. of dedicated laboratory space. The Core will be managed and administered as a user facility with well established protocols for: scheduling, managing and maintaining equipment, training, providing oversight of users, and billing and cost recovery. Two post-doctoral associates will be responsible for the day-to-day operation, including fabrication of devices and platforms for researchers in the Center, the training of researchers in microfabrication, and the oversight of self-users in the facility.