MUSC Center for Oral Health Research

在第三阶段COBRE的支持下，MUSC口腔健康研究中心（COHR）将完成向长期可持续发展的过渡，成为一个具有全国竞争力的口腔健康多学科研究项目。COHR旨在扩大MUSC在口腔和颅面研究中资助的研究人员的临界质量，并增强作为平台的科学核心资源，以提高我们的教师成功竞争NIH资金的能力。迄今为止，COHR共辅导了28名初级调查员，其中17人获得晋升，3人获得终身职位; 28人中有23人留在我们机构。作为一个团队，他们已经发表了250多篇同行评审的论文和摘要。他们得到了总共50个校外赠款的支持，其中包括24个NIH赠款，他们担任PI或关键人员。这项建议的主要组成部分是：A）行政核心，提供组织、协调、财政和问责职能; B）实验室核心，通过四个互动设施-生物动物研究设施、矿化组织设施、口腔癌研究设施和激光捕获显微切割设施-提供服务; C）临床核心（C-COHR）通过基于社区的参与性研究促进临床和转化研究并刺激研究发现;和D）试点项目和可行性项目计划，为试点研究提供支持，以促进利用中心资源的研究项目，人员和设施，并促进与COHR成员的互动。COHR还有一个由NIH资助的研究培训部分（T-COHR），以补充这一建议。COHR的发展和活动推动了牙科医学院的重大文化转变，并促进了校园和国家层面对口腔健康研究的认可。研究发现和赠款的成功创造了一个互动的，支持性的环境，在口腔医学学院的研究。因此，口腔健康研究中心的战略定位是长期成功的关键资源，为研究人员开发新技术，治疗和干预措施，以提高人们的口腔健康在南卡罗来纳州和美国。

With Phase III COBRE support, the MUSC Center for Oral Health Research (COHR) will complete its transition to long-term sustainability as a nationally competitive multidisciplinary research program in oral health. The COHR was conceived to expand the critical mass of funded investigators at MUSC in oral and craniofacial research and to enhance scientific core resources that serve as platforms to increase the capacity of our faculty to compete successfully for NIH funding. The COHR has mentored a total of 28 junior investigators to date, of which 17 have been promoted and 3 have earned tenure; 23 of the 28 have been retained at our institution. As a group, they have published more than 250 peer-reviewed papers and abstracts. They have received support from a total of 50 extramural grants, including 24 NIH grants on which they serve as PI or Key Personnel. The major components of this proposal are: A) The Administrative Core providing organizational, coordinating, fiscal and accountability functions; B) The Laboratory Core (L-COHR) providing services through four interactive facilities--the Gnotobiotic Animal Research Facility, Mineralized Tissue Facility, Oral Cancer Research Facility, and Laser Capture Microdissection Facility; C) The Clinical Core (C-COHR) fostering clinical and translational research and stimulating research discoveries through community-based participatory research; and D) The Pilot Project and Feasibility Projects Program providing support for pilot studies to foster research projects that utilize Center resources, personnel and facilities and facilitate interaction with COHR members. The COHR also has an NIH-funded research training component (T-COHR) that complements this proposal. The COHR's growth and activities have fueled a major cultural shift in the College of Dental Medicine and fostered recognition for oral health research at both campus and national levels. Research discoveries and grant success have created an interactive, supportive environment for research in the College of Dental Medicine. Thus, the Center for Oral Health Research is strategically positioned for long-term success as a critical resource for investigators developing new technologies, therapeutics and interventions to enhance the oral health of people in South Carolina and the United States.